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Articles by Majid A. Ganaie
Total Records ( 3 ) for Majid A. Ganaie
  Hasan S. Yusufoglu , Gamal A. Soliman , Rehab F. Abdel-Rahman , Maged Saad Abdel-Kader , Majid A. Ganaie , Erdal Bedir , Sura Baykan and Bintug Ozturk
  In the present study, DPPH radical scavenging assay and ferric-reducing antioxidant assay were used to evaluate in vitro antioxidant potential of the methanol extract of Ferula duranii (F. duranii). The antihyperglycemic and antihyperlipidemic activities of F. duranii extract were evaluated in streptozotocin (STZ)-induced diabetic rats. F. duranii showed considerable antioxidant potential in the DPPH radical scavenging assay and minimum reducing power in ferric-reducing antioxidant power assay. A meaningful reduction in the concentrations of Fasting Blood Glucose (FBG), glycosylated hemoglobin (Hb A1c), triglycerides (TG), Total Cholesterol (TC) and Low Density Lipoprotein (LDL-C) in plasma and an elevation in the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) in hepatic and pancreas homogenates were observed in diabetic animals medicated with F. duranii extract in comparison with diabetic control rats. The level of insulin raised significantly in plasma of diabetic groups received F. duranii in respect to diabetic control one. Levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, total protein and High Density Lipoprotein (HDL-C) in plasma and malondialdehyde (MDA) in liver and pancreas homogenates were recovered significantly in F. duranii-medicated diabetic rats in comparison with diabetic controls. The present data suggest that F. duranii has both antidiabetic and antihyperlipidemic effects.
  Najeeb Ur Rehman , Mohd Nazam Ansari , Majid A. Ganaie , Hassan A. Madkhali , Abdulaziz S. Saeedan , Faisal Imam and Abubaker M. Hamad
  Background and Objective: Oxidative injury is reflected as an early sign of cadmium (Cd) toxicity and has been linked with hepatotoxicity. The present study was conducted to investigate the ameliorative effect of roflumilast (ROF), a phosphodiesterase-4 inhibitor against Cd-induced hepatotoxicity in Wistar albino rats. Materials and Methods: Twenty four rats were assigned to four groups (n = 6). Group 1 served as normal control and the second group was administered with cadmium chloride (3 mg kg1, i.p.) for seven consecutive days. Third and fourth group rats were treated with Cd with concomitant administration of ROF at doses of 0.5 and 1.5 mg kg1 (p.o.), respectively for 7 days. At the end of the study, blood samples were collected for the estimation of liver functions biomarker (AST and ALT). Followed by blood collection, all rats were sacrificed and hepatic tissues isolated for assessment of oxidative stress markers (MDA, GSH, SOD and CAT) and histopathological studies. Results: The treatment of rats with Cd results in increased serum AST and ALT levels and lipid peroxidation, depleted hepatic GSH content and inhibited activities of SOD and CAT significantly compared to the normal control group. The histological assessment showed vacuolar degeneration of liver cells with focal necrosis in Cd treated rats. ROF administration at both doses preserved the biochemical and histological changes in dose-dependent manner caused by Cd toxicity to near-normal levels. Conclusion: The present study concludes that ROF might be acting as an antioxidant and protect the liver from Cd-induced oxidative stress.
  Hasan S. Yusufoglu , Gamal A. Soliman , Rehab F. Abdel- Rahman , Maged Saad Abdel-Kader , Majid A. Ganaie , Erdal Bedir , Sura Baykan Erel and Bintug Ozturk
  The present study was carried to explore the potential antihyperglycemic and antihyperlipidemic activity of Ferula assa-foetida L. and Ferula tenuissima Hub-Mor & Pesmen extracts in streptozotocin (STZ) induced diabetic rats. Furthermore, phytochemical screening, in vitro antioxidant activity and acute toxicity study of both plants were performed. Both extracts showed considerable antioxidant potential in vitro. In diabetic rats, F. assa-foetida (200 and 400 mg kg–1) and F. tenuissima (400 mg kg–1) showed significant elevation in plasma insulin level, total hemoglobin (Hb) and decrease in Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels. Significant elevations in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and level of reduced glutathione (GSH) in liver and pancreas homogenates were observed in diabetic animals following F. assa-foetida (200 and 400 mg kg–1) and F. tenuissima (400 mg kg–1) treatments. The antihyperlipidemic effect of F. assa-foetida extract was demonstrated by a significant reduction in plasma triglycerides (TG), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C) and the increase of High Density Lipoprotein Cholesterol (HDL-C). Plasma activities of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and levels of Total Protein (TP) and bilirubin (BIL) in diabetic rats were recovered significantly after F. assa-foetida and F. tenuissima treatment in comparison with diabetic controls. The present data suggest that F. assa-foetida have both antihyperglycemic and antihyperlipidemic effects with enhancement of insulin-secreting activity.
 
 
 
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