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The antioxidant activity of soybean crude extract against
induced oxidative damage has been achieved through quails Coturnix
coturnix treatment with various copper sulphate concentrations alone
or with a protective dose of soybean crude extract. Several parameters
of oxidative stress together with liver and kidney function tests in serum
and liver tissue homogenate were studied. Hematologic indices and liver
copper content were determined. Obtained data showed a significant increase
in the serum activity of aspartate transaminase (AST), alanine transaminase
(ALT) and malondialdehyde (MDA) content under a sever oxidative damage
induced by highly copper sulphate treatments, also the total cholesterol,
Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) and uric
acid in addition to the antioxidant defense enzymes have been affected
by copper toxicity in serum and liver homogenate. The results of the present
investigation represented the protective activity of soybean phenolic
compounds against the induced oxidative damage caused by copper toxicity.
The protective antioxidant activity of soybean extract may be achieved
through the inhibition of lipid peroxidation and membrane damage promoted
by copper sulphate toxicity.
