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Articles by Maysam Mard-Soltani
Total Records ( 4 ) for Maysam Mard-Soltani
  Maysam Mard-Soltani , Mohammad Reza Dayer , Ghasem Ataie , Ahmad Ali Moazedi , Mohammad Saaid Dayer and Sayed Mohammad Reza Alavi
  Diabetes mellitus is the major risk factor for vascular diseases presumably by inducing hypercoagulable state leading to thrombotic plaque in small blood vessels. There are miscellaneous reports showing the intervention of some coagulation factors/co-factors, especially I, II, V, VII, VIII, IX, X, XI, vonWillebrand and tissue factor in micro and macrovascular complications. In the present we used 40 uniformed NIDDM patients and 21 healthy volunteers as control for the study. Based on the results obtained for coagulation tests such as PT, APTT and the specific activity or concentration determination for factors I, II, V, VII, VIII, IX, X, X and von Willebrand, we made a new comprehensive comparison between NIDDM and healthy groups. Present results show the major interference of intrinsic and common pathway of coagulation cascade factors and less of extrinsic pathway in hypercoagulability state in NIDDM patients. Present results show that there are significant increase (p<0.05) in plasma activities of coagulation factors, FII, FIX, FXI in intrinsic and common pathways and significant decrease in activity of factor VIII and prolonged prothrombin time in NIDDM patients (n = 40) in contrast to normal controls (n = 21). This finding leads us to conclude that this pattern could be used as diagnostic criteria for the presence of hypercoagulable state and as prognostic tools for susceptibility to vascular disease in NIDDM patients. Second, our findings in conjunction with patients history indicates that the presence of hypercoagulable state is not sufficient to induced vascular problems in NIDDM and instead it need additional triggering factors to initiate vascular thrombotic problems e.g., endothelium damage.
  Maysam Mard-Soltani , Mahnnaz Kesmati , Lotfolah Khajehpour , Abdolrahman Rasekh and Abdolhosein Shamshirgar-Zadeh
  Many studies have shown that anxiety-like behaviors are influenced by peripheral and central parameters including hormones and neurotransmitters in the different areas of Central Nervous System (CNS). Many investigations have proven the anxiolytic effect of androgens in different methods. Also, there are many reports about the modulating role of the amygdala complex, especially Basolateral Amygdala (BLA), through adrenergic system on anxiety. Among various types and subtypes of adrenergic receptors, β-1 adrenoceptors (β-1 ARs) of BLA account for the anxiety. The purpose of this study was to examine the relationship between testosterone and β-1 ARs in the BLA as an anxiety regulating key of CNS. Using Elevated plus Maze (EPM), the anxiety-like behaviors of four groups of intact adult male Wistar rat were assessed in the presence of different doses of testosterone (0, 20, 30 and 40 mg kg-1, Intraperitoneal (i.p.). Then, the effects of intra-BLA microinjection of different doses of betaxolol, a selective β-1 ARs antagonist, (0, 0.025, 0.1 and 0.4 μg rat-1), were evaluated in the other four groups. Finally, the interaction between the ineffective dose of testosterone via i.p. and betaxolol via intra-BLA was investigated. The results obtained revealed that testosterone (i.p.) and betaxolol (intra-BLA) alone had anxiolytic effects on the male Wistar rats in a dose-dependent manner. Our findings also showed that the anxiolytic effects of testosterone (i.p.) were reinforced by the intra-BLA injection of betaxolol. Co-administration betaxolol and testosterone also showed the synergistic actions on anxiolytic effects in the adult male Wistar rats. Our results interestingly proposed that the interaction between testosterone and β-1 ARs is in part related to common mechanism and other neurotransmitters include gamma-aminobutyric acid (GABA) and serotonin.
  Maysam Mard-Soltani , Mohammad Reza Dayer , Abdolhosein Shamshirgar-Zadeh , Hamid Ali-Bahar and Zahra Nasirbagheban
  Diabetes mellitus as a heterogeneous disease along with hyperglycemia causes quite many acute and chronic complications including cardiovascular complication. Cardiovascular complications are caused because of numerous factors such as increased Fasting Blood Sugar (FBS), Triglyceride (TG), hypercholesterolemia, hypercoagulable state and a change in balancing lipoproteins including Low Density Lipoproteins (LDL) and High Density Lipoproteins (HDL). Because of probable role of HDL in prevention of cardiovascular complications and its antithrombotic role in diabetics, we have studied lipoproteins and HDL in particular, effect on coagulation parameters which may potentially lead to cardiovascular complications in type 2 diabetics. In this study, 60 type 2 diabetics in early stage of diabetes were compared statistically with 50 healthy subjects in terms of biochemical factors of: FBS, TG, VLDL, LDL, coagulation parameters of: Partial thromboplastin time (PT), Activated Partial Thromboplastin Time (APTT), specific activity of coagulation factors and then the correlation between the biochemical and coagulation parameters was measured using Pearson’s correlation coefficient. Our findings showed that FBS, TG, VLDL and coagulation factors of: II, IX, X, XI in diabetics had increased significantly compared with healthy subjects. They also indicated that APTT and therefore, the intrinsic coagulation pathway in diabetics prolonged in comparison with the healthy individuals. There were no other significant differences in the measured parameters between two groups. On the other hand, by studying biochemical and coagulation factors, it was shown that there was a positive significant correlation among FBS, cholesterol and HDL with the coagulation factors of II, V, IX, X, XI. There was, interestingly, a negative significant correlation between HDL and APTT. The observed correlation between coagulation factors and HDL, regardless of the no significant difference of HDL in the two groups, shows that probably the hypercoagulable state as a result of hyperglycemia led to plasma increase of HDL. In other words, HDL, probably, because of hypercoagulable state, intended to remove their destructive effects of hypercoagulable state and then correlated with them.
  Mohammad Reza Dayer , Maysam Mard-Soltani , Mohammad Saaid Dayer and Sayed Mohammad Reza Alavi
  Increased risk of vascular diseases in hypercoagulable states is assumed to be the major cause for prevalence of vascular problems in type 2 diabetes mellitus patient. The present study was undertaken to explore the basis underlying the correlation between the aforesaid three coagulation factors with reference to the relevant mechanistic findings using statistical calculation. Our findings showed that the correlation between each pairs of coagulation factors, FV, FVIII and vWF could be easily interpreted using previously characterized interactions between these factors. Also, given the sequence similarities between FV and FVIII as well as the results of this study, it was indicated, for the first time, that FV may bind to vWF in the same way as FVIII binds. This finding seems to be of great importance to be evaluated through experimental techniques.
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