Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by Md. Ashik Mosaddik
Total Records ( 1 ) for Md. Ashik Mosaddik
  Laizuman Nahar , Fatema Nasrin , Ronok Zahan and Md. Ashik Mosaddik
  Anti-nociceptive and anti-inflammatory effects of methanolic extract of Wrightia arborea (MEWA) were examined using different models in rats. MEWA was given to rats orally upto 2000 mg kg-1 b.wt. for acute toxicity study and observed for 14 days. Anti-nociceptive activity was evaluated in rats against Acetic acid induced writhing (chemically induced pain) and Tail immersion method (thermally induced pain). Acute anti-inflammatory activity of MEWA was also evaluated in Formaline-induced rat paw edema model and Carrageenan-induced hind paw edema model in rats. Results demonstrated that no mortality was found upto single dose of 2000 mg kg-1 b.wt. in rats even after 14 days observation. In comparison to control group MEWA at 100 and 200 mg kg-1 b.wt. showed highly significant anti-nociceptive activity against chemically (p<0.001) as well as thermally (p<0.05 and p<0.001) induced pain as compared to standard drugs, indomethacin and nalbufin, respectively. In the formalin test, both the doses of 100 and 200 mg kg-1 of extract significantly prevented increase in volume of paw edema (p<0.05 and p<0.01) both in the neurogenic and inflammatory phases. MEWA (200 and 400 mg kg-1 p.o.) also significantly prevented increase in volume of paw edema in Carrageenan test (p<0.05 and p<0.001). The results suggest that MEWA has significant analgesic and anti-inflammatory potential which may be mediated by central and peripheral mechanism.
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility