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Articles by Md. Golam Sadik
Total Records ( 3 ) for Md. Golam Sadik
  Kawsar Uddin , Abu Sayeed , Anwarul Islam , Aziz Abdur Rahman , Abbas Ali , G.R.M. Astaq Mohal Khan and Md. Golam Sadik
  Phytochemical examination of the ethyl acetate extract of root parts of Oroxylum indicum Vent. has led to the isolation of two flavonoid: 2,5-dihydroxy-6,7-dimethoxy flavone and 3,7,3’,5’-tetramethoxy-4-hydroxy flavone by a combination of column and preparative thin layer Chromatography. The structure of these compounds were determined by spectroscopic analysis as well as by comparison of their spectral data with previously reported values. The cytotoxicity of these two compounds and crude petroleum ether, ethyl acetate and methanol extracts was done by brine shrimp lethality bioassay. The LC50 values of compound 1 and 2 and petroleum ether, ethyl acetate and methanol extracts were found to be 14.12, 3.80, 3.97, 6.02 and 8.70 μg/ml, respectively.
  Kawsar Uddin , Abu Sayeed , Anwarul Islam , Aziz Abdur Rahman , Seatara Khatun , G.R.M. Astaq Mohal Khan and Md. Golam Sadik
  The chromatographic examination of the ethyl acetate extract of a local plant Oroxylum indicum Vent. (Family: Bignoniaceae) has led to the isolation of two flavonoids: 2,5-dihydroxy-6,7-dimethoxy flavone (Compound 1) and 3, 7, 3`, 5`-tetramethoxy-4`-hydroxy flavone (Compound 2). The in vitro anti microbial activity of crude petroleum ether, ethyl acetate and methanol extracts and compound 1 and 2 was screened against fourteen (five Gram-positive and nine Gram-negative) pathogenic bacteria and seven pathogenic fungi using the disk diffusion method. The zones of inhibition produced by the crude petroleum ether, ethyl acetate and methanol extracts and compound 1 and 2 against pathogenic bacteria were found between 8-16, 8-19, 0-8, 9-18 and 9-21 mm, respectively and against pathogenic fungi, 8-20, 8-18, 9-15, 9-20 and 7-18 mm, respectively. The crude petroleum ether and ethyl acetate extracts and compound 1 and 2 showed mild to moderate activity against all bacteria and fungi, whereas the methanol extract showed little activity against bacteria but moderate activity against fungi. The minimum inhibitory concentration (MIC) of the compound 1 and 2 were measured against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Shigella dysenteriae and the values were found to be between 64-128 μg/ml.
  Md. Harun-Or-Rashid , Nurul Karim , M.A. Gafur , Md. Golam Sadik , A.S.M. Anisuzzaman , Noaki Sugimoto and A.T.M. Zafrul Azam
  Extensive chromatographic separation and purification of the organic solvent extracts of stem of I. turpethum afforded three compounds, N-p-coumaryl tyramine (EH4), daucosterol (CH1) and 2-hydroxybenzoic acid (CH2); first isolated from this plant. The structures of these compounds were determined by spectroscopic analysis, including 1H- and 13C-NMR, as well as by UV, IR and electrospray ionization mass spectrometry (ESI-MS). On screening against pathogenic bacteria and fungi; compounds CH2 and EH4 as well as extracts showed significant antibacterial and antifungal activity. The Minimum Inhibitory Concentration (MIC) against Bacillus subtilis and Shigella dysenteriae of compounds CH2 and EH4 were 64 μg mL-1. On in vivo cytotoxicity studies against brine shrimp; compounds CH2 and EH4 showed LC50 (Leathal concentration for 50% mortality) values 54.03 and 43.41 μg mL-1, respectively.
 
 
 
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