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Articles by Mahmoud Abu-Samak
Total Records ( 7 ) for Mahmoud Abu-Samak
  Mahmoud Abu-Samak , Rula Khuzaie , Moayad Khataibeh and Fahmi Mahmoud
  The effects of MSH on whole blood viscosity (WBV)and hematocrit (Ht) levels in short-term alloxan-induced diabetic were studied. Male and Female Sprague-Dawley diabetic rats weighing 185-250 g were given intraperitonially (i.p.) a daily injection of 20 mg alloxan solution/100 g of body weight for 10 days. Normal and diabetic rats were given daily injection (i.p.) of alpha-Melanocyte stimulating hormone (MSH) at a dose of 2 μg/100 g b.w for 10 days. Body weight, serum glucose, serum insulin, Ht and WBV were measured. The results indicated that MSH decreased serum glucose levels in diabetic rats in comparison with normal rats. Our study demonstrates that MSH administration significantly lowers blood viscosity of short-term diabetic rats. It proposed that MSH may exert a protective effect on the vascular endothelial cells.
  Moayad Khataibeh , Khalid Abu-Alruz , Omar Al-Widyan , Mahmoud Abu-Samak and Jafar Al-Qudah
  The study was designed to investigate the chemoprotective effect of Combined Supplementation of soy and garlic on 7,12-dimethylbenz[α]anthrance (DMBA) induced mammary cancer in female Albino rats. Animals (eighty rats) where equally divided into four groups, (twenty rats each). Group I: each rat received 1 mL of 0.1% saline daily for twenty days. Group II: received 1 mL of 0.1% saline given orally once a day for twenty days after DMBA infusion (30 mg kg-1) and these rats served as controls (cancer control) for groups III and IV. Group III: were post treated with garlic after Infusion with DMBA. Group IV: Treated with Combined Supplementation of Soy and Garlic after DMBA infusion. Biochemical measurement were carried out on liver tissues and serum of experimental animals. Circulating levels of lactate dehydrogenase (LDH), glutamate oxaloacetate transaminase (GOT) and glutamate pyrovate transaminase (GPT) were elevated, while the activities of glutathione-s-transferase (GST) and superoxide dismutase (SOD) and the levels of reduced glutathione (GSH) were reduced in liver tissues in DMBA infused rats as compared to normal. Combined Supplementation of Soy and Garlic treatment altered the above mentioned biochemical parameters towards normal values. Present findings indicate that combined supplementation of soy and garlic got more marked effect on DMBA infused rats as compared to a group of rats received only garlic treatment.
  Mahmoud Abu-Samak , Moayad Khataibeh and Aurelia Crevoi
  The changes induced by MSH after short-term alloxan -induced diabetes mellitus on both male and female Sprague Dawley rat’s serum T4 and T3 were evaluated. Serum hormones were determined by specific radioimmunoassays and short-term diabetes mellitus induction was carried out by daily injection of 20 mg alloxan solution/100 g body weight intraperitonially for 10 days. Mean serum T4 was significantly decreased to 11.044±2.588 nmol L-1 and serum T3 to 0.132±0.0137 nmol L-1 in diabetic rats. After 10 days with daily injection of alpha-MSH at a dose of 2 μg/100 g body weight, serum T4 increased significantly up to 82.557±25.815 nmol L-1 and serum T3 increased up to : 1.027±0.311 nmol L-1. The results can be explained by the role of the Melanocyte Stimulating Hormone in the peripheral regulation of thyroid function and that it may act as a mediator of hyperglycemia effects on the HPT axis.
  Mahmoud Abu-Samak , Al-Motassem Yousef , Ahmad Al-Jarie , Hisham Y. Al-Matubsi , Ahmed Abu-zaiton, , Mamoun Al-Quraan and Rula Khuzaie
  To analyze the influence of hyperleptinemia on fasting lipid and hematological parameters in healthy Arab male youth in Jordan, this cross-sectional study was carried out in April 2009 on a sample of 120 students aged 18-24 years. Subjects were stratified by fasting leptin into two groups (control, <12.7 ng mL-1 vs. hyperleptenimic, e_<12.7 ng mL-1) and BMI (normal weight, <25 kg m-2 vs. overweight/obese, BMI e_<25 kg m-2). Fasting serum leptin, blood glucose, lipid profile and hematological parameters values were determined by standard kit methods. Mean serum leptin concentrations were more than five times as high in hyperleptenemic subjects than in control subjects (p<0.001). Compared with control group, significant elevations (p<0.01) were observed in the means total cholesterol, LDL cholesterol and triglyceride levels of hyperleptenemic group whereas no significant differences was detected in HDL-cholesterol. Except the changes of WBC count, MCH and slightly MCHC, there were no differences between both groups in any other term of hematological parameters. In conclusion, changes in lipid variables and some hematological parameters may increase plasma viscosity as a step during atherosclerosis pathogenesis in male youth at risk for dyslipidemia and cardiovascular diseases. Thus, hyperleptinemia could be a useful index in identifying healthy youth male subjects but this hypothesis needs further investigation.
  Hisham Y. Al-Matubsi , Nagham A. Nasrat , Ghaleb A. Oriquat , Mahmoud Abu-Samak , Khtan A. Al-Mzain and Maher Salim
  The current study investigated the effect of natural diosgenin extracted from fenugreek seeds, in comparison with the pure standard diosgenin, plus chromium chloride (CrCl3) supplementation on high-cholesterol fed Japanese quails. Quails were randomly divided into four groups. Group one (n = 25) fed experimental diet only (control; contained basal diet supplemented with 1% cholesterol), group 2 (n = 20) fed experimental diet supplemented with CrCl3 only (400 μg kg-1 of body weight), groups 3 and 4 (n = 30 per group) were fed experimental diet supplemented with either 0.5% (w/w) of extracted diosgenin plus CrCl3 or pure standard diosgenin (0.5%) plus CrCl3 respectively, for 12 days. Blood samples were collected at days 0 and 12 for measuring levels of lipid profile. The work was carried out at Applied Science University and Amman University, Amman, Jordan during the period from October 2009 through October 2010. The mean levels of total cholesterol (TC) in control quails at d12 was significantly (p<0.01) increased compare to those at d0. Supplementation of diet with CrCl3 alone or CrCl3 with diosgenin either extracted or pure standard for 12 days showed a significant (p<0.01) decrease in TC and low density lipoprotein cholesterol (LDL-C) levels as compared to those in the control quails. While, high density lipoprotein cholesterol (HDL-C) increased significantly (p<0.01) in quails supplemented with diosgenin and CrCl3. At d12, the mean Superoxide Dismutase (SOD) activities in erythrocytes of quails in all supplemented groups was significantly (p<0.01) increased as compared to those in control group and was more pronounced in erythrocytes of quails supplemented with pure standard diosgenin plus CrCl3. These results indicated that the combined diosgenin and CrCl3 supplementation to high-cholesterol fed quails might induce a protective effect by both regulating lipid and antioxidative damage.
  Mahmoud Abu-Samak , Fahmi Mahmoud , Moayad Khataibeh , Suhail Hamdan and Aurelia Crevoi
  This study was designed to investigate the effects of Melanocyte stimulating hormone MSH on serum testosterone T and estradiol E2 hormones concentrations in alloxan-induced diabetic rats. Eighty male and female Sprague Dawley rats, weighing 180-200 g, were divided into four groups of normal rats and four groups of alloxan-induced diabetic rats were given intraperitonially (i.p.) a daily injection of 20 mg alloxan solution/100 g of body weight for 10 days. Two groups, male and female from the normal and 2 diabetic groups served as controls and did not inject with MSH 2 groups, male and female from the normal rats and 2 groups from the diabetic rats injected (i.p) daily with MSH at a dose of 2-microg/100 g of body weight, for 10 days. The control group was only injected with the same volume of normal saline. Serum glucose concentrations were higher and serum insulin, testosterone and estradiol concentrations were lower in diabetic rats than those in the control groups. MSH administration decreased the elevated blood glucose concentrations of the diabetic rats to the normal levels and decreased estradiol concentration in female normal rats while increased the testosterone concentration in male normal rats. Present findings indicate that MSH plays adaptive role during early stages of alloxan induced-diabetes mellitus. Further studies are needed to identify the mechanism.
  Ahmed Abu-Zaiton , Mahmoud Abu-Samak , Sawsan Oran , Israa Yousef , Yousef Abu-Zaitoon and Ayah Algaramseh
  The aim of this study is to investigate the anti-hyperglycemic effect, lipid profile and the activity of certain hepatic enzymes of the ethanolic extract of the plant Arbutus andrachne on streptozotocin-induced diabetic rats. About 30 Wistar albino rats weighing between 180-200 g were randomly classified into four categories of six albino rats. The normal control group (group A) was treated orally with distilled water. The diabetic control group (group B) was induced by streptozotocin. So, this group is considered as a negative control. The non diabetic rats (group C) which was treated with the ethanolic extract of the plant A. andrachne that collected from Jerash/Jordan of a dose 200 mg kg–1. The last group (Group D) which included the diabetic rats that treated with 200 mg kg–1 of the ethanoilc extract of the plant A. andrachne. The treatment was carried out daily for 14 days. The glucose, triglycerides, cholesterol and hepatic enzymes levels were quantified in serum of experimental rats. Faculty of Pharmacy/Applied Science University (December, 2018) and Botany Lab, Department of Biological sciences/University of Jordan. The results unambiguously showed that there was significant declines (p<0.05) in triglycerides and glucose levels in albino rats that treated with A. andrachne ethanolic extract compared with group B, the control group of diabetic rats. Significant reduction (p<0.05) in hepatic enzymes -AST and ALT-levels were also observed in rats treated with the plant ethanoilc extract compared with group B experimental rats. However, no significant changes in the cholesterol level were observed in the treated rats compared with the control group. Data in this piece of research revealed that the plant A. andrachne ethanolic extract has both hypoglycemic and hypolipidimic effect. This extract is suggested to reduce the liver damage induced by streptozotocin through maintaining the activity of hepatic enzymes.
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