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Articles by Md. Ashraful Alam
Total Records ( 2 ) for Md. Ashraful Alam
  S.M. Raquibul Hasan , Mariam Jamila , Muntasir Mamun Majumder , Raushanara Akter , Md. Mokarram Hossain , Md. Ehsanul Hoque Mazumder , Md. Ashraful Alam , Rumana Jahangir , Md. Sohel Rana , Md. Arif and Shafiqur Rahman
  Problem statement: Mikania scandens (L.) Willd., a medicinal plant, is popularly used as herbal remedy for various ailments in Bangladesh. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was designed to evaluate analgesic and antioxidant potential of the hydromethanol extract of the leaves of the plant. Approach: The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate and tail immersion method and acetic acid-induced writhing test in mice respectively. The hydromethanol extract was also investigated for its antioxidant action using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, Nitric Oxide (NO) scavenging and reducing power assays. Results: The extract, at the dose of 250 and 500 mg kg-1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods in a dose dependent manner. In acetic acid-induced writhing test, the extract (500 mg kg-1) produced a maximum of 53.73% inhibition (p<0.001) of writhing reaction compared to the reference drug Diclofenac-Na (76%). A dose dependent scavenging of DPPH radical and NO was observed with good reducing power with the extract. In DPPH radical scavenging assay, the IC50 value of the extract was 375.40 μg mL-1 while the IC50 value for the reference ascorbic acid was 55.89 μg mL-1. The IC50 values of the extract and ascorbic acid were 220.43 and 125.10 μg mL-1, respectively in NO scavenging assay. Conclusion: The findings of the study suggested that the extract from Mikania scandens has strong analgesic and antioxidant effects.
  Akhtaruzzaman Chowdhury , Md. Ashraful Alam , Ridwan Bin Rashid , Muhammad Abdullah Al-Mansur , Mohammad S. Rahman and Mohammad A. Rashid
  Corypha taliera Roxb. is a critically endangered palm species. The tree grown in the campus of the University of Dhaka, Bangladesh used to be considered as the only living species in the world. This palm tree raised some interests due to several bioactivities observed earlier and later systematic scientific studies have been undertaken to explore for its secondary metabolites. In the present study, a thorough phytochemical investigation was conducted to explore its chemical features. Initially, the unripe fruits of this palm was extracted with methanol. Later on, it was fractioned by the modified Kupchan partitioning method in to n-hexane, carbontetrachloride, chloroform and aqueous soluble fractions. The n-hexane soluble fraction was subjected to Column Chromatography (CC) over Sephadex LH-20 and the column was eluted with n-hexane-dichloromethane-methanol (2:5:1) mixtures. From the collected fractions stigmasterol (1), β-sitosterol (2), β-amyrin (3), lupeol (4) and betulinic acid (5) were isolated by Preparative Thin Layer Chromatography (PTLC). The structures of these purified compounds were established by extensive spectroscopic analysis and by comparison of their spectral data with published values as well as co-TLC with authentic samples. This is the first report of isolation of steroids and terpenoids from this plant.
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