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Articles by Martina Restuati
Total Records ( 3 ) for Martina Restuati
  Martina Restuati and Diky Setya Diningrat
  Background and Objective: North Sumatera Indonesia has a rich heritage of knowledge on medicinal plants used for preventive and curative medicine Premna pubescens. Blume (Buasbuas) has been used to increase the body immunity and endurance. Centella asiatica (Pegagan) is used for medicinal purposes. This study is important to find out the antimicrobial capabilities of Premna pubescens (P. pubescens) and Centella asiatica (C. asiatica) methanol extracts. This study is expected to provide the scientific foundation for the development of plants that are traditionally believed to be efficacious drug. The aim of the study was to investigate in vitro antimicrobial activity of North Sumatera medicinal plants P. pubescens and C. asiatica against the main pathogens. Materials and Methods: The organic solvent plant extracts are tested on the various microorganisms including bacteria and fungi by using agar diffusion technique. The data was analyzed with ANOVA statistics by using SPSS software. Results: The length of the inhibition zone was measured in mm from the edge of the well to the inhibition zone. P. pubescens showed significant moderate activity against (14 mm) Pseudomonas marginalis and (21 mm) Streptococcus mutans with 100 mg mL–1 DMSO plant drug concentration. The results of lowest (MICs) values are at 66 and highest ones are at 152 mg mL–1 for P. pubescens meanwhile those of (MICs) values are 0-155 mg mL–1 for C. asiatica. Conclusion: In general, based on the result of this research, it can be said that P. pubescens and C. asiatica plants can be used as antibacterial and antifungal compounds.
  Mhd. Yusuf Nasution , Martina Restuati , Ahmad Shafwan S. Pulungan , Nanda Pratiwi and Diky Setya Diningrat
  Background and Objective: Centella asiatica belonging to family umbelliferae popularly known as pegagan, is very useful medicinal plant as an antimicrobial. However, the results of the study comparing anti-microbial activities of leaf and root of C. asiatica have not been properly documented. This paper reported on a research on the antimicrobial effect of leaf and root of C. asiatica ethanol, aqueous and chloroform extracts against representative micro-organism. Materials and Methods: The ethanol, aqueous and chloroform extracts of leaf and root of C. asiatica against six bacteria namely, Escherichia coli, Staphylococcus aureus, Staphylococcus albus, Streptococcus pyogenes, Psedomonas aeruginosa, Sreptococcus pneumonia and three fungi: Aspergillus niger, Aspergillus flavus, Microsporium boulardii and one yeast Candida albicans were determined using agar well diffusion and paper disk methods. Results: The results revealed that ethanol was the best extractive solvent for anti-microbial properties of leaf and root of C. asiatica followed in order by chloroform and aqueous. The ethanol extracts C. asiatica root gave the widest zone of inhibition against bacteria using agar well diffusion and the disc plate method. The growth of six bacterial isolates were inhibited by the three extracts except P. aeruginosa and S. pyogenes. Similarly, the growth of three test fungi were inhibited by ethanol and chloroform extracts while the aqueous extract was the least effective on the test fungi. The best antifungal activity was recorded in ethanol extract of C. asiatica root. The minimum inhibitory concentration (MIC) for the ethanol extract was between 5.0 and 20.0 mg mL1 for fungi. Conclusion: This study revealed that the C. asiatica root demonstrated strong inhibitory effect on the test organisms than C. asiatica leaf. The results therefore established a good support for the use of C. asiatica in traditional medicine.
  Martina Restuati , Ulfa Hidayat , Ahmad Shafwan S. Pulungan , Nanda Pratiwi and Diky Setya Diningrat
  Background and Objective: Premna pubescens blume popularly known as buasbuas belonging to the family Lamiaceae, wide-spread in the forests of Sumatra and Malaya peninsula. The preliminary screening of the ethanol extract of P. pubescens revealed the presence of alkaloids, steroids, flavonoids and phenolic. Previous studies revealed that there is no systematic study regarding the antimicrobial activity of leaf extracts of P. pubescens. The aim of this study was to assess the in vitro effect of leaf extracts of P. pubescens against Bacillus cereus and Escherichia coli causative agent of diarrheal diseases. Materials and Methods: Fresh leaves were procured from personal P. pubescens plant collections aged 5-7 years. Crude ethanol extract of leaves from P. pubescens were tested in vitro against B. cereus and E. coli at concentrations 10, 20, 30, 40 and 50 μg μL–1. Results: The B. cereus and E. coli showed concentration-dependent susceptibility towards the ethanol leaf extracts from P. pubescens. The degree of susceptibility varied depends on the concentrations, 50% concentration of P. pubescens leaf extracts showed the highest inhibition zone (12.5 and 13.6 mm diameter). Conclusion: Based on the current findings, it can be concluded that P. pubescens has antimicrobial activity which is as potent as standard antimicrobial drugs against B. cereus and E. coli. The antibacterial properties of P. pubescens leaves were not as effective as the commercial antibiotics chloramphenicol, enrofloxacin and penicillin. Nevertheless, future studies with higher extract concentrations, different method of extraction, properties from flowers, fruits, barks and roots extracts may be useful to evaluate the actual antibacterial performed to other pathogenic bacteria.
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