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Articles by Mehdi Shafiee Ardestani
Total Records ( 1 ) for Mehdi Shafiee Ardestani
  Soheila Hekmat , Mehdi Shafiee Ardestani , Seyed E.S. Ebrahimi , Maryam Ravan and Mitra Elmi
  Reports suggest the increase in the incidence risk of the coronary heart diseases in diabetic patients. This experiment is carried out to study the differences between inhibitory effects of selective type5 cGMP phophodiestrase inhibitor Tadalafil±dipyridamol on the isolated prepared of ileum of the control and diabetic rats. The diabetic rats were created and kept for 6-8 weeks. A piece of ileum was separated and set up in an organ bath containing physiological salt solution. Contractions were induced by KCl (80 mM) and Tadalafil was added in non-cumulative manner to relax the ileum. Tadalafil induced relaxation of the precontracted isolated ileum preparation in both diabetic and control rats. Relaxation responses in normal and diabetic rats were found similar and there was not any significant differences between EC50 (concentration that results in half-maximal response) of Tadalafil in both control and diabetic rats. Addition of dipyridamol increased the responses to Tadalafil. The present study showed the effectiveness for selective phophodiestrase type5 inhibition to produce equivalent relaxant effect on isolated preparation of ileum obtained from either control or diabetic rats.
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