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Articles by Manu Chaudhary
Total Records ( 2 ) for Manu Chaudhary
  Masoom Raza Siddiqui , Abu Tariq , Manu Chaudhary , K. Dinesh Reddy , Prithvi Singh Negi , Jitendra Yadav , Nitya Srivastava , Sanjay Mohan Shrivastava and Rajkumar Singh
  Problem statement: To develop a sensitive method to determine simultaneously ceftizidime and sulbactam in spiked plasma and combined formulation. Approach: In this study an isocratic High performance liquid chromatographic method with UV detection at 230 nm was described for simultaneous determination of Ceftazidime and sulbactam sodium in plasma and combined dosage form. Chromatographic separation of two drugs was achieved on a Hypersil ODS C-18 column using a mobile phase consisting of a binary mixture of acetonitrile and tetrabutyl ammonium hydroxide adjusted to pH 5.0 with orthophosphoric acid in ratio 25:75. Results: The developed performance liquid chromatographic method offers symmetric peak shape, good resolution and reasonable retention time for both drugs. Linearity, accuracy and precision were found to be acceptable over the concentration range of 125-625 ppm for Ceftazidime and 62.5-312.5 ppm for sulbactam sodium. Conclusion: The results showed that this method could be well used for the simultaneous estimation of Ceftazidime and Sulbactam in plasma and combined formulation.
  Arvind Soni , Manu Chaudhary and Vivek Kumar Dwivedi
  The aim of the present study was to evaluated the effect of the VRP 1020 in reconstitution with fixed dose combination of ceftriaxone-vancomycin (Vancoplus). The mice were fed standard pelleted diet and water ad libitum. The test room was air conditioned with temperature 23±20°C, humidity 65±5% and with artificial fluorescent light (10-14 h) of light and dark, respectively. Thirty Mus musculus mice (weighing 30±5 g) were divided into 5 groups containing 6 mice in each group. Group I: control (normal saline), group II: ceftriaxone (28.57 mg kg-1 body weight/day) group III: vancomycin (14.2 mg kg-1 body weight/day), group IV: ceftriaxone-vancomycin (42.8 mg kg-1 body weight/day) and group V: ceftriaxone-vancomycin+VRP 1020 (42.8 mg kg-1 body weight/day). Present finding showed that activities of antioxidant enzymes (superoxide dismutase and catalase) and pyridoxal-5-phosphate level (biologically most active co-enzyme of vitamin B6) were significantly increased along with decreased in lipid peroxidation (malonaldialdehyde) level in vancoplus treated group as compared to ceftriaxone and vancomycin alone and combination of ceftriaxone-vancomycin treated group. Similarly, the levels of extracellular antioxidant (creatinine and uric acid) were found to be significant lowered in vancoplus treated group when compared to ceftriaxone, vancomycin and ceftriaxone-vancomycin treated group. These results indicated that reconstitution of VRP 1020 with fixed dose combination of ceftriaxone-vancomycin protects against ceftriaxone and vancomycin induced nephrotoxicity that improved the activities of free radical scavenging enzymes.
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