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Articles by Mahmoud M. Alagawany
Total Records ( 2 ) for Mahmoud M. Alagawany
  Mayada R. Farag , Mahmoud M. Alagawany and Kuldeep Dhama
  This study was conducted to verify whether Turmeric (Curcuma longa) has the potential to modulate the cytogenotoxic and immunotoxic effects resulting from exposure to endosulfan in broiler chicks. For this purpose, 180 one day old chicks were divided randomly into 6 groups of 30 chicks each, divided into 3 replicates. First group was fed basal diet, while the other five groups were fed basal diet supplemented with 5 g turmeric, 10 g turmeric, 30 mg endosulfan, 30 mg endosulfan plus 5 g turmeric and 30 mg endosulfan plus 10 g turmeric/kg diet, respectively, during the experimental period. At the end of the experiment, blood and spleen samples were collected and evaluated for genotoxicity, cytotoxicity and immunotoxicity biomarkers induced by endosulfan. Also, histopathological investigation of the spleen tissue was conducted. A significant increase in genotoxicity and cytotoxicity biomarkers (micronucleusfrequency, DNA fragmentation, 8-hydroxy-2-deoxyguanosine level (8 OHdG) and lactate dehydrogenase activity (LDH)) was recorded in endosulfan treated chicks. In addition, the immunotoxicity biomarkers showed a significant decrease in phagocytic percentage, stimulated Nitric oxide (NO) production and decrease in the serum lysozyme activity. Histopathological findings supported the cytotoxicity results. Dietary supplementation of turmeric at different levels ameliorated deleterious effects of endosulfan and restored them to be near control level. The results of the study suggested that regular consumption of turmeric in the diet is a promising approach in attenuating the disturbances induced by endosulfan in the most studied biomarkers.
  Mahmoud M. Alagawany , Mayada R. Farag , Kuldeep Dhama , Mohamed E. Abd El-Hack , Ruchi Tiwari and Gazi Mahabubul Alam
  The polyphenol resveratrol is an antioxidant nutrient, used to enhance growth performance through activation and modification of gut function and structure and to inhibit cancer initiation and promotion. The main application of resveratrol is in animal and poultry nutrition, in particular as a feed additive to reduce free radicals in a wide variety of animal species. Several studies carried out on diets supplemented with additives containing natural antioxidants as resveratrol demonstrated its capability to improve the productive performance, immune response and health of livestock besides reducing the risks of various animal diseases such as cancer and other degenerative diseases. Such activities could be attributed to its powerful antioxidant, immunomodulatory and anti-inflammatory effects by preventing free radicals from interacting with cellular DNA and its ability to alter the intestinal microbiota, increased digestibility and absorbance of nutrients. This review describes the modes of action, metabolism, the biological activities, natural sources and beneficial aspects/potential applications of resveratrol in animal and poultry nutrition, production and health.
 
 
 
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