Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by Masoud Khoshnia
Total Records ( 2 ) for Masoud Khoshnia
  Azam Shafaei , Masoud Khoshnia and Abdoljalal Marjani
  Effect of FGF21 on metabolic syndrome patients is not exactly clear. In the present study, we assessed serum level of fibroblast growth factor 21 in type 2 diabetic patients with and without metabolic syndrome in Gorgan. The study groups consisted of 120 patients with type 2 diabetes and 60 healthy subjects. Diabetic patients divided into two groups. All subjects were matched according to age and sex. The mean waist circumference, systolic and diastolic blood pressure, triglyceride and fasting blood glucose levels and body mass index were significantly higher in the subjects with metabolic syndrome than control group, but the mean HDL-cholesterol was significantly lower (p = 0.0001). Mean serum level of FGF21 was higher in type 2 diabetic subjects with and without metabolic syndrome than that of control subject (p = 0.0001). There were significant negative correlation between FGF21 and BMI, diastolic blood pressure and HDL-cholesterol in subjects with metabolic syndrome (p<0.05). There were also significant negative correlation between FGF21 and cholesterol and HDL-cholesterol in control group (p<0.05). The findings of this study suggest that serum FGF21 are higher in patients with type 2 diabetes with and without metabolic syndrome than in age and sex matched control group. Our study shows that some of metabolic syndrome components (especially HDL-cholesterol) are associated with high serum FGF21 levels. Because of different effects of FGF21 in rodents, primates and in humans, it may require more investigating on metabolic effects of FGF21 in human’s samples.
  Tayebe Beigi , Azam Shafaei , Masoud Khoshnia and Abdoljalal Marjani
  Some studies have indicated that increased levels of liver enzymes may associate with development of diabetes in future. The association between liver enzymes and type 2 diabetes are inconsistent and may depend on the ethnic difference among different populations. The aim of present study was to assess serum Fetuin A level, liver enzymes activities and insulin resistance in patients with type 2 diabetes in Gorgan. The study groups consisted of 75 type 2 diabetic patients and 75 control subjects. Both subjects were matched for age and sex. Different parameters were in the Metabolic Disorders Research Center. There were significant differences in the mean value of glucose, triglyceride, Low Density Lipoprotein (LDL), Alanine Transaminase (ALT), γ-glutamyltransferase (GGT), insulin, HOMA-IR and fetuin A when type 2 diabetic patients compared with control groups. There were significant negative correlation between fetuin A and age in subjects with type 2 diabetic patients and control groups (p<0.05). The present study showed that serum fetuin-A levels are significantly increased in type 2 diabetes mellitus. Our findings show that studied liver enzymes were higher in type 2 diabetic patients than control groups. The relationship of liver aminotransferase levels and risk of type 2 diabetes development seems to be complex. Increased levels of fetuin-A and studied enzymes in subjects should be an alert for further clinical evaluation and screening.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility