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Articles by Md. Belal Hossain
Total Records ( 2 ) for Md. Belal Hossain
  Md. Belal Hossain , Mamunur Rashid and A.K.M. Motahar Hossain
  The aim of the present study was to investigate the release of ibuprofen (IB) from matrix tablets using a combination of water insoluble waxy materials with hydrophilic polymers. The waxy materials were added as additives to the hydrophilic polymer, hydroxy propyl methyl cellulose (HPMC). Bees wax (BW), cetyl alcohol (CA) and stearic acid (SA) used as waxy materials that were added in increasing amount (up to 30% of total weight of tablet) to the HPMC based sustained release (SR) matrix tablets. The results showed that the matrix tablets using all the additives released the drug by zero order mechanism. Addition of waxy materials into the matrix significantly decreased the rate of drug release due to the reduction in penetration of the dissolution fluid. From the release profiles excellent correlation was found between the concentration of waxy materials and ibuprofen release rate.
  Md. Belal Hossain , Mamunur Rashid and A.K.M. Motahar Hossain
  The effects of various percentages (0, 3, 6, 9, 12 and 15%) of Glycerol Mono Stearate (GMS), Stearic Acid (SA) and Cetyl Alcohol (CA) on the release rate of Ibuprofen (IB) from polyethylene glycol-4000 (PEG)-based suppositories were studied. Ibuprofen suppositories of PEG-4000 base were prepared using GMS, SA and CA separately in different formulations by fusion method. Dissolution studies showed a rapid release of the drug during 30-60 min from the PEG-based suppositories of IB and almost 75% of the drug was released within this period. But the incorporation of waxy additives GMS, CA and SA in the formulation reduces this rapid release rate of the drug. Three percent GMS containing PEG-based suppositories liberated about 70.0% of the drug within 6 h whereas maximum 45.0% and 51.0% of drug were liberated from 3% SA and 3% CA containing PEG-based suppositories, respectively, within the same time. The drug release reducing capabilities of the waxy additives were found to be in the following order SA>CA>GMS. Utilizing this capability of the additives, sustained release suppositories of ibuprofen could be formulated.
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