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Articles by Md. Harun-Or-Rashid
Total Records ( 2 ) for Md. Harun-Or-Rashid
  Md. Harun-Or-Rashid , Nurul Karim , M.A. Gafur , Md. Golam Sadik , A.S.M. Anisuzzaman , Noaki Sugimoto and A.T.M. Zafrul Azam
  Extensive chromatographic separation and purification of the organic solvent extracts of stem of I. turpethum afforded three compounds, N-p-coumaryl tyramine (EH4), daucosterol (CH1) and 2-hydroxybenzoic acid (CH2); first isolated from this plant. The structures of these compounds were determined by spectroscopic analysis, including 1H- and 13C-NMR, as well as by UV, IR and electrospray ionization mass spectrometry (ESI-MS). On screening against pathogenic bacteria and fungi; compounds CH2 and EH4 as well as extracts showed significant antibacterial and antifungal activity. The Minimum Inhibitory Concentration (MIC) against Bacillus subtilis and Shigella dysenteriae of compounds CH2 and EH4 were 64 μg mL-1. On in vivo cytotoxicity studies against brine shrimp; compounds CH2 and EH4 showed LC50 (Leathal concentration for 50% mortality) values 54.03 and 43.41 μg mL-1, respectively.
  Md. Harun-or-Rashid , M.A. Gafur , Md. Golam Sadik and Md. Aziz Abdur Rahman
  Three compounds H-1 (β-sitosteryl-β-D glucoside), H-2 (22, 23-dihydro-α-spinosteryl glucoside) & CH-2 (salicylic acid) isolated from the chloroform extract of stem of Ipomoea turpethum and the crude petroleum ether, chloroform and ethyl acetate extracts were screened against thirteen pathogenic bacteria for their antibacterial activities. The minimum inhibitory concentration (MIC) of the isolated compound CH-2 was also measured against Bacillus subtilis, Shigella dysenteriae, Sarcina lutea and Escherichia coli. The values were found to be between 128 and 256 µg/ml. The cytotoxic activity of CH-2 and chloroform and ethyl acetate extracts was also measured by brine shrimp lethality bioassay and the LC50 values were found to be 56.23, 199.53 and 31.62 µg/ml, respectively.
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