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Articles by Maryam Begum
Total Records ( 2 ) for Maryam Begum
  Sana Ullah , Maryam Begum , Kuldeep Dhama , Saeed Ahmad , Said Hassan and Ibrar Alam
  The current study was aimed to investigate the genotoxic effect of an organophosphate pesticide malathion in the gills of a freshwater teleost rohu, Labeo rohita using alkaline Single Cell Gel Electrophoresis (SCGE)/comet assay. The 96 h LC50 of malathion was estimated for rohu in a semi-static system and was found to be 5 μg L–1. Specimens of rohu were exposed to LC50 of malathion. Gill tissues were sampled after 24, 48, 72 and 96 h of exposure. DNA damage was evaluated by studying different indices, including tail length (μm), percentage of DNA in tail, tail moment and olive tail moment using TriTek CometScoreTM. A linear relation was observed between exposure time and DNA damage in the gill cells. The current study revealed malathion as a potent inducer of DNA damage and comet assay as a reliable and sensitive assay for investigating and detecting DNA damage in vivo, induced in fish by genotoxic pesticides. In order to conserve the vanishing populations of rohu in natural aquatic bodies across the country, indiscriminate use of genotoxic pesticides such as malathion should be minimized.
  Sana Ullah , Maryam Begum , Saeed Ahmad and Kuldeep Dhama
  The current study was designed to determine the genotoxic effect of endosulfan at sublethal concentrations (66, 50 and 33% of LC50, 1.5 μg L–1) in peripheral blood erythrocytes of an economically important indigenous Indian major carp Mori, Cirrhinus mrigala . A total of 180 fish were divided into four groups, each group received 45 individuals. Group 1st served as control (received no endosulfan), while group 2nd (0.5 μg L–1), 3rd (0.75 μg L–1) and 4th (1 μg L–1) were exposed to endosulfan. For investigating the induced DNA damage, the blood samples were collected from the caudal veins of the fingerlings in all the groups after 7, 14, 21 and 28 days of endosulfan exposure. Endosulfan induced DNA damage in all the treated groups at all concentrations, in terms of percentage of damaged cell (% damage cell) and Genetic Damage Index (GDI) based on visual classification of the extent of damage (Class 0-4) and cumulative tail length (μm). A concentration and time dependent increase was observed in DNA damage in the exposed groups, the highest damage was observed in group 4th (1 μg L–1) followed by group 3rd (0.75 μg L–1). Similarly, the highest level of DNA damage was observed in peripheral blood erythrocytes sampled after 28 days, followed by 21 days after exposure. The current study displayed the severe genotoxic potential of endosulfan in Cirrhinus mrigala , even at sublethal concentrations. Therefore, the indiscriminate and injudicious use of endosulfan should be strictly monitored and banned or at least controlled by the responsible governmental authorities.
 
 
 
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