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| Articles
by
Md. Ekramul Islam |
Total Records (
2 ) for
Md. Ekramul Islam |
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Naznin Ara Khatune
,
Md. Ekramul Islam
,
Md. Aziz Abdur Rahman
,
Md. Asik Mosaddik
and
Md. Ekramul Haque
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The potential cytotoxic effect of a new benzofuran derivative, 4-hydroxy hexahydrobenzofuran-7-one
isolated from Nyctanthes arbor-tristis Linn was evaluated on Ehrlich
Ascite Carcinoma (EAC) cells in Swiss Albino mice. 4-Hydroxy hexahydrobenzofuran-7-one
was administered in a daily dose of Bangladesh 20 mg kg-1 of mouse after inoculation
of Ehrlich Ascite Carcinoma (EAC) cell to the mice. After 5 days, the growth
inhibition of cell in percentage was determined in comparison with control mice
and it was found that there was no significant difference between average no.
of cells counted after treatment in mice receiving 4-hydroxy hexahydrobenzofuran-7-
one and in control mice (2.15±0.031) x 107 vs (3.79±0.019) x107
cells, respectively. The compound inhibited the cell growth by 43.27% only.
4-Hydroxy hexahydrobenzofuran-7-one (20mg kg-1 mouse day-1) over 5 days had
no significant cytotoxic effect in mice in dose of 20-mg kg-1 mouse for 5 days. |
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Md. Aziz Abdur Rahman
,
M.A. Gafur
,
Md. Ekramul Islam
,
Md. Anwar-ul-Islam
and
Md. Aktar Uzzaman Chowdhury
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The subacute toxicity study of a brown antimicrobial metabolite Di (2-ethyl hexyl) Phthalate (AK2), isolated from the culture filtrate of a Streptomyces species, was carried out on long Evan`s rats. The studies include the gross general observations such as changes in body weight, haematological profiles [such as total count of red blood cells (RBC) and white blood cells (WBC), differential count of WBC, platelet count and haemoglobin (Hb) percentage], biochemical parameters of blood such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase, uric acid and creatinine and histopathology of the liver, kidney, heart, lung and spleen of both control and experimental groups of rats. The change of haematological and biochemical parameters were statistically insignificant. No abnormalities were found in the histopathology of the liver, kidney, heart, lung and spleen in the experimental group of rats at a dose of 200 μg/rat/day for 14 consecutive days, when compared with the control group. |
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