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Articles by Maryam Baeeri
Total Records ( 7 ) for Maryam Baeeri
  Mojdeh Mohammadi , Shokoufeh Atashpour , Nazila Pourkhalili , Amir Nili-Ahmadabadi , Maryam Baeeri , Azadeh Mohammadirad , Shokoufeh Hassani , Shekoufeh Nikfar and Mohammad Abdollahi
  Increased oxidative stress plays a role in the pathogenesis of cellular death and β-cell failure. The aim of this study was to evaluate the action of different types of phosphodiesterase (PDE) inhibitors including milrinone (PDE-3), rolipram (PDE-4) and sildenafil (PDE-5) on viability, production of Reactive Oxygen Species (ROS) and secretion of insulin from isolated rat pancreatic islets. Pancreatic islets were carefully isolated and incubated in RPMI 1640 for 24 h. After overnight incubation, islets were picked up and divided into ten in each groups. Then, milrinone, rolipram and sildenafil at doses of 0.1, 1, 10 and 100 FM were added to islet groups and incubated for further 24 h. Then static insulin secretion at 2.8 and 16.7 mM concentrations of glucose, was tested. Then the viability of cells, level of ROS and insulin were examined. The results of static experiments showed that secretion of insulin increased significantly in response to glucose at both basic (2.8 mM) and stimulation (16.7 mM) levels by the lower doses of tested PDE inhibitors. The level of ROS at the lower doses of milrinone decreased. The viability of islets at the lower doses of all of PDE inhibitors were increased; however, viability at the higher doses of sildenafil and rolipram reduced significantly. Milrinone was the most effective PDE inhibitors on the function of isolated pancreatic islets. PDE inhibitors show the most significant anti-oxidative effects at lower doses. Concerning improvement of isolated islets function, PDE-3 inhibitor is the best among tested compounds. PDE inhibitors may help management of diabetes and facilitate conditions of islet transplantation.
  Mona Navaei-Nigjeh , Mahban Rahimifard , Nazila Pourkhalili , Amir Nili-Ahmadabadi , Mohsen Pakzad , Maryam Baeeri and Mohammad Abdollahi
  Oxidative stress is involved in complications of diabetes. This study investigated the hypothesis that the cerium oxide nanoparticle/sodium selenite combination can synergistically improve oxidative stress indexes in vital organs (kidney, heart, brain and lung) of diabetic rats. Diabetes was induced in overnight-fasted male Wistar rats via a single dose of streptozotocin (STZ, 60 mg kg-1). The effective doses of cerium oxide nanoparticle (60 mg/kg/day) and sodium selenite (5 μmol/kg/day) alone or in combination were administered for 14 days to diabetic rats. Rats with blood glucose of more than (300 mg dL-1) were selected and divided into six groups including vehicle control, STZ control, cerium oxide nanoparticles, sodium selenite, combination of cerium oxide nanoparticles with sodium selenite and metal form of cerium oxide. At the end of 2 weeks, organ tissues including brain, heart, lung and kidney of animals were removed and then oxidative stress markers including cellular Lipid Peroxidation (LPO), Total Antioxidant Power (TAP), Total Thiol Molecules (TTM) and Reactive Oxygen Molecules (ROM) were evaluated. Combination of cerium oxide nanoparticles and sodium selenite significantly reduced ROM and LPO levels in all the organs. The results of TTM showed an increase in all tissues expect the lung. TAP increased in combination group in all studied tissues expect the lung. The beneficial effect of cerium oxide nanoparticles/sodium selenite in diabetic rats is mediated through control of oxidative stress mechanisms. These effects were more noticeable in kidney, brain and heart.
  Mahnaz Khanavi , Marzieh Taheri , Afsaneh Rajabi , Saeed Fallah-Bonekohal , Maryam Baeeri , Azadeh Mohammadirad , Gholamreza Amin and Mohammad Abdollahi
  The aqueous, dichloromethane, ethyl acetate and methanol extracts of dried aerial fruiting parts of Centaurea bruguierana ssp. belangerana were investigated for hypoglycemic mechanism in diabetic rats. Diabetes was induced by intravenous administration of streptozotocin-alloxan. The methanol and ethyl acetate extracts were administered in a single effective dose of 200 mg kg-1 and dichloromethane and aqueous extracts were administered in a single effective dose of 400 mg kg-1. Blood glucose was determined every 1 h until 3 h post administration of the extracts. In the second experiment, the liver was surgically removed 3 h post treatment of diabetic rats with various extracts, homogenized and used for measurement of key enzymes of glycogenolysis (glycogen phosphorylase, GP) and gluconeogenesis (phosphoenolpyruvate carboxykinase, PEPCK). Treatment by dichloromethane, ethyl acetate, methanol and aqueous extracts and the glibenclamide, reduced blood glucose to 41.7, 55.0, 45.7, 29.5 and 34.5%, respectively. The aqueous extract showed the best effect in reduction of hepatic PEPCK activity (84.0%) and increased hepatic GP activity (134.5%), while glibenclamide showed 62.5 and 133.0% activity, respectively. None of the extracts affected blood insulin. Presence of sugar in dried aqueous extract could suppress the hypoglycemic effect during the first hour of the experiment. After 1 h, the hepatic mechanism overwhelmed and thus lowering effect in blood glucose appeared. The conclusion is that C. bruguierana ssp. belangerana is able to lower blood glucose via stimulation of hepatic glycogenolysis and inhibition of gluconeogenesis.
  Seyedeh Farnaz Ghasemi-Niri , Sara Solki , Tina Didari , Shilan Mozaffari , Maryam Baeeri , Mohammad Amin Rezvanfar , Azadeh Mohammadirad , Hossein Jamalifar and Mohammad Abdollahi
  Alteration of intestinal microflora has an important role in Inflammatory Bowel Disease (IBD) and probiotics by balancing microflora and modulating inflammatory cytokines seem effective in management of IBD. In the present study, two combinations of probiotics Lactobacillus casei (L. casei) plus Bifidobacterium bifidum (B. bifidum) or plus Saccharomyces boulardii (S. boulardii) were tested for their potential to prevent or treat experimental colitis in rats. Nine groups of animals including sham (normal group), control (vehicle-treated), dexamethasone as standard, treatment groups (oral administration of L. casei and mixture of (L. casei-B. bifidum and L. casei-S. boulardii after induction of colitis) and prevention groups (oral administrations of L. casei and mixture of (L. casei-B. bifidum and L. casei-S. boulardii before induction of colitis) were used. Tumor necrosis factor-α (TNF-α), myeloperoxidase (MPO) and lipid peroxidation (LPO) were determined in all groups. In treatment groups, histological scores and TNF-α, MPO and LPO levels attenuated significantly but colonic lesions in the prevention groups did not recover. The results revealed that, combination of L. casei-B. bifidum and L. casei-S. boulardii alleviated inflammatory parameters in colitis but these combinations were ineffective to prevent colitis. In addition, we found that mixture of probiotics is significantly more effective than L. casei group in improving barrier function of epithelium in experimental colitis model.
  Mahban Rahimifard , Mona Navaii-Nigjeh , Amir Nilli-Ahmadabadi , Nazila Pourkhalili , Maryam Baeeri , Azadeh Mohammadirad and Mohammad Abdollahi
  Glycyrrhizic Acid (GA) a major component of licorice, has been reported to have potent antioxidant effects and used widely throughout the world. In the present study, the effects of GA on the function, viability and level of Reactive Oxygen Species (ROS) in isolated rat pancreatic islets were evaluated. After Laparotomy, pancreas was removed and islets were isolated and incubated in RPMI 1640 for 24 h and then islets were separated. GA at logarithmic doses (1, 10, 100 and 1000 μM) were added to islets and incubated for 24 h and then static insulin secretion was tested. Also, viability of cells and their ROS level were determined using Mitochondrial Toxicity Test (MTT) and fluorometric assay. Then islets were stained by dithizone and observed under microscope. The results of MTT test indicated that rang of 1-100 μM of GA is safe. In the dose of 1000 μM, GA increased ROS and reduced viability of islets. GA at 1 μM significantly increased secretion of insulin via isolated islets in the presence of stimulation level of glucose (16.7 mM). Results of dithizone staining showed a reduction in live cells at high dose of GA. The LC50 study was done to determine the toxicity of GA on rat pancreatic islets and a 24 h LC50 of 15 mM was found. GA showed remarkable anti oxidative effects at low doses and improved islet’s viability and insulin secretion in stimulation level of glucose. Interestingly, high dose of GA induced oxidative stress and reduced function of islets. The results of the present study indicate that GA is a good candidate to be examined in islet transplantation procedures to maintain islets viable and functional.
  Amir Baghaei , Neda Hajimohammadi , Maryam Baeeri , Azadeh Mohammadirad , Shokoufeh Hassani and Mohammad Abdollahi
  Aluminum phosphide (AlP) intoxication is becoming a major concern worldwide due to its high mortality rate (30-100%) besides non-availability of effective antidote till date. The aim of present study was to determine the effect of IMOD, a novel mixed herbal medicine on energy depletion, oxidative stress and change of electrocardiographic (ECG) parameters in the heart tissue of the rats poisoned by AlP. IMOD at doses of 13, 20 and 30 mg kg-1 was administered intraperitoneally 30 min after gavage intragastric administration of AlP (0.25 LD50). Sodium bicarbonate was used as the control. After anesthesia, animals were rapidly connected to PowerLab® device for monitoring of ECG, blood pressure and heart rate for 180 min. At 24 h post treatment, rats were decapitated and hearts removed for evaluation of oxidative stress markers and production of energy. AlP ingestion led to significant heart rate and blood pressure decrement as well as ST variation and shortening of PR interval. Administration of IMOD normalized AlP-disturbed cardiovascular parameters. IMOD also restored heart energy via re-establishment of cellular ATP pool and elimination of oxidative stress markers. These findings confirm the potential benefits of IMOD as an effective treatment for acute AlP poisoning that remain to be trialed clinically.
  Haleh Talaie , Abdolkarim Pajoumand , Reyhaneh Panahandeh , Behjat Barari , Maryam Baeeri and Mohammad Abdollahi
  The aim of this study was to evaluate the status of serum IL-1b and TNF-α in depressed patients who treated or non-treated or poisoned with tricyclic antidepressants (TCAs) in comparison to healthy subjects. In this prospective comparative study, patients were selected from those admitted at Loghman-Hakim Hospital from August 2007 to January 2008. Serum level of IL-1b and TNF-α were compared among group of subjects (10 in each) of healthy subjects, TCA-poisoned patients, TCA-treated depressed patients and non-treated depressed patients. Demographic and clinical data were collected by a questioner filled out by a trained practitioner in daily clinical management. Blood was tested for liver function, blood cells, electrocardiography and arterial blood gases. Complete blood analysis and demographic data did now show significant change between groups. IL-1b level was higher among females. The group of depressed patients non-treated with TCAs showed higher serum levels of IL-1b and TNF-α than other groups. No significant difference was observed in IL-1b and TNF-α values among healthy control, depressed TCA-treated and TCA-poisoned groups. It is concluded that depression and gender may influence the production of cytokines while neither TCAs treatment nor its overdose affect IL-1b and TNF-α.
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