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Articles by Mayada Ragab Farag
Total Records ( 7 ) for Mayada Ragab Farag
  Mahmoud Mohamed Alagawany , Mayada Ragab Farag and Kuldeep Dhama
  The present study was planned to evaluate the effects of turmeric (Curcuma longa) for protection against alterations resulted from exposure to endosulfan in broiler chicks. A total of 180 day old chicks were divided into 6 groups of 30 chicks with 3 replicates. First group was fed basal diet while the other five groups were fed basal diet supplemented with 5 g turmeric, 10 g turmeric, 30 mg endosulfan, 30 mg endosulfan plus 5 g turmeric and 30 mg endosulfan plus 10 g turmeric/kg diet during the experimental period. Growth performance, carcass traits, blood parameters, oxidative status and viability of the broilers chicks were used as criteria of response. The results showed that endosulfan significantly decreased the levels of Total Protein (TP), albumin (ALB), globulin (GLB), HDL-cholesterol, catalase (CAT), superoxide dismutase (SOD) activity and reduced glutathione (GSH) concentration but significantly increased albumin/globulin (A/G) ratio, total cholesterol (TCHO), LDL-cholesterol, triglyceride (TRG), malondialdehyde (MDA) concentration and hepatic transaminases (alanine amino-transferase, ALT and aspartate amino-transferase, AST) and exhibited different alterations to the hepatic structure in comparison with control and both turmeric groups. Dietary supplementation of turmeric at different levels could ameliorate these effects but not restored to control level. It is recommended that regular consumption of turmeric in the diet of broiler chicks provides a constant supply of potential antioxidants that could reduce these alterations.
  Mayada Ragab Farag , Mahmoud Alagawany and Kuldeep Dhama
  Objective: The present study was designed to investigate the hepatic and renal toxicity of acephate (ACE) insecticide in broiler chicks by studying the hematological, biochemical, oxido-inflammatory and pathological changes after subacute exposure to ACE in diet and to evaluate the modulatory role of flaxseed oil (FSO) on these changes. Materials and Methods: Two hundred and forty day-old un-sexed broiler chicks (average body weight of 45.52±0.25 g) were randomly assigned into 4 groups with 4 replicates of 15 chicks based on a completely randomized design. The first group was fed a basal diet, 2nd group fed basal diet supplemented with 85.2 ppm acephate, while the 3rd group fed basal diet supplemented with 1000 ppm flaxseed oil, while the 4th group fed basal diet supplemented with 85.2 ppm ACE+1000 ppm FSO for 4 weeks. Results: The ACE significantly (p<0.05) decreased hemoglobin content, erythrocytic count and packed cell volume while increased white blood cells, lymphocyte and granulocyte counts. Moreover, there was a significant increase in lipid profile (total cholesterol, LDL and triglyceride) and serum biomarkers related to hepatic and renal functions including aspartate transaminase (AST), alanine aminotransferase (ALT), urea and creatinine with no change in alkaline phosphatase (ALP) and albumin while, serum total protein, globulin and HDL-cholesterol levels were significantly reduced with ACE group in comparison with other treatment groups. The ACE significantly (p<0.05) decreased the antioxidant capacity of liver and kidney and increased lipid peroxidation, interleukine-2 (IL-2) tumor and necrosis factor-alpha (TNF-α) in the two organs while increased the activity of cytochrome P450 in liver only. Diet supplemented with FSO showed promising modulatory effects on these undesirable changes however, some did not restored to normal levels. Conclusion: It is recommended to use FSO regularly as a dietary supplement for broiler chicks to provide them powerful antioxidants required to protect these birds against environmental pollution.
  Mahmoud Alagawany , Mohamed Ezzat Abd El-Hack , Mayada Ragab Farag , Ruchi Tiwari , Swati Sachan , Kumaragurubaran Karthik and Kuldeep Dhama
  Protein plays an important role in the diet formulation of poultry to maintain/improve growth, feed utilization, immune functions and maximize productive performance, ensure bird welfare, as well as mitigate environmental risks and pollution by optimizing the use of this nutrient. Also, proteins assist in the biosynthesis of tissues and have many biological functions for growth and renewal of the body. Moreover, proteins exist in forms of hormones and enzymes which play crucial roles in the physiological processes in the body. Layer birds have low dietary Crude Protein (CP) requirements, thus identification of the optimum level of CP in layer diets, for either maximizing productive performance or economic returns of laying hens, requires more and more information/knowledge about birds needs of protein and its impacts on performance parameters and environmental pollution. This biomolecule plays active role in physiological dynamics, in stabilizing the immune barrier and to drive the forces for maintaining the enhanced production performance of layers. The broad goal of the current review is to highlight the importance of CP-diet and its positive and negative effects on body weight change, performance, feed and nutrient utilization, egg production parameters, egg quality criteria as well as chemical composition of egg and its fractions, egg shell quality, blood biochemical parameters, immune function, nutrient digestibility and nitrogen pollution. The discussed concepts and knowledge would be useful for both backyard poultry rearers and poultry industry holders by optimizing the level of crude protein in the fed diet and will definitely be helpful for gaining the economic profits and consumers satisfaction.
  Mayada Ragab Farag , Mahmoud Alagawany , Mohamed Ezzat Abd El-Hack and Kuldeep Dhama
  Spirulina (Arthrospira) is a microscopic blue-green algae and it is considered as one of the richest sources of organic nutrients that are making it a good nutritional supplement for human and animal feed worldwide. Spirulina contains good quality proteins, vitamins and minerals in addition to a wide variety of natural carotene and xanthophyll phytopigments. Owing to its unique and impressive nutrient composition, Spirulina is used as a dietary inclusion in a large scale of food products not only to enhance their nutritional qualities but also for therapeutic purposes. On this aspect, many researchers studied the beneficial effects of Spirulina and reported its enhancing potential on the productive and reproductive performance, improving general health as well as lowering the problems of different animal diseases like arthritis, diabetes, anaemia, hypertension and cardiovascular disorders. Other studies have demonstrated that Spirulina possess some promising biological activities such as antitumor, antimicrobial, antiviral, anti-inflammatory, hypocholesterolemic, radio protective and metalloprotective effects. These pharmaceutical and medicinal properties of Spirulina could be attributed to some natural constituents such as phycocyanin, carotene, tocopherols, linolenic acid and phenolic compounds that had been shown to have strong antioxidant properties and powerful scavenging activities against Reactive Oxygen Species (ROS) like superoxide and hydrogen peroxide radicals. This review illustrates the beneficial effects of Arthrospira on poultry, animals and human health and throws the light on its ability to protect the body physiological system against oxidative damage and as nutraceutical and source of potential pharmaceuticals based mainly on the highest levels of evidence available in the literature.
  Mohamed Ezzat Abd El-Hack , Mahmoud Alagawany , Mayada Ragab Farag , Ruchi Tiwari , Kumaragurubaran Karthik and Kuldeep Dhama
  In the present era of emerging antibiotic/drug resistance against pathogenic organisms and food safety concerns of their toxic residues as well as slow process of discovering newer antibiotics, there is a dire need for using natural and effective alternatives. In this regard, herbal and aromatic plants and/or their extracts are gaining attention of worldwide researchers. Studies on Nigella sativa (black cumin) seeds show promising results that it could provide a suitable alternative to antibiotics as growth promoter and safeguard various health issues of animals and humans. The seeds of black cumin with thymoquinone as its main active constituent are mainly used for medicinal purposes and could be used as food spice and nutritional supplements. These have beneficial antinociceptive, antimicrobial, growth enhancing, antiparasitic, immunomoulatory, hepatoprotective, analgesic, anti-inflammatory, antioxidative and bronchodilating effects. Blood pressure regulating as well as bile flow stimulating effects have also been observed. Black cumin seeds have been used widely against several diseases, disorders and ailments of humans and animals including bronchial asthma, cough, bronchitis, lung inflammation, microbial infections, fever, dysentery, gastrointestinal problems, gastric ulcers, hypertension, neurodegenerative diseases, epilepsy, alzheimer disease, headache, diabetes, allergy, obesity, back pain, skin diseases, eczema, jaundice, anorexia, conjunctivitis, dyspepsia, rheumatism, diabetes, intrinsic hemorrhages, amenorrhea and immune disorders, which altogether indicate their potent therapeutic values and biomedicinal perspectives. The aim of this study is to provide comprehensive and recent information about the nutritional, healthical, pharmaceutical, therapeutic and biomedical applications and prospects of Nigella sativa seeds in feeding humans, animals and poultry.
  Mahmoud Alagawany , Mayada Ragab Farag , Mohamed Ezzat Abd El-Hack , Elisabetta Casalino , Vincenzo Tufarelli , Maryam Sayab and Kuldeep Dhama
  Objective: The current study was conducted to assess the biological in vitro impacts of cyadox (CYA) as growth promoter on erythrocytes isolated from rabbits. Methodology: Suspensions of erythrocytes were divided into 6 groups (5 replicates each), 1st group served as control; 2nd, 3rd, 4th, 5th and 6th groups were respectively subjected to CYA at 2.5, 5, 10, 20 and 40 μg mL–1, then incubated for 3 and 6 h at 37°C and shaken gently from 3-4 times per hour. Results: The data obtained revealed that the low doses of CYA (2.5 and 5 μg mL–1) diminished the reduced glutathione (GSH) content and enhanced the catalase (CAT) and superoxide dismutase (SOD) activities even after incubation with CYA for 6 h. These concentrations also had no linear or quadratic influences on the values of malonaldehyde (MDA) and protein carbonyl (PrC) as well as the hemoglobin (Hb), adenosine triphosphate (ATP) and total protein (TP) levels in erythrocytes. Increasing the concentration of CYA (10, 20 and 40 μg mL–1) and increasing the incubation period resulted in depletion of GSH, inhibited the CAT and SOD activities and decreased the protein content in the treated RBCs while the levels of PrC, MDA, Hb, TP and ATP were increased in response to increasing the dose and incubation time. Conclusion: From these results it could be concluded that CYA may be safe at recommended doses (2.5 and 5 μg mL–1) while using at high concentrations revealed pro-oxidant properties which could in turn affect cell survival.
  Mayada Ragab Farag , Mahmoud Alagawany , Mohamed Ezzat Abd El-Hack , Muhammad Arif , Tugay Ayasan , Kuldeep Dhama , Amlan Patra and Kumaragurubaran Karthik
  Chromium (Cr) is one of the essential minerals which is required for improving productive performance in poultry due to its important functions in metabolism, growth and reduction of lipid and protein peroxidation. Under heat stress conditions, Cr plays a crucial role in poultry nutrition, production and health as well as enhances growth performance and quality of eggs in meat and egg type chickens, respectively. Supplementation of Cr may increase body weight gain, improve feed efficiency and there is also increase in carcass yield of broilers. Chromium is also a potent hypocholesteremic and antioxidant agent. The beneficial impacts of Cr have been linked with improved the metabolism and immune system. Dietary addition of Cr has promising impacts on the immune system through increasing relative weights of lymphoid organ such as thymus, spleen and bursa of Fabricius, declined heterophil/ lymphocyte (H/L) ratio, enhancing the Cell Mediated Immune (CMI) response and improving the antibody response versus the infectious diseases. Dietary supplementation of Cr may stimulate the secretion of digestive enzymes by improving the functions of liver and pancreas. Chromium present in many forms differs greatly in stability and oxidation states; therefore the added forms and concentrations should be managed well. Further, the increase in Cr dose in the diet could produce hazardous and toxic influences in chickens as well. This paper illustrates the positive and negative impacts of Cr including its physical and chemical proprieties, practical applications in poultry nutrition, production, enhancing immunity and health and a special reference to its toxic effects.
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