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Articles by Martins Ekor
Total Records ( 3 ) for Martins Ekor
  Martins Ekor , Adesina O. Odewabi , Adewale G. Bakre , Kolawole S. Oritogun , Tomilola E. Ajayi and Oyemayowa V. Sanwo
  The antioxidant property of Sida acuta was recently demonstrated, in vitro. We proposed that this property could confer some protective benefit in alloxan model of diabetes mellitus in rats and compared the efficacy of the methanolic and ethanolic leaf extracts of the plant in this study. Diabetes was induced with alloxan monohydrate (150 mg kg-1, intraperitoneally). Diabetic rats were divided into six groups of 7 rats/group and treated with either ethanolic extract of Sida acuta (EESA), methanolic extract of Sida acuta (MESA, 200 and 400 mg kg-1) or glibenclamide (200 mg kg-1) orally for three days. Diabetic and normoglycaemic control received normal saline (10 mL kg-1). Animals were sacrificed by cervical dislocation 24 h after last administration. The EESA and MESA exhibited similar hypoglycaemic activity at 200 mg kg-1. The EESA (200 mg kg-1) significantly (p<0.01) lowered malondialdehyde and increased glutathione (GSH) and Uric Acid (UA) at 400 mg kg-1. The MESA increased GSH at both doses, produced mild decrease in malondialdehyde and increased UA at 200 mg kg-1 (p>0.05). Both extracts significantly reduced plasma total cholesterol (p<0.05) and triglyceride (p<0.001). The hypoglycaemic and hypolipidaemic effects of EESA and MESA were comparable to that of glibenclamide which did not affect antioxidant parameters. Both extracts significantly (p<0.05) raised haematocrit and Total White Blood Cell (TWBC). The MESA produced significant (p<0.05) increases in TWBC while EESA (400 mg kg-1) significantly (p<0.05) reversed the decrease in neutrophil count. Overall, EESA and MESA possess comparable hypoglycaemic and hypolipidaemic effects and show similar potential in attenuating alloxan-induced anaemic state with EESA exhibiting greater antioxidant activity.
  Daniels Konja , Isaac Tabiri Henneh , Samuel Badu-Nyarko , Samuel Addo Akwetey , Elvis Ofori Ameyaw and Martins Ekor
  Background and Objective: Sorghum bicolor (SB) and saltpeter (Sp) are food additives commonly used by food vendors of West African countries. Despite widespread use, there is still paucity of information on their safety, especially when used in combination. This present study investigated the sub-acute toxicity potential of aqueous extracts of SB and Sp when administered separately or in combination. Materials and Methods: About forty Sprague-Dawley rats of both sexes weighing 150-200 g were assigned into ten groups of four rats per group. SB or Sp was administered in three different doses (100, 300 or 1000 mg kg–1) to six different groups of rats. Three other groups received a combination of both SB and Sp at each of the dose levels while control rats received distilled water (10 mL kg–1). Extracts were administered once daily by gavage for 14 days after which rats were sacrificed by decapitation. Blood and some vital organs were obtained and processed for analyses. Significant differences were determined using a one-way ANOVA with Newman Keul’s post hoc test. Results: Sub-acute exposure to SB and Sp significantly (p<0.05) elevated activities of aspartate aminotransferase and alkaline phosphatase when administered separately or in combination. Blood glucose was significantly (p<0.05) elevated by SB and Sp combination at 300 and 1000 mg kg–1. Furthermore, exposure to SB, Sp or a combination of both induced tubular necrosis, dilatation, congestion, glomerular hypertrophy, infiltration by inflammatory cells or atrophy of glomerulus with increased capsular space. Similarly, exposure to separate doses of SB and Sp induced hepatic necrosis, congestion and dilatation of sinusoids and central vein and in addition, induced fatty changes when combined. Mild congestion of cardiac tissues, splenic necrosis and sinusoidal dilatation as well as oedema and infiltration of lung with inflammatory cells were also observed. Conclusion: Exposure to SB and Sp whether separately or in combination may be harmful to health and their continuous use as food additives should be of public health concern.
  Martins Ekor , Ayobami Opeyemi Akinrinde , Temitope Omolara Ogunyinka , Ernest Durugbo , Adesina Olalekan Odewabi , Oluwafemi Ezekiel Kale , Chiagoziem Anariochi Otuechere and Godwin Emerole
  Background and Objective: Interest in Moringa oleifera continues to increases rapidly because of the widely acclaimed effectiveness of this plant against diverse disease conditions in folk medicine. The present study investigated the therapeutic potential of aqueous and methanol leaf extracts of Moringa oleifera (AEMO and MEMO) against hepatotoxicity induced by cisplatin in rats. Materials and Methods: Different groups of cisplatin (7.5 mg kg–1, i.p.) intoxicated rats were treated separately with physiological saline (10 mL kg–1), AEMO (50 mg kg–1), AEMO (100 mg kg–1), MEMO (50 mg kg–1) or MEMO (100 mg kg–1). Separate groups of normal rats also received physiological saline (10 mL kg–1), AEMO (100 mg kg–1) or MEMO (100 mg kg–1). Treatments were administered orally for five consecutive days. Animals were sacrificed by cervical dislocation 24 h after last treatment (i.e. on the 6th day). Blood sample was collected by cardiac puncture and plasma separated for assessment of hepatic function. Liver was excised, homogenized and also used for other biochemical analysis. Data was analyzed by one-way analysis of variance (ANOVA) and least significant difference (LSD) for inter-group comparisons. Results: Cisplatin significantly elevated markers of liver function [aspartate aminotransferase (AST), alanine aminotransferase (ALT) activity, total cholesterol (TC) and triglyceride (TG)] and increased liver weight. This hepatic injury was associated with elevation in malondialdehyde together with diminished activity of antioxidant enzymes (catalase, glutathione-s-transferase and superoxide dismutase) and glutathione (GSH) concentration. TC, TG, catalase activity and liver weight improved significantly in the cisplatin intoxicated rats following treatment with AEMO. Although, MEMO (100 mg kg–1) increased AST activity and TC of normal rats, the extract (50 and 100 mg kg–1) significantly improved the lipid profile of cisplatin-treated rats. Similarly, glutathione-s-transferase, catalase, TC and liver weight of cisplatin intoxicated rats significantly improved after treatment with MEMO (50 and 100 mg kg–1). Conclusion: Overall, data show that AEMO and MEMO ameliorated some aspects of cisplatin-mediated hepatotoxicity suggesting potential therapeutic benefit against liver injury when employed in appropriate doses.
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