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Articles by Mbatchou Adolphe
Total Records ( 1 ) for Mbatchou Adolphe
  Ngueguim Tsofack Florence , Mbatchou Adolphe , Donfack Jean Hubert , Dzeufiet Djomeni Desire Paul , Gounoue Kamkumo Raceline , Djouwoug Noussi Clarice , Kamtchouing Pierre and DimoTheophile
  Background and Objective: Dichrocephala integrifolia is used in traditional medicine for the treatment of many diseases including hepatic disorders. The present study was undertaken to evaluate the preventive effects of the aqueous extract of D. integrifolia leaves on ethanol induced-hepatoxicity. Methodology: In preventive treatment, animals received aqueous extract of D. integrifolia at different doses (100 or 200 mg kg–1) or simepar (200 mg kg–1) for one week. A unique dose of 40° ethanol (4 g kg–1) was daily administered orally to animals during 2 weeks. At the end of treatment, transaminases aspartate amino-transferase (AST), alanin amino-transferase (ALT), bilirubin, alkaline phosphatase (ALP), lipid profile, serum and hepatic proteins, superoxide dismutase, catalase, malondialdehyde and nitric oxide were evaluated. Histological analysis of the liver was investigated. Results: A unique daily administration of ethanol during 14 days provoked a significant increased of transaminases, ALP, bilirubin, lipid profile, oxidative status and a significant decreased in serum and hepatic proteins. In addition, histopathological analysis revealed hepatic inflammation, steatosis and vascular congestion. The administration of the extract brought transaminases towards normal values. Bilirubin, ALP, lipid profile, protein and oxidative status were improved. The plant extract at all doses prevented the development of different abnormalities on hepatic tissue. Conclusion: The aqueous extract of D. integrifolia leaves improve the hepatic function in ethanol-induced hepatic damage, probably due to its antioxidant properties. These findings justify the traditional use of this plant in the management of liver problems.
 
 
 
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