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Articles by Manorma Sharma
Total Records ( 2 ) for Manorma Sharma
  Manorma Sharma , Archana Sharma , Ashwani Kumar and Saikat Kumar Basu
  Planttissue culturesare exposed to stresses and stress combinations that they may not have encountered in nature in their long evolution. It is a remarkable reflection on the plasticity of the plant genome that it can decipher and respond to novel in vitro stresses. Today various tissue culture techniques are used to enhance yield of secondary metabolites by trigger stress response like using Elicitors, Precursors and Biotransformation, change in environmental conditions, change in medium constituents etc. The focus of the study is to enhancement of secondary metabolites by triggerthe expression of stress marker genes. This would help in conservation of this species and provide pharmaceutical component in less time and cheap cost.
  Manorma Sharma , Archana Sharma and Ashwani Kumar
  The aim of present study was to evaluate immunomodulatory potential of ethanolic extract of Asparagus racemosus Wild. and Chlorophytum arundinaceum Baker. in comparison to established immunosuppressant Cedrus deodara wood oil (100 mg kg-1 b.wt.) in mice. The assessment of immunomodulatory activity on specific and nonspecific immunity was studied by Delayed Type Hypersensitivity (DTH) and neutrophil adhesion test respectively. Through Neutrophil adhesion test maximum sensitivity was observed in in vivo extract of C. arundinaceum while percent inhibition was maximum in in vitro extract of A. racemosus. In vivo Chlorophytum arundinaceum extract at 300 mg kg-1 dose statistically significantly inhibit the adhesion of neutrophils to nylon fiber. However, in vivo A. racemosus at the dose of 300 mg kg-1 was found to significantly decreased rat paw edema as compared to control, in vivo C. arundinaceumand in vitro A. racemosus extract. The present study has shown the immunomodulatory activity of both plants by potentiating humoral as well as cellular immunity.
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