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Articles by Mayada R. Farag
Total Records ( 4 ) for Mayada R. Farag
  M. Alagawany , Mayada R. Farag , M.S. El-Kholy , S.A.A. El-Sayed and K. Dhama
  Objective: Three separate experiments were performed to evaluate the biological in vitro effects of two natural antioxidants, resveratrol (RES), cinnamaldehyde (CIN) and their combinations (RES+CIN) on rabbit erythrocytes. Materials and Methods: Suspensions of erythrocytes were divided into 15 groups (each group contains 5 replicates). In three experiments, control group was treated with phosphate buffered saline and dimethyl sulfoxide (DMSO) under the same concentration, while the phytochemical groups in the three experiments were 25, 50, 75 and 100 μM of RES or CIN or their combinations (equal mixture of RES and CIN) added to the control group, respectively and incubated for 3 h at 37°C and exposed to gentle shaking every 15 min. Results: The RES or CIN separately or in combination at different doses enhanced the activities of superoxide dismutase and catalase and improved the concentration of reduced glutathione compared to the control group. Malondialdehyde, protein carbonyl and adenosine triphosphate contents showed linear and quadratic decrease with increasing the concentration of RES or CIN or their combinations. Conclusion: The tested bioactive compounds (RES+CIN) could be helpful in improving the body cells functions without causing hazardous effects and efficiently protected the cells against oxidative injury when used at concentrations up to 100 μM and found to have synergistic effects.
  Mayada R. Farag , Mahmoud M. Alagawany and Kuldeep Dhama
  This study was conducted to verify whether Turmeric (Curcuma longa) has the potential to modulate the cytogenotoxic and immunotoxic effects resulting from exposure to endosulfan in broiler chicks. For this purpose, 180 one day old chicks were divided randomly into 6 groups of 30 chicks each, divided into 3 replicates. First group was fed basal diet, while the other five groups were fed basal diet supplemented with 5 g turmeric, 10 g turmeric, 30 mg endosulfan, 30 mg endosulfan plus 5 g turmeric and 30 mg endosulfan plus 10 g turmeric/kg diet, respectively, during the experimental period. At the end of the experiment, blood and spleen samples were collected and evaluated for genotoxicity, cytotoxicity and immunotoxicity biomarkers induced by endosulfan. Also, histopathological investigation of the spleen tissue was conducted. A significant increase in genotoxicity and cytotoxicity biomarkers (micronucleusfrequency, DNA fragmentation, 8-hydroxy-2-deoxyguanosine level (8 OHdG) and lactate dehydrogenase activity (LDH)) was recorded in endosulfan treated chicks. In addition, the immunotoxicity biomarkers showed a significant decrease in phagocytic percentage, stimulated Nitric oxide (NO) production and decrease in the serum lysozyme activity. Histopathological findings supported the cytotoxicity results. Dietary supplementation of turmeric at different levels ameliorated deleterious effects of endosulfan and restored them to be near control level. The results of the study suggested that regular consumption of turmeric in the diet is a promising approach in attenuating the disturbances induced by endosulfan in the most studied biomarkers.
  Kuldeep Dhama , Shyma K. Latheef , Saminathan Mani , Hari Abdul Samad , K. Karthik , Ruchi Tiwari , Rifat Ullah Khan , Mahmoud Alagawany , Mayada R. Farag , Gazi Mahabubul Alam , Vito Laudadio and Vincenzo Tufarelli
  Herbal medicine or herbalism is a time-honored practice of natural medicine that is older than mankind itself. The practice of using traditional herbal medicine based therapy is nowadays gaining more attention worldwide in both human and animal health care systems. Among the livestock sectors, poultry production systems are the most intensively reared with developments especially in the areas of nutrition, disease control, genetic improvement, management and organization of dietary requirements along with the pressure of increasing demand for poultry products as well as threats of emerging pathogens. So this sector is badly in need of sustainable therapeutic and production aids especially based on herbs because of the advantages like, low cost, easy availability, no residual effect, free from the threat of antibiotic resistance etc. Many herbs have been recorded to be fruitfully used by veterinarians to treat a variety of disease conditions in animals. The present study discusses the various useful and practical applications of the rich heritage of herbal wealth for safeguarding poultry health in general, combating infectious as well as non-infectious diseases caused by microbes and parasites )both ecto-and endo parasites( along with immunomodulatory actions for countering immunosuppressive diseases. Moreover, highlighting herb-based poultry growth promoters for increasing production performances use of herbs as antioxidants and their role in organic egg and meat production is a special attraction of the review that will draw the attention of the poultry specialists as well as farming community. The information will be useful to increase poultry production and protect the health of birds in a better way from traditional ways towards modern perspectives and also would promote and popularize usage of herbs amongst poultry producers.
  Mahmoud M. Alagawany , Mayada R. Farag , Kuldeep Dhama , Mohamed E. Abd El-Hack , Ruchi Tiwari and Gazi Mahabubul Alam
  The polyphenol resveratrol is an antioxidant nutrient, used to enhance growth performance through activation and modification of gut function and structure and to inhibit cancer initiation and promotion. The main application of resveratrol is in animal and poultry nutrition, in particular as a feed additive to reduce free radicals in a wide variety of animal species. Several studies carried out on diets supplemented with additives containing natural antioxidants as resveratrol demonstrated its capability to improve the productive performance, immune response and health of livestock besides reducing the risks of various animal diseases such as cancer and other degenerative diseases. Such activities could be attributed to its powerful antioxidant, immunomodulatory and anti-inflammatory effects by preventing free radicals from interacting with cellular DNA and its ability to alter the intestinal microbiota, increased digestibility and absorbance of nutrients. This review describes the modes of action, metabolism, the biological activities, natural sources and beneficial aspects/potential applications of resveratrol in animal and poultry nutrition, production and health.
 
 
 
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