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Articles by Maria C. Castillo-Hernandez
Total Records ( 2 ) for Maria C. Castillo-Hernandez
  Maria C. Castillo-Hernandez , Eleazar Lara-Padilla , Alexandre Kormanovski , Jorge G. Perez-Tunon , Emilio M. Lopez-Calderon and Gustavo Guevara-Balcazar
  Tricyclic antidepressants are responsible for the majority of cases of intoxication due to psychoactive medications. Such intoxication results in an alteration of cardiovascular function. Sodium bicarbonate (HCO3) is the current treatment of choice, although, we propose Hyperbaric Oxygenation (HBO) therapy as an alternative treatment, since it is known to be an effective adjuvant therapy in the treatment of cardiovascular disease. However, the use and utility of this therapy has not been fully clarified. To evaluate hyperbaric oxygenation therapy as a collaborating agent in the treatment of amitriptyline intoxication, allowing recovery in a lesser period of time of the cardiovascular parameters under study, as compared to the sodium bicarbonate treatment. Male Wistar rats were intoxicated with amitriptyline and hyperbaric oxygen therapy or sodium bicarbonate were administered as a treatment. Blood pressure measures were taken and an electrocardiogram was performed to determine the heartbeat and the length of the QRS interval. After amitriptyline intoxication and first treatment with either HCO3 or HBO, heartbeat returned to normal and the length of the QRS segment was shortened. The latter parameter returned to normal after the second treatment with either SB or HBO. Whereas, HBO therapy normalized blood pressure after the first treatment, this result was found only after the second treatment with SB. The HBO therapy proved better than SB treatment for improving blood pressure.
  Mayre Ivonne Bautista Albiter , Gustavo Guevara-Balcazar , Israel Ramirez-Sanchez , Alexandre Kormanovski , Maria E. Aguilar-Najera , Jesus Nolasco and Maria C. Castillo-Hernandez
  Background and Objective: Phosphide exposure is one of the most lethal types of poisoning because there is no specific antidote; therefore, the objectives of this study were to analyze the levels of oxidative and mitochondrial damage caused by poisoning and to determine whether gastric lavage with either olive oil or bicarbonate and hyperbaric oxidation therapy improves the recovery from this type of poisoning. Methodology: Female Wistar rats (300±30 g) were assigned to 1 of 5 groups. In groups with poisoned rats, 27 mg of aluminum phosphide was administered, after which some of the rats received treatment via gastric lavage (olive oil, 10 mg kg–1 or sodium bicarbonate, 1 mEq kg–1) and/or hyperbaric oxygenation therapy. The enzymatic activities of citrate synthase and catalase were measured in cardiac, liver and lung tissue and lactate levels were measured in plasma by spectrophotometry. Results: After phosphide administration, the results showed a reduction in the enzymatic activities of catalase, citrate synthase and lactate; however, after combining the gastric lavage of bicarbonate with hyperbaric oxygenation, the catalase and citrate synthase activities increased and the lactate activity returned to normal levels. Conclusion: It is concluded that combining hyperbaric oxygenation with gastric lavage exerted a protective effect by reducing the cellular damage and normalizing the enzymatic activities of catalase and lactate.
 
 
 
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