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Articles by Mahnaz Khanavi
Total Records ( 7 ) for Mahnaz Khanavi
  Mahnaz Khanavi , Marzieh Taheri , Afsaneh Rajabi , Saeed Fallah-Bonekohal , Maryam Baeeri , Azadeh Mohammadirad , Gholamreza Amin and Mohammad Abdollahi
  The aqueous, dichloromethane, ethyl acetate and methanol extracts of dried aerial fruiting parts of Centaurea bruguierana ssp. belangerana were investigated for hypoglycemic mechanism in diabetic rats. Diabetes was induced by intravenous administration of streptozotocin-alloxan. The methanol and ethyl acetate extracts were administered in a single effective dose of 200 mg kg-1 and dichloromethane and aqueous extracts were administered in a single effective dose of 400 mg kg-1. Blood glucose was determined every 1 h until 3 h post administration of the extracts. In the second experiment, the liver was surgically removed 3 h post treatment of diabetic rats with various extracts, homogenized and used for measurement of key enzymes of glycogenolysis (glycogen phosphorylase, GP) and gluconeogenesis (phosphoenolpyruvate carboxykinase, PEPCK). Treatment by dichloromethane, ethyl acetate, methanol and aqueous extracts and the glibenclamide, reduced blood glucose to 41.7, 55.0, 45.7, 29.5 and 34.5%, respectively. The aqueous extract showed the best effect in reduction of hepatic PEPCK activity (84.0%) and increased hepatic GP activity (134.5%), while glibenclamide showed 62.5 and 133.0% activity, respectively. None of the extracts affected blood insulin. Presence of sugar in dried aqueous extract could suppress the hypoglycemic effect during the first hour of the experiment. After 1 h, the hepatic mechanism overwhelmed and thus lowering effect in blood glucose appeared. The conclusion is that C. bruguierana ssp. belangerana is able to lower blood glucose via stimulation of hepatic glycogenolysis and inhibition of gluconeogenesis.
  Mahnaz Khanavi , Mohammad-reza Delnavazi , Vahid Nikoui , Sattar Ostadhadi and Azam Bakhtiarian
  In this research, hydroalcoholic extract obtained from the aerial parts of Marrubium parviflorum (Lamiaceae) was subjected to evaluation of analgesic effects using formalin test at the doses of 50, 100 and 200 mg kg-1 in mice. Duration of licking and biting time (min) of the injected paw was recorded at 5 min intervals for 40 min after formalin injection as a pain index. Results of study showed that the dose of 100 mg kg-1 of the extract decreased duration of licking and biting time between 15 and 40 min, but this effect was not statistically significant (p>0.05), while the dose of 200 mg kg-1 of extract showed significant analgesic effects (p<0.05) in the chronic phase (15-40 min) of formalin induced pain that this analgesic effect was equal to morphine. Considering that chronic phase of formalin induced pain is a secondary response to formalin induced inflammation, results of study introduce the M. parviflorum as a valuable analgesic herbal medicine that can be used in treatment of inflammatory painful disease. It is possible to assume that phytochemical contents of M. parviflorum reduce inflammatory pain by inhibiting the formation of inflammatory mediators such as prostaglandins followed by inhibiting COX-II enzyme.
  Mahmoud Biglar , Mohammad Reza Shams Ardekani , Mahnaz Khanavi , Abbas Shafiee , Abdolhossein Rustaiyan , Fahimeh Salimpour and Fatemeh Farjadmand
  The oils obtained by hydrodistillation and steam distillation of the aerial part of Stachys pubescence Ten. was analyzed by GC and GC/MS. Water distilled essential oil of the aerial part of S. pubescence, was rich in fatty acids like hexadecanoic acid and linoleic acid and also benzaldehyde and spathulenol whereas the steam distilled oil of the plant contained hexadecanoic acid, spathulenol and eugenol. Both of oils were rich in fatty acids (36.6 and 27.9%, respectively). Moreover, the content of oxygenated mono and sesquiterpenss were defined higher in steam distilled oil than hydrodistiled oil (24.5, 17.2 and 6.1, 15.5%, respectively). In conclusion it seems that oxygenated terpenoids were trended to steam distillation method more than hydrodistilation, respectively.
  Mahnaz Khanavi , Shabnam Pourmoslemi , Behnaz Farahanikia , Abbas Hadjiakhoondi and Seyed Nasser Ostad
  Vinca minor L. (Apocynaceae) is a medicinal plant that has long been used to treat cerebral and memory disorders in European folk medicine. Furthermore, it contains more than 50 alkaloids, some of them having bisindole structure such as the antineoplastic alkaloids present in Catharanthus roseus (L.) G. Don (Apocynaceae). In this study, the plant’s alkaloid extract was divided into three fractions and the cytotoxic effects on cell proliferation of HT-29, Caco-2, T47D, and NIH/3T3 cell lines were examined. All alkaloid fractions showed a dose-dependent cytotoxic effect on the cell lines. IC50 values confirmed that the growth and proliferation of NIH/3T3 cells were less affected in comparison to other cell lines.
  Samineh Jafari , Arman Moradi , Ali Salaritabar , Abbas Hadjiakhoondi and Mahnaz Khanavi
  The crude extract and 4 fractions of aerial parts of cultivated motherwort (Leonurus cardiaca L.) were investigated for their total phenolic and flavonoid contents and antioxidant activities. The phenolic and flavonoid contents were determined using Folin-Ciocalteu assay and proposed assay of pharmacopeia where as antioxidant activity of samples were measured by 2 tests: DPPH and FRAP assays. Buthanolic fraction showed the highest antioxidant activity with the FRAP value of 1.735±0.07 μmol g-1 and DPPH inhibitory percentage of 57.76% μg mL-1 as well as the greatest phenolics content (48.37±3.76 mg of gallic acid equivalents g-1). The highest total flavonoid content was revealed in methanolic-aqueous fraction (50.21± 0.65 mg of hyperoside equivalents g-1). There was a direct correlation between total phenol and antioxidant activities which could introduce phenols as the main antioxidants of L. cardiaca L. extracts.
  Mahnaz Khanavi , Mana Moshteh , Azadeh Manayi , Mohamad Reza Shams Ardekani , Mahdi Vazirian , Yousef Ajani and Seyed Nasser Ostad
  The aerial parts of Lythrum salicaria L. from Lahijan in Gillan province have been collected in June 2009. Total extract were obtained by MeOH/H2O (80/20) and then partitioned between CHCl3, EtOAc and MeOH. These fractions and total extract have been investigated for in vitro cytotoxic activity against colon carcinoma (HT-29), lukemia (K562), breast ductal carcinoma (T47D) and Swiss mouse embryo fibroblast (NIH 3T3) cell lines by MTT assay (3-(4,5-di methyl thiazol-2-yl)-2,5-di phenyltetrazolium bromide). At each cell line doses of 50, 100, 200, 400 and 800 μg mL-1 in 1% (v/v) DMSO of all samples were tested. Ethyl acetate fraction against proliferation of T47D cell line has been represented high cytotoxic activity (IC50<70). Chloroform fraction and total extract against proliferation of T47D cell line and chloroform fraction toward K562 cell line and total extract against HT-29 cell line have been demonstrated slightly cytotoxic activity (IC50<200). The other fractions have been demonstrated no effective cytotoxic activity. IC50 values confirmed that the growth and proliferation of T47D cells were most affected by ethyl acetate fraction.
  Fereshteh Golfakhrabadi , Seyed Nasser Ostad , Mitra Hafizi , Mohammad Reza Shams Ardekani , Soodabeh Saeidnia , Tahmineh Akbarzadeh and Mahnaz Khanavi
  Ferulago carduchorum Boiss and Hausskn (Apiaceae) is an endemic plant in West of Iran and it are used in dairy and oil ghee as a natural preservative. The aerial parts of F. carduchorum were extracted by percolation method with MeOH/H2O (80/20) and the fractions were provided respectively with hexane, ethyl acetate, methanol, methanol/H2O (50/50). The fractions have been investigated their phytochemical screening and the cytotoxic activity against the colon carcinoma (HT29), the breast ducal carcinoma (T47D), the hepatocellular carcinoma (HepG2) and Swiss mouse embryo fibroblast (NIH 3T3) cell lines by MTT (3-(4, 5-di methyl thiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay. Phytochemical screening revealed the presence of phytosteroids, flavonoids, coumarins and saponins. The cytotoxicity of ethyl acetate and hexane fractions showed more efficacy than the other fractions on T47D and HepG2 cell lines (IC50<100 μg mL-1) could be attributed to their content of coumarins and phytosteroids. The hexane fraction was selected for phytochemical study and suberosin (a coumarin) isolated from hexane fraction as an active compound. The Selective Index (SI) value of ethyl acetate fraction was lower in HepG2, T47D and HT29 cell lines than hexane fraction that indicated the selective effect of ethyl acetate fraction on this cell lines.
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