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Articles by Manizheh Karami
Total Records ( 1 ) for Manizheh Karami
  Masoomeh Pirouzi , Manizheh Karami and Mohammad-Reza Jalali Nadoushan
  It has been shown that naloxone induces place aversion in the conditioning task. We examined the involvement of Nitric Oxide (NO) in naloxone- induced place aversion. The experiment was conducted in male Wistar rats (weighing 200-250 g) using an unbiased conditioning program. Control group solely received saline (1 mL kg-1, i.p.) throughout the procedure. The experimental animals were injected naloxone (0.1-0.4 mg kg-1, i.p.) once per day during the phase of conditioning. L-Arginine (0.003-3 μg rat-1), the precursor of NO, was microinjected intra-CA1 prior to testing of naloxone response. A selective inhibitor of neuronal NO synthase (nNOS), L-NAME (0.03-3 μg rat-1), was pre-microinjected in testing day. Naloxone induced a significant place aversion in the experimental animals. The main narcotic drug also caused an increase in Wet Dog Shaking (WDS). The drug use, however, attenuated the compartment entering. The place aversion induced of naloxone was highly potentiated due to microinjection of L-arginine intra-CA1. This injection also increased the compartment entering and the rearing but not the WDS. The potentiated aversion response induced of L-arginine pre-testing was blocked by pre-microinjection of L-NAME. The NOS inhibitor L-NAME moreover restored the WDS induced by naloxone. The molecule NO in the CA1 likely interacts with naloxone in induction of place aversion.
 
 
 
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