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Articles by Mary Astuti
Total Records ( 4 ) for Mary Astuti
  Fatma Zuhrotun Nisa , Mary Astuti , Agnes Murdiati and Sofia Mubarika Haryana
  Background and Objective: Breast cancer is the most frequently diagnosed cancer in women. Chemotherapy is the main method of breast cancer treatment but there are side effects. Carica papaya leaves is vegetable foods consumed by most people of Indonesia have potential as anticancer. The aim of this study was to investigate anti-proliferative and apoptotic induced effect of aqueous papaya leaves extracts on human breast cancer cell lines MCF-7. Materials and Methods: Inhibitory on cell proliferation was measured by MTT assay while apoptosis induction was measured using Annexin V. Results: The results showed that papaya leaf can inhibit the proliferation of human breast cancer cells MCF-7 with IC50 in 1319.25 μg mL–1. The IC50 values of papaya leaf extract was higher than the IC50 value quercetin and doxorubicin. Papaya leaf extract can also induce apoptosis of breast cancer cells MCF-7 about 22.54% for concentration 659.63 μg mL–1 and about 20.73% for concentration 329.81 μg mL–1. The percentage of cell apoptosis of papaya leaf extract lower than doxorubicin but higher than quercetin. Conclusion: This study indicated that papaya leaf extract have potential as anticancer through mechanism anti-proliferation and apoptosis induction.
  Nurhidajah , Mary Astuti , Sardjono and Agnes Murdiati
  The objective of this study was to evaluate the glycaemic property of diabetic rats after consumption of enriched pigmented rice. During the experiment, thirty 2.5-month-old male Wistar rats with 175-250 g body weights were divided into 6 groups (n = 6) and fed Mandel Handayani pigmented rice enriched with 2% kappa-carrageenan and anthocyanin extract from black rice (5 ml/100 g pigmented rice) and standard feed AIN 93 for maintenance. After 5 days of adaptation, diabetes was induce using STZ and nicotinamide and treatment was started 5 days afterwards for 6 weeks. The observed parameters were feed remains and efficiency, body weight, blood glucose level, serum insulin assayed using a rat ELISA insulin kit and Homa IR and Homa β analyses. The results showed that both pigmented rice and kappa-carrageenan and anthocyanin-enriched pigmented rice improved the glycaemic properties of diabetic rats, as indicated by increases in rat body weight of between 10.14 and 11.94%, with feed efficiency ranging between 13.62 and 17.39%, reduced and stabilized blood glucose levels, increased insulin levels, reduced insulin resistance (HOMA IR) and improved pancreatic β cell function (HOMA β).
  Oki Krisbianto , Mary Astuti and Yustinus Marsono
  Black rice (Oryza sativa L. indica) is rich in anthocyanin hence it could be used as functional food such as cereal for hyperglycemic patient. Black rice cereal supplemented with black soybean (Glycine max L. Merr) (RSC) was prepared as isocaloric feed for three groups of hyperglycemic rats. The first group (F0) was treated only with RSC, while the other two also receive 40 ppm (F4) and 80 ppm (F8) black rice bran anthocyanin extract (BRE). Non- hyperglycemic and hyperglycemic rats which were fed with standard feed were used as control (C) and hyperglycemic group (H) respectively. After 6 weeks experiments, blood glucose level, insulin resistance and MDA value were decreased in treatment groups, which were more significant in F4 and F8 than F0, while FRAP was increased. RSC and BRE alleviated inflammatory and steatosis in pancreas, liver and kidney as shown by the tissue preparation with Hematoxylin and Eosin (H &E) staining.
  Enny Purwati Nurlaili , Mary Astuti , Yustinus Marsono and Sri Naruki
  Rice is a leading staple food in Southeast Asia and it is typically milled before consumption. Black rice found in Indonesia is classified as Oryza sativa L. The color in the grain is caused by anthocyanin pigments that give the hulled rice a dark purple color. We found that extracts from black rice bran have high levels of iron and anthocyanins. The objective of this study was to evaluate the potential of an aqueous extract of black rice bran to prevent anemia and hypertriglyceridemia in vivo. Anemia and hypertriglyceridemia were induced in twenty-eight three-week old male albino Wistar rats (Rattus norvegicus); the rats were divided into a control (C) group or 3 treatment groups of bran (B), bran extract (E), or extraction residue (R). The results showed that differences among the groups based on feed consumption, Hemoglobin Regeneration Efficiency (HRE) and the erythrocyte morphology of rats were not significant. Black rice bran aqueous extract prevented anemia and hypertriglyceridemia by increasing the hemoglobin Hb level from 7.21 to 12.96 g/dl and by reducing triglycerides from 179.29 to 56.55 mg/dl.
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