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Articles by Mamunur Rashid
Total Records ( 6 ) for Mamunur Rashid
  Sharif Mohammad Shaheen , Md. Nazir Hossen , Kazi Mehedul Islam , Maruf Ahmed , Md. Shah Amran and Mamunur Rashid
  In order to evaluate the feasible application of bio-adhesive polymers like HPMC-15 cps and 50 cps; gelatin; Na-CMC and xantham gum in sustained release dosage form (SRDF), tablets containing various amount of bio-adhesive polymers with a model drug like anhydrous Theophylline sodium glycinate were prepared by compression in a hydraulic press (Perkin Elmer) compression machine using 5 ton pressure. The release characteristics of Theophylline (TH) from sustained release tablets were analyzed in triplicate using a thermal shaker (Memmert) with a shaking speed of 50 rpm at 37±0.5°C in 250 mL of simulated gastric fluid without enzyme for 8 h. At the end of 8 h of dissolution it was found that 61.60% (for 300 mg HPMC-15 cps) and 42.92% (for 500 mg HPMC-15 cps) of TH was released from HPMC-15 cps based tablets, respectively. When HPMC-15cps was increased to 50 cps, 52.12 and 59.66% of TH was released, respectively. Both concentration and viscosity depended sustained release of TH was found. 74.13 and 94.15% of TH was released from Gelatin based SR tablets of the same concentrations, respectively. Gelatin also showed the same concentration effects i.e. release was reduced with an increase in concentration of polymer. 52.40 and 50.95% of TH was released from Na-CMC based SR tablets of the same concentrations, respectively and that of 76.96 and 78.26% of TH from xanthan gum based tablets. It means that there was no remarkable concentration effect of these two polymers on the TH release. In all cases there was almost zero order release fashion. Bio-adhesive polymers like HPMC and gelatin might be successfully applicable in SRDF rather than Na-CMC and xanthan gum studied here.
  Mst. Sabina Easmin , M. Shamim Hossain , Chanmiya Sheikh , M.Saidul Islam , M. Anwarul Islam and Mamunur Rashid
  The aim of the present study was to investigate the antimicrobial and cytotoxic activities of four newly synthesized iron (III) based complexes [Fe(Suc)2(Phenylamine)2, F1], [Fe(Suc)2(Serine)2, F2], [Fe(Suc)2(Leucine)2, F3] and [Fe(Suc)2(Cystein)2, F4]. The complexes F1, F2, F3, F4 showed modest antibacterial and antifungal activities at the concentration of 200 μg disc-1 and gave MIC values between 16-64 μg ml-1 against the tested bacteria. Brine shrimp lethality bioassay was carried out for cytotoxicity measurements of the complexes and the LC50 values were calculated after probit transformation of the resulting mortality data. All the complexes showed lower cytotoxic properties compared with the reference standard gallic acid (4.53 μg ml-1) and bleomycin (0.41 μg ml-1).
  Md. Belal Hossain , Mamunur Rashid and A.K.M. Motahar Hossain
  The aim of the present study was to investigate the release of ibuprofen (IB) from matrix tablets using a combination of water insoluble waxy materials with hydrophilic polymers. The waxy materials were added as additives to the hydrophilic polymer, hydroxy propyl methyl cellulose (HPMC). Bees wax (BW), cetyl alcohol (CA) and stearic acid (SA) used as waxy materials that were added in increasing amount (up to 30% of total weight of tablet) to the HPMC based sustained release (SR) matrix tablets. The results showed that the matrix tablets using all the additives released the drug by zero order mechanism. Addition of waxy materials into the matrix significantly decreased the rate of drug release due to the reduction in penetration of the dissolution fluid. From the release profiles excellent correlation was found between the concentration of waxy materials and ibuprofen release rate.
  Sharif Md. Shaheen , Mamunur Rashid , Md. Anwar ul Islam and Reza Ul Jalil
  Egg albumin (EA) matrix tablets containing theophylline (TH) were prepared by direct compression using 13 mm die and punch and a hydraulic press (3 ton compressor) after simple dry mixing of these two ingredients. Chemical denaturation of EA using both glutaraldehyde and formaldehyde as cross linking agents showed a remarkable decrease in TH release rate from matrix tablets when compared with untreated and heat denatured TH matrix tablets. The release rate was further reduced when mutual chemical and heating denaturations were applied. In all cases release mechanism was square root of time dependent indicating diffusion type release. It was found that heating for 1 h at only 65°C was enough to produce the release retardation effect, whereas, heating beyond 65°C (up to 105°C) had no significant effect on the release rate. Heat denatured tablets also showed a Higuchian release pattern. The release rate of heat denatured (at 105°C for 1 h) matrices were slightly decreased than the unheated tablets. However the duration   of heating (20 to 100 min) had no significant effect on the release rate.
  Md. Belal Hossain , Mamunur Rashid and A.K.M. Motahar Hossain
  The effects of various percentages (0, 3, 6, 9, 12 and 15%) of Glycerol Mono Stearate (GMS), Stearic Acid (SA) and Cetyl Alcohol (CA) on the release rate of Ibuprofen (IB) from polyethylene glycol-4000 (PEG)-based suppositories were studied. Ibuprofen suppositories of PEG-4000 base were prepared using GMS, SA and CA separately in different formulations by fusion method. Dissolution studies showed a rapid release of the drug during 30-60 min from the PEG-based suppositories of IB and almost 75% of the drug was released within this period. But the incorporation of waxy additives GMS, CA and SA in the formulation reduces this rapid release rate of the drug. Three percent GMS containing PEG-based suppositories liberated about 70.0% of the drug within 6 h whereas maximum 45.0% and 51.0% of drug were liberated from 3% SA and 3% CA containing PEG-based suppositories, respectively, within the same time. The drug release reducing capabilities of the waxy additives were found to be in the following order SA>CA>GMS. Utilizing this capability of the additives, sustained release suppositories of ibuprofen could be formulated.
  Chanmyia Sheikh , M. Shamim Hossain , Mst. Sabina Easmin , M. Saidul Islam , M. Aslam Hossain and Mamunur Rashid
  The aim of the present study was to investigate the biocidal activity of seven new chromium based coordination complexes [Cr(Pht)2 (Glycine)2, S1], [Cr(Pht)2 (Leucine)2, S2], [Cr(Pht)2 (Cystein)2, S3], [Cr(Pht)2 (Serine)2, S4], [Cr(Suc)2 (Leucine)2, S5], [Cr(Suc)2 (Cystein)2, S6] and [Cr(Suc)2 (Serine)2, S7] against Gram-positive and -negative bacteria, fungi and brine shrimp nauplii. The complexes S1, S3, S4, S6 showed good antibacterial activity at the concentration of 200 μg disc-1 and gave MIC values between 16-64 μg ml-1 against the tested bacteria. The complexes gave comparatively better antibacterial activity against the Gram-negatives. S2 did not show any remarkable antifungal activity but others showed good activity. The brine shrimp were hatched in artificial sea water and exposed to the complexes to determine mortality rate. LC50 values were calculated after probit transformation of the resulting data. All the complexes showed better cytotoxic effect but among them S1 and S3 having LC50 values of 3.31 and 3.63 μg ml-1 showed potent cytotoxic activity when compared with the reference standard Gallic acid whose LC50 values was 4.53 μg ml-1.
 
 
 
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