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Articles by Meenu Mehta
Total Records ( 3 ) for Meenu Mehta
  Meenu Mehta , Saurabh Satija , Arun Nanda and Munish Garg
  Boswellic Acids (BAs) are the main ingredients of Boswellia serrata (Family: Burseraceae) gum resin extract for the treatment of a variety of inflammatory diseases besides acting as both internal and external stimulant, expectorant, diuretic and stomachic. Despite its multipurpose benefits, BAs have low oral bioavailability especially 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA), (the most therapeutically potential BAs) because these BAs are lipophilic in nature and not solubilises into the intestinal fluid thus limiting its systemic availability. For decades, many attempts have been made to compensate for these disadvantages, with the development of improved delivery platforms as the feasible approaches. The past ten years has witnessed the encouraging progress in the use of nano scale drug delivery systems on BAs such as loading BAs into liposomes, solid lipid nanoparticles as well as the latest reported technologies such as niosomes, phytosomes and nanomicelles etc. This review summarizes the recent works on the design and development of nanoscale delivery systems of BAs, with the goal of harnessing the true difficulties of this multifunctional agent in the clinical arena.
  Pardeep Kumar , Meenu Mehta , Saurabh Satija and Munish Garg
  Controlling post-prandial hyperglycaemia through enzymatic inhibition of starch degradation is an effective therapeutic approach in the management of diabetes mellitus. To achieve this, twelve indigenous antidiabetic Indian medicinal plants such as Trigonella foenum-graecum, Ocimum sanctum, Aegle marmelos, Plantago ovata, Catharanthus roseus, Alium cepa, Azadirachta indica, Aloe vera, Magnifera indica, Terminalia chebula, Eugenia jambolana and Linum usitatisumum were subjected to sequential solvent extraction and thereafter, 48 fractions were screened for their α-amylase inhibitory potential at three dosage levels in vitro. Out of the 144 samples, Eugenia jambolana water extract showed maximum α-amylase inhibitory activity with IC50 value 1.33 mg mL-1 in comparison with standard drug acarbose (IC50 value 0.86 mg mL-1). Quantitative phytochemical analysis of the lead extract revealed the presence of phenolic content as 69.68 mg tannic acid equivalent g-1 while flavonoidal content as 57.39 mg rutin equivalent g-1. Present study indicated Eugenia jambolana as a potential α-amylase inhibitor in the management of diabetes.
  Meenu Mehta and Munish Garg
  Dermal delivery of drugs through proniosome gel is a recent candidate receiving considerable attention. Boswellic Acids (BAs) are pentacyclic triterpenoids; the major constituents of the gum resin derived from the plant Boswellia serrata (family Burseraceae). The BAs have low oral bioavailability due to its lipophilic nature and high first pass metabolism. Proniosomes offer an acceptable vesicle delivery concept with the potential for transdermal drug delivery. This review covers various aspects of proniosomes including mechanism, methods of preparation emphasizing on scope and potential of proniosomal gel as a potential delivery system for boswellic acids.
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