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Articles by Masoud Hemadi
Total Records ( 6 ) for Masoud Hemadi
  Mohammad Reza Gholami , Ghasem Saki , Masoud Hemadi , Ali Khodadadi and Javad Mohammadi-Asl
  The purpose of this study was to test of efficacy of melatonin on the Optimizing of cryopreservation media in the testis tissue samples. Testes from neonate BALB/c mice were vitrified and then thawed under standard condition with or without the addition of 100 μM melatonin to both of vitrification and thawing solution. After that, Vitrified-thawed whole testes were digested under standard condition and subsequent viability of the cells in the suspension was analyzed using cytotoxicity kit and Apo-Brdu tunnel assay kit. The mean proportion of apoptotic testicular cells in the treated vitrified-thawed testes in comparison to no-treated ones was noted significantly (5.2±0.47 vs. 1.56±0.62, respectively). Moreover, melatonin cause decreasing the viability of the treated vitrified-thawed testicular cells in compared to no-treated vitrified-thawed testicular cells (4.78±0.46 vs. 8.39±0.76, respectively). In addition, the mean cytotoxicity of melatonin on the vitrified-thawed testicular cells was 9%. The associated reduction in healthy testicular cells in the treated vitrified-thawed testes suggests that melatonin in doses of 100 μM don’t protected testicular tissue from damaged induced in the process vitrification and thawing. However, further well-designed studies such as dosimetry melatonin and applied another cryoprotectants in the matching with melatonin are essential to offer a final conclusion.
  Mahvash Zargar , Taghi Razi , Mahjobeh Ghanbarnejad and Masoud Hemadi
  The purpose of this study was investigated that whether the measure of the biochemical and urine parameters in pregnant women has correlation relationship with preeclampsia. This study was targeted singleton pregnant women as the case group (50 patients of preeclampsia) or the control group (50 healthy parturients) who were admitted for termination of pregnancy due to medical or obstetrical indications. In order to survey of serum iron, ferritin, creatinine, platelet and liver enzymes, blood samples of case and control groups were taken before delivery and analyzed. There was significant difference in the mean serum iron and ferritin levels between two groups. Also, it was found significant differences in the mean level of serum ferritin of the preeclamptic patients who have ELLP syndrome (EL: Elevated liver enzyme, LP: Low platelet count) in comparison with preeclampsia women with high level of liver enzymes. However, this relation meaningful was not shown among mean serum iron and EELP syndrome with preeclampsia. The correlation coefficients between iron and creatinine/proteinuria/albuminuria as well as ferritin and creatinine/proteinuria/albuminuria concentrations in group of preeclampsia were not significantly different. Present results revealed that a correlation relationship between the concentration of serum ferritin and iron and ELLP syndrome and preeclampsia may in fact exist.
  Roshan Nikbakht and Masoud Hemadi
  The purpose of this study was to compare the effectiveness of two doses of recombinant hCG (500 and 250 μg) on the reproductive outcome through triggering of oocyte maturation. The study was a randomized controlled clinical trial. Healthy women undergoing IUI cycles (n = 66) were randomly assigned to one of two groups at the start of the cycle. Group control (n = 33) received rhCG (250 μg) and group experiment (n = 33) received rhCG (500 μg). Controlled ovarian hyperstimulation was achieved using clomiphene or letrozole and hMG. Semen specimens were washed using the swim up method and IUI using a volume of 0.3 mL was performed 42 h after rhCG injection. No difference was shown in terms of obtained total follicles and pregnancy rate in both groups. However, when all of the cycles who given 250 or 500 μg of rhCG were stratified by the BMI (more and less than 25 kg m-2), Total follicles (more and less than 2 follicles) and infertility duration (more and less than 5 years), the reproductive outcome in the patients with less than 5 years infertility duration and less than 25 kg m-2 BMI was more pronounced than the patients with more than 5 years infertility duration and more than 25 kg m-2 BMI but the other parameter was not affected the reproductive outcome. No clinical or statistical improvement could be demonstrated, except infertility duration and BMI, for the higher dose of recombinant hCG in women. However, further well-designed studies are essential to offer a final conclusion.
  Farideh Moramezi , Taghi Razi , Afshan Amirshaghaghi and Masoud Hemadi
  The purpose of this study was investigated that whether the measure of the uric acid in pregnant women has cause-effect relationship with severity of preeclampsia, biochemical and urine parameters. This study was targeted the preeclampsia women with uric acid levels = 6 mg dL-1 and < 6 mg dL-1 for comparing with healthy pregnant women. In order to survey of serum Hb, platelet, liver enzymes and renal function test findings, blood and urine samples of preeclampsia and healthy groups were taken before delivery and analyzed. There was significant differences in the gestational age and mean serum AST, ALT, BUN and urine albumin between preeclampsia groups and healthy women. Also the gestational age variable in preeclampsia women with uric acid levels = 6 mg dL-1 were lower than preeclamptic patients who have lower than 6 mg dL-1 uric acid. Systolic and diastolic blood pressure were higher in the both preeclampsia cases compared with control group. There was significant differences in Apgar scores in the first and fifth minutes of life between the preeclampsia groups and healthy women. Also Apgar score in the fifth minutes of life has a significant effect on the risk of preeclampsia with more than 6 mg dL-1 uric acid compared with preeclampsia with less than 6 mg dL-1 uric acid. Neonatal weight in the preeclampsia groups were lower than its levels in the control group. In conclusion our results declared that a cause-effect relationship between the secretion of serum uric acid and severity of preeclampsia, biochemical and urine parameters may in fact exist.
  Farideh Moramezi , Mojgan Barati , Razieh Mohammadjafari , Sara Barati and Masoud Hemadi
  Uterinedisorders like usual infertility factors (male factor, ovarian and tubal problems of women) may affect the outcome of infertility treatment in infertile patients. In our clinical trial, 110 couples diagnosed with infertility were candidate for Intra Uterine Insemination (IUI). The patients were divided randomly into two equal groups (n = 55): In group one (control group), patients without hysteroscopy underwent ovulation induction by clomiphene citrate and hCG followed by intrauterine insemination. The second group (experiment group), patients were undergoing hysteroscopy before intra uterine insemination on the day 21 of the cycle and due to abnormal findings, going under surgical treatment if they needed. The rates of pregnancy complications in patients were evaluated. The age, BMI, kind of infertility, duration of infertility, number of previous trial, duration of stimulation, the type of procedures used and semen analysis (TMC, Motility and morphology of sperm) were similar for both groups and no statistically significant differences emerged at all between them. In experimental group, hysteroscopy revealed pathology in the uterine cavity in 26 out of 55 cases. The overall rates of clinical pregnancy were higher in experimental group compared to the control group. The findings from this study showed that the use of hysteroscopy as a diagnostic or therapeutic procedure before IUI, can increase the rate of pregnancy and finally decrease the failure rate of infertility treatment and perinatal complications in infertile couples.
  Maryamalsadat Jalali , Masoud Hemadi , Ghasem Saki and Alireza Sarkaki
  Noise stress is dangerous natural contaminant that produces harmful physiological, psychological and morphological outcomes to the body. So this study was conducted in order to investigate the effects of noise stress on the parenchyma of testis. Healthy mature females rats (n = 20) were mated with the mature male rats and then randomly allocated equally either to experimental or control groups. Experimental group has given daily noise stress up to birth their child. In the second step, the child's pregnant rats of experimental group were distributed to three subgroups as follow: group I (without exposure to noise stress), group II (exposure to noise for 8 weeks) and group III (exposure to noise for 14 weeks) for morphometric analysis of their child's testicles by sacrificing of them at weeks 14. In general, the testes of non-exposed group were grown larger than ones in the noise exposed groups. Moreover, the testes of the experimental group 1 were larger than the other experimental groups. Indeed, the rate of atrophic seminiferous tubules and jumbled appearance of the interstitial space were more observed in the noise stress exposed group than non-exposed ones. In addition, seminiferous tubules analysis revealed that the characteristics of interstitial space cells and epithelial germinative cells of the seminiferous tubules in the control group were better than the noise exposed groups. It seems that the noise stress has negative influences on the fertility of male based on enhancing of the apoptotic process induced by pathogenesis stress and suppressing the kinetics spermatogenesis.
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