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Articles by Megumi Fujiwara
Total Records ( 3 ) for Megumi Fujiwara
  Megumi Fujiwara , Toko Sato , Hiroyuki Tazaki , Ichiro Yamamoto , Koh Kawasumi and Toshiro Arai
  Hyperlipidemia refers to increase of triglyceride (TG) and/or total cholesterol (T-cho) in blood. Fatty Acids (FAs) have important roles in the lipid metabolism. The aim of this study was to determine the FA composition of plasma lipid fractions in dogs with hyperlipidemia and to evaluate the FA composition as a new diagnostic marker for obesity at early stage. Thirty-nine dogs were classified into healthy or hyperlipidemia based on the criteria to diagnose hyperlipidemia. The blood biochemical values, such as TG, T-cho, glucose, insulin, adiponectin and Non-Esterified Fatty Acid (NEFA) were measured. FA composition profile was performed on GC/MS system. The values of plasma TG, insulin and NEFA of the hyperlipidemia group were significantly higher than that of control group. Hyperlipidemia group tended to show lower concentration of adiponectin. It was found that only the levels of TG and NEFA, but not T-cho increased significantly in early stage of hyperlipidemia. In hyperlipidemia group, percentages of myristic acid (C14:0), parmitoleic acid (C16:1) and oleic acid (C18:1) increased in total FAs. And the percentage of C18:1 increased in NEFA. Indeed, the higher level of insulin and lower adiponectin concentration were seen in hyperlipidemia group. These results suggest that appearance of insulin resistance may be the result of increases of certain FAs in early stage of insulin resistance.
  Nobuko Mori , Gebin Li , Megumi Fujiwara , Shingo Ishikawa , Koh Kawasumi , Ichiro Yamamoto and Toshiro Arai
  The prevalence of obese cats has increased because of over calorie diet and physical inactivity. Obesity has been found to be associated with oxidative stress and Reactive Oxygen Species (ROS). Unfortunately oxidative stress status at the early phase of obesity in high fat fed cats is not well understood. The objectives of this study were (1) To evaluate lipid and glucose metabolism using enzymatic, hormonal and oxidative stress biomarkers at the early obese phase of cats fed on a high-fat diet and (2) To identify rapidly changing variables to use as a diagnostic marker for lipid metabolic disorders in cats. Total 13 domestic female cats were divided into two groups which were fed on control and high-fat diet for eight weeks, respectively. After the feeding period, they were compared in metabolic variables and oxidative stress markers in plasma and tissues. As results, High-fat diet including much long chain fatty acids promoted rapid changes in lipid metabolism, particularly accelerated β-oxidation of fatty acids and oxidative stress in the liver of the cats. G6PD, GPx and SOD were increased in the liver. Insulin resistance was not apparent at the early phase of obesity in cats. Plasma activities of SOD also increased at the early phase of obesity in cats. Remarkable alternation for oxidative stress in liver was observed at the early phase of obesity in cats fed on high fat diet and SOD may be a potential marker of the early phase of obesity in cats.
  Koh Kawasumi , Tomoko Suzuki , Megumi Fujiwara , Nobuko Mori , Ichiro Yamamoto and Toshiro Arai
  Researchers attempted to establish temporary criteria for Metabolic Syndrome (MS) diagnosis in dogs. To verify the usefulness of the selected criteria, researchers measured plasma Glucose (GLU), Triglyceride (TG), Total Cholesterol (TC), Non-Esterified Fatty Acid (NEFA), Alanine Aminotransferase (ALT) and insulin levels as diagnostic markers in 105 clinically healthy dogs. Dog with obesity as an essential factor (BCS = 3.5) in addition to any two of the following three factors 1-3 namely increased plasma GLU levels (≥120 mg dL-1), hyperlipidemic condition, diagnosed with any two of the following three factors, elevated TG (≥165 mg dL-1), TC (≥200 mg dL-1), NEFA (≥1.5 m Eq-1) levels and higher ALT activit (≥100 IU L-1) were diagnosed as MS. Presence of additional factors such as raised insulin levels (≥2.5 ng mL-1), confirmed the MS diagnosis. Based on these criteria, 13 (12.9%) of 101 dogs were diagnosed as MS. In these dogs, NEFA, TC and ALT levels were significantly higher than those in the control dogs (n = 88) without MS. MS was not detected in dogs with Body Condition Score (BCS)<3.
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