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Articles by Martin Kiendrebeogo
Total Records ( 4 ) for Martin Kiendrebeogo
  Wamtinga Richard Sawadogo , Aline Meda , Charles Euloge Lamien , Martin Kiendrebeogo , Innocent Pierre Guissou and Odile Germaine Nacoulma
  In this study the total phenolic and flavonoid content as well as the antioxidant activity of six Acanthaceae namely Blepharis lineariifolia PERS, Dicliptera verticillata (FORRSK.) C. CHRISTENS, Dyschoriste perrottetii (NEES) O. KTZE, Hygrophila auriculata (SCHUMACH.) HEINE, Lepidagathis anobrya NEES, Nelsonia canescens (LAM) SPRENG were evaluated. The total phenolic and flavonoid of their aqueous acetone extract were assessed by Folin-ciocalteu and AlCl3 method, respectively, whereas the antioxidant activities were determined by the DPPH method. Lepidagathis anobrya, Hygrophila auriculata and Nelsonia canescens which had the highest phenolic content, were found to possess the best antioxidant activities. The results suggest that these plants are good sources of antioxidants and support their use in cardiovascular and antiinflammatory diseases.
  Mindiediba Jean Bangou , Martin Kiendrebeogo , Moussa Compaore , Ahmed Yacouba Coulibaly , Nag-Tiero Roland Meda , Norma Almaraz Abarca , Boukare Zeba , Jeanne Millogo-Rasolodimby and Odile Germaine Nacoulma
  In the present study, 36 plant extracts, belonging to 6 families from Burkina Faso were used to evaluate their glutathione-S-transferase (GST), acetylcholinesterase (AChE), carboxylesterase (CES) and xanthine oxidase (XO) inhibitory activities and their phenolic, tannin and flavonoids contents by using spectrophotometrical methods. At 100 μg mL-1, Lippia chevalieri, Eclipta prostrata, Lantana camara and Indigofera pulchra extracts showed the best percentage of inhibition by regulating GST, AChE, CES and XO activities, respectively. The phytochemical investigations showed that all plant extracts were rich in biological compounds, namely phenolic, tannin and flavonoids. Particularly Cassia mimosoides extract presented the best phenolic, tannin and flavonoid contents. This result indicated that phenolic from Ceasalpiniaceae, flavonoids from Combretaceae and tannin from Verbenaceae contribute significantly to the inactivation of CES, AchE and GST, respectively. However, no significant correlation was found between polyphenolic compounds content and XO inhibitory activity. Present findings could partially justify the traditional uses of these plants in the treatment of mental disorders, gout, painful inflammations and cardiovascular diseases.
  Boukare Zeba , Martin Kiendrebeogo , Aline Lamien , Jean-Denis Docquier , Jacques Simpore and Odile Germaine Nacoulma
  Many clinical species of bacteria were isolated from biological samples such as urines, blood and wound in Saint Camille medical centre of Ouagadougou. Among the concerned species, the most important members were Escherichia coli and Klebsiella pneumoniae. These β-lactamases producing isolates were directly screened by PCR to identify the nature of the amplified genes responsible for penicillin destroying activity. Therefore specific TEM and SHV primers were used. The PCR products were sequenced. The sequencing results indicated that the parental forms blaTEM-1 and blaSHV-1 were the most common determinants of β-lactamase found, respectively in Escherichia species and Klebsiella pneumoniae. The bacterial susceptibility analysis by MICs measurement clearly correlated the presence of concerned β-lactamase determinants and their resistance patterns. This study is part of a set of investigations carried out by our laboratory to assess the β-lactamase incidence in the failure of β-lactam therapy. In particular, the purpose of this study was to determine the precise nature of β-lactamase supporting the low susceptibility of host bacteria towards penicillins.
  Mindiediba Jean Bangou , Martin Kiendrebeogo , Nag-Tiero Roland Meda , Ahmed Yacouba Coulibaly , Moussa Compaore , Boukare Zeba , Jeanne Millogo-Rasolodimby and Odile Germaine Nacoulma
  The aim of the present study was to evaluate some enzymes inhibitory effects of 11 plant species belonging to 9 families from Burkina Faso. Methanolic extracts were used for their Glutathione-s-transferase (GST), Acetylcholinesterase (AChE), Carboxylesterase (CES) and Xanthine Oxidase (XO) inhibitory activities at final concentration of 100 μg mL-1. The total phenolics, flavonoids and tannins were also determined spectrophotometrically using Folin-Ciocalteu, AlCl3 and ammonium citrate iron reagents, respectively. Among the 11 species tested, the best inhibitory percentages were found with Euphorbia hirta, Sclerocarya birrea and Scoparia dulcis (inhibition>40%) followed by Annona senegalensis, Annona squamosa, Polygala arenaria and Ceratotheca sesamoides (inhibition>25%). The best total phenolic and tannin contents were found with S. birrea with 56.10 mg GAE/100 mg extract and 47.75 mg TAE/100 mg extract, respectively. E hirta presented the higher total flavonoids (9.96 mg QE/100 mg extract). It's was found that Sclerocarya birrea has inhibited all enzymes at more than 30% and this activity is correlated to total tannins contents. Contrary to S. birrea, the enzymatic activities of E. hirta and S. dulcis are correlated to total flavonoids contents. Present findings suggest that the methanolic extracts of those plant species are potential inhibitors of GST, AChE, CES and XO and confirm their traditional uses in the treatment of mental disorders, gout, painful inflammations and cardiovascular diseases.
 
 
 
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