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Articles by Mahmoud Rafieian-Kopaei
Total Records ( 4 ) for Mahmoud Rafieian-Kopaei
  Najmeh Kabiri , Mahboobeh Ahangar Darabi , Mahmoud Rafieian-Kopaei , Mahbubeh Setorki and Monir Doudi
  The aim of this study is to evaluate the possible protective effects of Kombucha tea against thioacetamide induced liver damage in rats. A total of 24 male Wistar rats were divided into four groups: Control, treated with thioacetamide (TAA) treated with TAA and then Kombucha tea, treated with Kombucha tea and then TAA; following 3 weeks of treatment. All the animals were killed and liver tissue samples were obtained for histopathological investigation. The data showed that TAA significantly increased aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) but not bilirubin. The treatment by Kombucha tea promoted a significant reduction in serum enzyme levels AST, ALT, ALP, LDH and reduction in bilirubin content. The results show that the Kombucha tea has protective effects against the thioacetamide induced hepatotoxicity that might be due to antioxidant activities of these plants.
  Majid Asadi-Samani , Mahmoud Rafieian-Kopaei and Nafise Azimi
  Gundelia (Gundelia tournefortii L.) is a member of the Asteraceae (Compositae) family which grows in the semi-desert areas of Iran, Jordan, Palestine, Syria, Iraq, Syria, Azerbaijan, Armenia, Anatolia and other countries. Traditionally, G. tournefortii (L.) is used for treatment of liver diseases, diabetes, chest pain, heart stroke, gastric pain, vitiligo, diarrhea and bronchitis. It is also reported to have hypoglycaemic, laxative, sedative, anti-inflammatory, anti-parasite, antiseptic and emetic effects. It has enhanced gingivas and removed water from patients having spleenomegaly. Compounds found in gundelia proved to have several pharmacological effects, e.g. antibacterial, anti-inflammatory, hepatoprotective, antioxidant, antiplatelet and hypolipemic activities. The observed pharmacological properties indicated a close association of these effects with infectious diseases, digestive disorders, high blood pressure and cancer. In traditional medicine, this plant has been prescribed in many disorders; therefore, clinical trials on the compounds of gundelia seem essential. This study gives an overview of traditional uses of gundelia, irrespective of pharmacological studies on its effects.
  Mahmoud Gh. Mirzaei , Mojtaba Azimian , Mahmoud Rafieian-Kopaei and Bijan Khorasany
  Lamotrigine is effective in migraine with aura (classic migraine). However, its usefulness in migraine without aura (common migraine) is not clearly established. The purpose was to investigate the activity of lamotrigine on migraine with aura in comparison with any activity on migraine without aura in younger patients. In the study, 155 patients aged 4-14 years, suffering migraine headaches were diagnosed using International Headache Society (IHS) criteria. About 24 (15.5%) patients suffered classic migraine and 131 (84.5%) had common migraine. Each patient was prescribed lamotrigine (0.5 up to 3 mg/kg/day) for 6 months and evaluated monthly. Migraine frequency and intensity were recorded for 2 months before drug usage and 6 months during lamotrigine administration (acetaminophen was prescribed if needed). Lamotrigine induced a 45.2 and 17.1% reduction in the frequency of migraine attacks with and without aura, respectively. It also produced a 41.3 and 28.9% reduction in intensity of migraine with and without aura, respectively. About 14 patients in the classic migraine group and 23 patients in common migraine group were markedly improved (p<0.001). The results demonstrate that in younger patients, lamotrigine reduces both frequency and intensity of migraine in the presence and absence of aura.
  Hojjat Rouhi-Broujeni , Esfandiar Heidarian , Pariya Darvishzadeh-Boroojeni , Mahmoud Rafieian-Kopaei and Mojgan Gharipour
  Hyperlipidemia is the most important cardiovascular risk factor. Moringa peregrina is traditionally used as antihyperglycemia and antihyperlipidemia. This study aimed to investigate, the effects of hydroalcoholic extract of Moringa peregrina on lipid profile and atherogenic biomarkers of hyperlipidemic rat. In this experimental study, 40 male Wistar rats were divided into four equal groups: Normal rats, high fat diet rats (hyperlipidemia induced with persintra-M) high fat diet with Moringa peregrina, high fat diet plus atorvastatin. The regimens were given orally (by gavage) for 40 days. Also, serum lipid profile, thiol level, Malondyaldehide (MDA), antioxidant capacity, ferritin, CRP as well as atherogenic index were determined. Treatment with Moringa peregrina seeds significantly decreased serum LDL, VLDL, trigeliceride and total cholesterol and increased HDL-C. The Atherogenic index decreased. Also, MDA, ferritin and CRP were reduced and plasma thiol level icreased. The data demonstrates that the leaves ethanolic extract of Morninga peregrina has antioxidant activity and antilipidemic effect on hyperlipidemic rats. Also, reduction of lipid and protein peroxidation as an index of oxidative stress is evident.
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