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Articles by Mariano Malaguarnera
Total Records ( 1 ) for Mariano Malaguarnera
  Cecilia Zuppi , Jacques Simpore , Bruno Zappacosta , Cinzia Carrozza , Mariano Malaguarnera and Salvatore Musumeci
  Biological aging implies a progressive decrease of endocrine and metabolic resources, which correspond to a reduction of working activity and caloric intake. The aim of this study was to measure DHEA-S and IGF-1 and products of methionine metabolism in 76 postmenopausal African women (50 to 100 years of age) compared to 22 adult African fertile women (30 to 45 years of age). Determination of plasma DHEA-S in elderly women gave a markedly low mean concentration and the same was observed for plasma IGF-1 (450.1±263.2 and 64.2±38.1 ng mL-1, respectively). The correlation between DHEA-S and IGF-1 was significantly positive only in 71-100 years women (r = 0.44, p<0.05). There was a significant decrease of plasma glutathione in all elderly women (3.5±0.4 μMol L-1), while the plasma homocysteine (Hcy) was markedly elevated (18.7±0.5 μMol L-1), whilst that of folic acid, Vit B12 and Vit B 6 levels were found in the normal range. A significant positive correlation between DHEA-S and plasma glutathione levels (r = 0.56, p<0.025) was found only in the 50-60 old years women group, while the correlation between IGF-1 and plasma glutathione was negative but not significant (r = -0.36, p = NS) in the same age group. In this study a low level of IGF-1 and DHEA-S in old humans is firstly considered as consequence of hypo-caloric alimentation, moderate physical activity and absence of psychophysics stress. Moreover a positive correlation between IGF-1 and DHEA-S in oldest age populations, ranging from 71 to 100 years, suggests that endocrine and metabolic systems must be maintained in a lower equilibrium to compensate the physiological reduction of the oxidant/antioxidant balance (low level of plasma glutathione).
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