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Articles by Maryati Mohamed
Total Records ( 5 ) for Maryati Mohamed
  Farrawati Sabli , Maryati Mohamed , Asmah Rahmat , Halijah Ibrahim and Mohd Fadzelly Abu Bakar
  In this study, total phenolic and flavonoid contents as well as antioxidant properties of methanolic extracts of rhizomes and stems of four Zingiberaceae (Etlingera belalongensis, Etlingera velutina, Zingiber vinosum and Zingiber pseudopungens) were investigated. Evaluation of antioxidant activity was conducted using 1,1-diphenyl-2-picrylhydrazyl free radical-scavenging (DPPH) assay, 2-2’-azinobis-3-ethylbenzothioazaline-6-sulphonate radical scavenging (ABTS) assay and Ferric-Reducing Antioxidant Power (FRAP). The results showed the total phenolic and total flavanoid contents were in the range of 5.3-41.7 mg gallic acid equivalent/g and 1.09-5.86 mg catechin equivalent/g of dry sample, respectively. The antioxidant activities of the extracts as assessed by using DPPH and FRAP assays were strongly correlated with all phytochemical tested (p<0.05). As a conclusion, selected tropical gingers found in Sabah investigated in this study can be developed as natural antioxidant agents.
  Arney Sapaat , Siti Fatimah Sabran , Nur Amalina Ismail , Izdihar Ismail , Maryati Mohamed and Mohd. Noh Dalimin
  The objective of this research was to document traditional knowledge of Jakun people on medicinal plants by using voucher specimens as a tools. The plants were collected together with biological information as well as how the plants were used. The collected plants than were pressed and dried in the oven. After that, the plants were mounted onto acid-free card and deposited in UTHM repository. A total of 28 plant specimens collected from 2014-2015 and deposited at UTHM were examined. Scientific name, local name, growth form, local use, part used, place of collection, year of collection and herbarium accession number of each species were recorded. A total of 26 species of medicinal plants were documented in this study. Total 26 genera and 24 botanical families were presented indicating that the medicinal plants were much diversified taxonomically. Most of the plants were taken orally by drinking the decoction. The results obtained in this research work indicates that by using a voucher specimens, one can know better about medicinal plants that been used by Jakun people in their daily live. Future investigation and proper documentation need to be done in order to preserve their knowledge from erosion.
  Siti Fatimah Sabran , Maryati Mohamed , Mohd Fadzelly Abu Bakar and Alona Cuevas Linatoc
  This study was aimed to profile the major phytochemicals constituents and to evaluate the antimycobacterial activity of hexane, ethyl acetate, absolute methanol, water and 80% methanol root extracts of ethnomedically used plants Thottea grandiflora Rottb. and Thottea grandiflora T.L. Yao (Aristolochiaceae) from Johor, Peninsular Malaysia. The hexane, ethyl acetate, absolute methanol extracts of T. grandiflora and T. praetermissa were screened for major class of compounds using qualitative TLC fingerprinting while the water and 80% methanol extracts were profiled using GC-MS analysis to screen for major phytochemical constituents. By using Mycobacterium smegmatis as the model strain for TB, agar disk diffusion assay and Resazurin Microplate Assay (REMA) were employed to evaluate for their antimycobacterial activity in vitro. Further, the mechanism of action were described for growth curve, cellular leakage and scanning electron microscopy studies. TLC fingerprinting showed both species displayed a slight difference in phytochemical groups. By GC-MS analysis, acetic acid, n-hexadecanoic acid, glycerin and oleic acid were detected as among 11 major constituents in both species that might contribute to the antimycobacterial activity. Ethyl acetate extract of T. grandiflora displayed the largest inhibition zone at 100 mg/mL (14.92±0.86 mm) followed by ethyl acetate extract of T. praetermissa (12.08±2.15 mm). About 80% methanol and ethyl acetate extracts of T. grandiflora displayed the lowest minimum inhibition concentration (3.13 mg/mL) while 80% methanol extract of T. grandiflora displayed the lowest minimum mycobactericidal concentration (3.13 mg/mL), followed by 80% methanol and ethyl acetate extracts of T. praetermissa (6.25 mg/mL). Growth curve analysis showed that at 2-fold of MIC, 80% methanol extract of T. grandiflora successfully inhibited the bacterial cell growth within 8 h of treatment by causing significant cellular leakage and severe damage to the cells. The results scientifically validated the plants used in Jakun’s traditional medicine displayed promising antimycobacterial properties and further studies would lead to the discovery of novel biomarker in Thottea species.
  Nur Amalina Ismail , Mohd Fadzelly Abu Bakar , Faridah Kormin , Alona C. Linatoc and Maryati Mohamed
  The objectives of this study were to model the extraction of Total Phenolic (TPC) and Flavonoid Content (TFC) from mixtures of Cnestis palala, Urceola micrantha, Labisia pumila and Microporus xanthopus and to determine the optimal formulation of the herbal mixture. The dried plant materials were extracted using hot boiling water extraction procedure. Samples (0.1 g) were infused in 200 mL boiling distilled water (100°C), stirred for 3 min using a magnetic stirrer, left to cool for 5 min and filtered using filter paper. Folin-Ciocalteu method and aluminium colorimetric method were used for measurement of TPC and TFC. About 24 formulations of herbal mixture were generated by using Design-Expert 9.0 Software. Quadratic and linear model were found to be the best model for describing the relationship between the proportion of polyherbs with the TPC and TFC. The optimal formulations were validate experimentally. The highest TPC and TFC were shown by single formulation of C. palala. The experiments reported in current study demonstrated that the application of statistical mixture design is an efficient tool to analyse the optimal formulation of herbal mixture.
  Ling Jing Jing , Mohd Fadzelly Abu Bakar , Maryati Mohamed and Asmah Rahmat
  The aim of this research was to determine the potential of Boesenbergia species collected from Sabah rainforest as anticancer remedy. This research was done to Boesenbergia rotunda, B. pulchella, B. pulchella var attenuata and B. armeniaca crude extracts on the in vitro proliferation of hormone-dependent breast cancer (MCF-7), non-hormone dependent breast cancer (MDA-MB-231), ovarian cancer (CaOV3), colon cancer (HT-29) and cervix cancer (Hela) cell lines. The effects of the four Boesenbergia species (methanol extracts of leaves, stem and rhizome part) on the proliferation of MCF-7, MDA-MB-231, CaOV3, HT-29 and Hela cell lines were measured using (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) MTT assay. The crude extracts with IC50 value less than 100 μg mL-1 were subjected to cell cycle analysis by using flow cytometry for DNA content determination. B. rotunda as positive control showed significant inhibitions towards all the cancer cell lines tested with IC50 ranging from 51.0±0.01 to 71.0±1.41 μg mL-1. The remaining Boesenbergia species only showed positive cytotoxicity activities against MCF-7 cell lines especially B. pulchella var attenuata with IC50 value 93.0±2.83 μg mL-1 and B. armeniaca with 94.5±0.71 μg mL-1. In cell cycle analysis, B. rotunda crude extract arrested cell at sub-G1 phase while B. pulchella var attenuata arrested cell at G2/M phase. From this study, it can be concluded that only B. pulchella var attenuata and B. armeniaca were effective against cellular proliferations of MCF-7. However, both species were not as effective as B. rotunda.
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