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Articles by Md. Golam Sadik
Total Records ( 2 ) for Md. Golam Sadik
  Md. Golam Sadik , M. A. Gafur , M. Shah Alam Bhuiyan , M. Motiur Rahman and Helal U. Biswas
  The ethanol extract of Pergularia daemia and its steroidal fraction are reported to have antifertility activity. In this work we studied the alkaloidal fraction of the ethanol extract to observe its antifertility activity. Oral administration of the alkaloidal fraction at a dose of 200mg kg‾1 body weight showed a significant activity in preimplantation stage of female mice. The activity of the alkaloidal fraction, when compared with the steroidal fraction, was found to be more pronounced since the former inhibited not only the fertility of the female mice but also took short period to return the oestrous cycle to normal, with in 4 to 6 days of drug treatment while steroidal fraction treated mice returned to normal within 6 to 8 days.
  Md. Harun-or-Rashid , M.A. Gafur , Md. Golam Sadik and Md. Aziz Abdur Rahman
  Three compounds H-1 (β-sitosteryl-β-D glucoside), H-2 (22, 23-dihydro-α-spinosteryl glucoside) & CH-2 (salicylic acid) isolated from the chloroform extract of stem of Ipomoea turpethum and the crude petroleum ether, chloroform and ethyl acetate extracts were screened against thirteen pathogenic bacteria for their antibacterial activities. The minimum inhibitory concentration (MIC) of the isolated compound CH-2 was also measured against Bacillus subtilis, Shigella dysenteriae, Sarcina lutea and Escherichia coli. The values were found to be between 128 and 256 µg/ml. The cytotoxic activity of CH-2 and chloroform and ethyl acetate extracts was also measured by brine shrimp lethality bioassay and the LC50 values were found to be 56.23, 199.53 and 31.62 µg/ml, respectively.
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