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Articles by Mahmoud El-Sherbiny
Total Records ( 2 ) for Mahmoud El-Sherbiny
  S.A. Maghraby , Kamel H. Shker , H.G. Zahran and Mahmoud El-Sherbiny
  Antischistosomal activity, identification and immunoprophylatic effects of a crude Faciola gigantica worms homogenate, F. gigantica worms homogenate mixed with saponin were studied on Schistosoma mansoni infected mice. Mice were divided into four groups (10 animals group). First group was immunized subcutaneously (50 μg/mouse/100 μL/PBS) at 0 and 15 days with a crude F. gigantica worms homogenate, second group was immunized subcutaneously with a crude F. gigantica worms homogenate mixed with saponin and, third group was immunized with saponin only. The fourth group was used as control. Post second immunization mice were infected by tail immersion with 100 Schistosoma mansoni cercariae per each mouse. Relative to electrophoretic analysis and scanning of the standard of known molecular weights, the number of major bands detected from electrophoretic scanning of Faciola gigantica worms homogenate were 8 bands, 177.30, 156.81, 110, 105.95, 102.47, 64.084, 56.403 and 45.893 KDa. The electrophoretic scanning of a crude Faciola gigantica worms homogenate mixed with saponin showed that 7 bands, 120.49, 112.38, 102, 91.727, 86.203, 69.794 and 66.825 kDa. On the other hand, the number of major bands detected from the electrophoretic scanning of saponin were 9 bands, 167.68, 110, 104.94, 102, 92.620, 79.399, 60, 54.231 and 23.091 KDa. Perfusion and recovery of adult worms were performed at 8 weeks post infection. Immunization with a crude F. gigantica worms homogeneta, a crude F. giganatica worms homogeneta mixed with saponin and saponin only recorded reduction in total worms by 75.11, 45.24 and 87.33%, respectively. The level of both IgM and IgG from sera of immunized mice with a crude F. gigantica worms homogenate, a crude F. gigantica worms homogenate mixed with saponin and saponin only showed an increasing against cercarialantigen preparation, soluble worm antigen preparation and soluble egg antigen using Enzyme Linked Immunosorbent Assay (ELISA). Using immunolymphocytes stainingpreparation, the mean number of splenocytes that were prepared from immunized groups with a crude F. gigantica worms homogenate, a crude F. gigantica worms homogenate mixed with saponin and saponin without homogenate , respectively showed a significant increase (p<0.05) as compared with non immunized group.
  Sohair Aly Hassan and Mahmoud El-Sherbiny
  A new Bladder Tumor Marker has been developed to detect early TCC bladder cancer. Objective to evaluate the Bladder Tumor Marker (BTM) as a new developed tumor marker in comparison to cytology. Transurethral specimens and voided urine samples were collected from 30 patients with haematuria selected from inpatients of Theodur Bilharz Institute-Cairo. The samples were diagnosed according to histopathological examination into 25 samples with TCC, 5 samples were served as control since they were complains of no cancerous symptoms and were suffering from other genitourinary pains. Urine samples were tested by BTM and cytology. The results were correlated with the final diagnosis (histopathology) and with tumor grade and stage. Sensitivity of BTM test was 72% and specificity was 60%. The corresponding cytology results were 44 and 100%, respectively. BTM was highly sensitive in grade I and stage I, 86 and 89% in comparison to 57 and 33% in cytology. Cytology appeared to be highly sensitive in grade III compared to BTM, 80 and 60%, respectively. BTM is more sensitive and valuable in detecting low grade and stage compared to cytology for early detection of TCC bladder tumor.
 
 
 
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