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Articles by Md. Ekramul Haque
Total Records ( 5 ) for Md. Ekramul Haque
  Md. Ekramul Islam , Naznin Ara Khatune and Md. Ekramul Haque
  The research work was conducted to investigate the in vitro anti-bacterial activity of a glycoside, phenyl ethyl β-D-glucopyranoside, isolated from the stem of the plant Sida rhombifolia. The petroleum ether (C2H5-O-C2H5), chloroform (CHCl3) and ethylacetate (CH3-CO-O-C2H5) extracts of the plant were screened against eleven pathogenic bacteria for their antimicrobial activities. The test materials were found to be significant in vitro antibacterial activities, against most of the test bacteria. The zones of inhibition produced by the test materials were found to be between 8 and 24 mm. The minimum inhibitory concentration (MIC) values of the isolated compound was also determined against Bacillus subtilis, Sarcinia lutea, Escherichia coli and Shigella shiga which were 128, 64, 64 and 128 µg ml-1, respectively.
  Naznin Ara Khatune , Md. Ekramul Islam , Md. Aziz Abdur Rahman , Md. Asik Mosaddik and Md. Ekramul Haque
  The potential cytotoxic effect of a new benzofuran derivative, 4-hydroxy hexahydrobenzofuran-7-one isolated from Nyctanthes arbor-tristis Linn was evaluated on Ehrlich Ascite Carcinoma (EAC) cells in Swiss Albino mice. 4-Hydroxy hexahydrobenzofuran-7-one was administered in a daily dose of Bangladesh 20 mg kg-1 of mouse after inoculation of Ehrlich Ascite Carcinoma (EAC) cell to the mice. After 5 days, the growth inhibition of cell in percentage was determined in comparison with control mice and it was found that there was no significant difference between average no. of cells counted after treatment in mice receiving 4-hydroxy hexahydrobenzofuran-7- one and in control mice (2.15±0.031) x 107 vs (3.79±0.019) x107 cells, respectively. The compound inhibited the cell growth by 43.27% only. 4-Hydroxy hexahydrobenzofuran-7-one (20mg kg-1 mouse day-1) over 5 days had no significant cytotoxic effect in mice in dose of 20-mg kg-1 mouse for 5 days.
  Naznin Ara Khatune , Md. Ekramul Haque and Md. Ashiik Mosaddik
  The chloroform extract and its isolated pure compound NCS-2 from the flowers of Nyctanthes arbor-tristis L. were evaluated for larvicidal activity against common filaria vector, Culex quinquefasciatus Say at different instar under laboratory conditions. The LC50 values for the chloroform extract were 25.67, 22.19; 38.60, 28.95; 53.14, 42.14 and 72.60, 61.82 ppm and for the isolated compound NCS-2 were 73.31, 65.48; 83.02, 67.02; 97.26, 81.84 and 114.68, 99.02 ppm for 1st, 2nd, 3rd and 4th instar larvae respectively at 24 and 48 hours post exposure. The results also showed that the late instar larvae were more resistant to the extract than those of early instars.
  Farjana Nikkon , Zahangir Alam Saud , M. Habibur Rahman and Md. Ekramul Haque
  The research work was conducted to investigate the in vitro antimicrobial activity of the compound Aglycon of Deoxy-Niazimicine (N-benzyl,S-ethyl thioformate) isolated from Moringa oleifera Lam. in comparison with crude chloroform extract. Antibacterial and antifungal activities of the compound-1 and crude extract were observed against fourteen pathogenic bacteria and six pathogenic fungi. Compound-1 isolated from the chloroform (CHCl3) fraction of ethanol extract showed comparatively more in vitro antibacterial activity against Shigella boydii, Shigella dysenteriae and Staphylococcus aureus than the crude chloroform (CHCl3) extract and produced zone of inhibition in between 09 and 13 mm. The MIC values of the compound-1 and crude extract were also determined against B. megaterium, St. aureus, Sh. dysenteriae and Sh. boydii. The values were found to be between 32 to 128 μg ml-1. The compound-1 also showed moderate antifungal activity against Candida albicans and Aspergillus flavus than the crude chloroform extract although the crude extract showed moderate activity against Trichoderma species. Thus compound-1 has antibacterial and antifungal activity and suggested its therapeutic use as an antimicrobial agent.
  Md. Ekramul Islam , Naznin Ara Khatune , M. I. I. Wahed , Md. Ekramul Haque and Md. Ashiik Mosaddik
  The isolated pure compound phenyl ethyl β-D glucopyranoside from the stem of the plant Sida rhombifolia was evaluated for larvicidal activity against common filaria vector, Culex quinquefasciatus at different instar under laboratory conditions. The LC values for the isolated compound was 36.22, 43.94 and 50 44.92, 58.34 and 60.40, 63.32 and 70.72, 82.52 ppm for 1st, 2nd, 3rd and 4th instar larvae Culex quinquefasciatus at 24 and 48 h post exposure, respectively.
 
 
 
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