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| Articles
by
Mehdi Nematbakhsh |
Total Records (
2 ) for
Mehdi Nematbakhsh |
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Mehdi Nematbakhsh
,
Zahra Heydarzadeh
,
Lila Borjian
and
Shaghayegh Haghjooyejavanmard
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Nitric Oxide (NO) donors such as L-arginine are a
candidate to restores endothelial function. NO itself may change
endothelial permeability which is an important factor to control vascular
homeostasis. So, the effect of L-arginine on aorta and coronary arteries
permeability was the objective of this study. 20 male rats were randomly
divided into two groups of oral administrated L-arginine (4 g/l) and
control. After five weeks of experiment, the serum level of nitrite by
Griess reagent method and direct blood pressure were measured. The aorta
and coronary arteries permeability were determined by extravasation of
injected Evan Blue dye. The results indicate that after the 5 weeks of
experiment, L-arginine increases mean arterial pressure (group I: 157±6,
group II: 108.2±10.1 mmHg; p<0.05) and the serum level of nitrite(group
I: 35.69±6.88, group II: 23.21±2.72 µmol/l; p<0.05) significantly. No
statistical differences were observed in endothelial permeability of aorta
(group I: 66.6±5.4, group II: 85.23±10.64 µg/g.tissue) and coronary
arteries (group I: 28.2±3.17, group II: 22.83±1.39 µg/g. tissue) between
the groups. Low dose L-arginine may increases the level of nitrite; last
metabolite of NO in plasma, but its effect on aorta and coronary arteries
permeability is not certain. |
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Shaghayegh Haghjooyjavanmard
,
Mehdi Nematbakhsh
and
Masoud Soleimani
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Vascular Endothelial Growth Factor (VEGF) and Nitric Oxide (NO) play an important role for maintaining endothelial integrity. The purpose is to investigate the VEGF alteration during early atherosclerosis lesion formation in an animal model of hypercholesterolemia. We also measured nitrite to observe the relationship between VEGF and endothelial NO production. 20 white male rabbits randomly assigned in 2 groups (1% high-cholesterol diet, HC group, n = 14, or standard diet, control, n = 6) for 4 weeks. The serum levels of VEGF and nitrite (NO metabolite) were determined. Fatty streaks were measured in rabbit’s aortas. The results indicated that the serum level of VEGF concentration was significantly higher in hypercholesterolemic rabbits and negatively correlated with fatty streak lesions (r = -0.89, p<0.05). The serum level of nitrite was significantly higher in HC group than the control (p<0.05). There was a significant negative correlation between serum level of nitrite and VEGF (r = -0.55, p<0.05). It is concluded that, the increased VEGF in early atherosclerosis may be regarded as a safeguarding response to endothelial injury, which is responsible for maintaining endothelial integrity. |
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