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Articles by Margaret T. Agyei-Frempong
Total Records ( 2 ) for Margaret T. Agyei-Frempong
  Margaret T. Agyei-Frempong , Samuel A. Sakyi and Robert E. Quansah
  The need for a specific standard test for Rheumatoid Arthritis (RA) cannot be overemphasized. In many instances, either the clinical diagnosis or the disease classification according to America College of Rheumatology (ACR) criteria is used as the basis for defining whether the patient has RA or not. However, predicting the clinical outcome of RA in a patient is more important for therapeutic decision making than predicting whether an arthritis syndrome will ever satisfy a set of classification criteria. The aim of this study was to compare anti-Cyclic Citrullinated Peptide test with those of Rheumatoid Factor (RF) and its isotypes RF-IgA and RF-IgM for early and differential diagnosis of RA. In a cross-sectional study, the concentrations of RF and its isotypes RF-IgA and RF-IgM and anti-Cyclic Citrullinated Peptide were determined in 102 classified and unclassified RA patients and 50 citrullinated peptide antibodies, rheumatoid factor., Rheumatoid factor-immunoglobulin M and A (RF-IgM, RF-IgA) (51.75%). The high specificity of anti-CCP combined with the high sensitivity of RF-IgM infers that a combination of anti-CCP and RF-IgM is a good predictor for early diagnosis and course of RA.
  Samuel A. Sakyi , Margaret T. Agyei-Frempong and Robert E. Quansah
  HLA-B27 is a genetic predisposition marker for the development of Ankylosing Spondylitis (AS). AS is uncommon in West-Africa, but due to environmental and lifestyle changes, its prevalence is said to be increasing. This study sought to determine the baseline prevalence of HLA-B27 among Ghanaians presenting with AS, find out their disease activity, clinical presentation, presence of extra-articular manifestations, inflammation and dyslipidemia. In a cross-sectional study, 65 AS subjects were recruited from the orthopaedic departments of two leading Teaching Hospitals and a private laboratory, medilab diagnostics with centres across the country. Fifty healthy blood donors were also recruited as control group. HLA-B27, BASDAI score, Lipid profile, TNF-α and ESR levels were estimated among them. Statistical comparisons were analyzed using the one way ANOVA followed by Bonferroni’s Multiple Comparison test. There were four HLA-B27 positives representing 4.6%, the mean BASDAI score was 44.7/100. 48 AS patients had Sacroiliitis in their X-ray reports. None had a family history or any extra-articular manifestations. AS subjects had higher (p<0.001) levels of total cholesterol and triglycerides compared to the controls. The HDL level for the patients was significantly lower (p<0.001), as compared to the control. The LDL level indicates a higher (p<0.001) value as compared to the controls. TNF-α level was 13.11±0.50 pg mL-1 compared to 5.70±0.48 pg mL-1 of control whiles the ESR was 34.64±1.87 mm h-1 as compared to 9.23±0.91 mm h-1 of controls. AS patients had moderate disease activity with no extra articular manifestation and a prevalence of 4.6%. Dyslipidemia was prominent and that inflammation plays a pivotal role in the development of atherosclerosis.
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