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Articles by Md. Aziz Abdur Rahman
Total Records ( 3 ) for Md. Aziz Abdur Rahman
  M. Zakir Sultan , Naznin Ara Khatune , Zakia Sultana Sathi , Md. Shah Alam Bhuiyan , M. Golam Sadik , M. Akteruzzaman Choudury , M. A. Gafur and Md. Aziz Abdur Rahman
  The ethyl acetate extract of yeast extract-glucose broth medium of an Actinomycetes strain, Streptomyces yielded a reddish yellow antibiotic metabolite by chromatographic technique and was identified as 2 N-butanamide 3-methyl 4-methoxy 5-β-L-arabinosyl propanophenone (MZ-4) on the basis of spectral data. The compound exhibited significant antibacterial activity against five gram positive and nine gram negative bacteria when compared with standard Kanamycin antibiotic. The zone of inhibition were observed between 17 to 20 mm. The minimum inhibitory concentration (MIC) of the compound was determined against four gram positive and gram negative bacteria and the values were found between 32 and 64 μg ml-1.
  Md. Harun-ur-Rashid , M.A. Gafur , Md. Golam Sadik and Md. Aziz Abdur Rahman
  The acrylamide derivative, 3-(4-hydroxy-phenyl)-N-[2-(4-hydroxy phenyl)-ethyl]-acrylamide (H-1) was screened against thirteen pathogenic bacteria for its antibacterial activities. The zones of inhibition produced by the test materials were found between 11 and 20 mm. The minimum inhibitory concentration (MIC) was also measured against Bacillus subtilis and Shigella dysenteriae and the value was found to be 128 μg/ml. The cytotoxic activity was also measured by brine shrimp lethality bioassay and the LC50 values of H-1 and standard ampicillin trihydrate were found to be 56.23 and 6.13 μg/ml.
  Md. Aziz Abdur Rahman , M.A. Gafur , Md. Ekramul Islam , Md. Anwar-ul-Islam and Md. Aktar Uzzaman Chowdhury
  The subacute toxicity study of a brown antimicrobial metabolite Di (2-ethyl hexyl) Phthalate (AK2), isolated from the culture filtrate of a Streptomyces species, was carried out on long Evan`s rats. The studies include the gross general observations such as changes in body weight, haematological profiles [such as total count of red blood cells (RBC) and white blood cells (WBC), differential count of WBC, platelet count and haemoglobin (Hb) percentage], biochemical parameters of blood such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), serum alkaline phosphatase, uric acid and creatinine and histopathology of the liver, kidney, heart, lung and spleen of both control and experimental groups of rats. The change of haematological and biochemical parameters were statistically insignificant. No abnormalities were found in the histopathology of the liver, kidney, heart, lung and spleen in the experimental group of rats at a dose of 200 μg/rat/day for 14 consecutive days, when compared with the control group.
 
 
 
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