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Articles by Maharani L. Apriasari
Total Records ( 2 ) for Maharani L. Apriasari
  Maharani L. Apriasari , Yoes P. Dachlan and Diah S. Ernawati
  Background and Objective: Gel of Musa acuminata stem from South Borneo had shown to accelerate wound healing by increasing the number of neovasculars on the 5th day. The study aimed to determine the effect of gel of Musa acuminata stem extract (EBPM) towards increased expression of HIF-1α, Hsp90α and VEGF in healing traumatic ulcer. Materials and Methods: This research was a true experimental with 40 rats of Rattus norvegicus of male Wistar strain as the traumatic ulcer models. The biopsy was taken from the ulcer in the left buccal oral mucous. The study was divided into the negative control group (K) given gel, treatment group 1 (P1) given gel of 25% EBPM, treatment group 2 (P2) given gel of 37.5% EBPM and treatment group 3 (P3) given gel of 50% EBPM. On the 3rd and the 5th days, the models were decapitated. They were next biopsied in order to make preparations and to conduct immunohistochemistry test. Results: The results proved that the EBPM gel was effective when administered at a concentration of 37.5% in the 5th day because it significantly increased the expressions of HIF-1α, Hsp90α and VEGF. Conclusion: It can be concluded that gel of Musa acuminata stem extract of 37.5% could increase neovascular number through increasing the expression of HIF1α, HSp90α and VEGF to accelerate oral ulcer healing, including traumatic ulcer. It has indicated that gel of Musa acuminata stem extract of 37.5% concentration can be recommended as a natural ingredient of topical drug to accelerate ulcer healing in oral mucous.
  Maharani L. Apriasari , Yusfa Ainah , Eka Febrianty and Amy N. Carabelly
  Background and Objective: Toman fish (Channa micropeltes) contains albumin which possesses antioxidant effect. People in south Kalimantan, Indonesia, use toman fish as an alternative drug to accelerate diabetic wound healing process. In diabetic wound, there is a reduction in superoxide dismutase (SOD) activity and an elevation in malondialdehyde (MDA) level which can lead to the occurrence of delayed wound healing. The objective of this study was to prove the antioxidant effect of Channa micropeltes using SOD activity and MDA level in diabetic wound of oral mucosa. Materials and Methods: This is an experimental study with post test-only control group design. This study used 24 Wistar rats which divided into three treatment groups. The groups comprised of one group administered with toman fish extract of 16 mL kg–1 rat BW per oral, one group as a positive control administered with Haruan fish extract of 13.54 mL kg–1 rat BW per oral and one group as a negative control given BR2 feed only. The SOD activity measurement was done through Misra and Fridovich method using spectrophotometer in 480 nm wavelength. The MDA level measurement was done through Thiobarbituric Acid (TBA) test from Buege and Aust method using spectrophotometry in 532 nm wavelength. Results: One-way ANOVA test of day 3 showed no significant difference in SOD activity (p = 0.078) and MDA level (p = 0.094). Meanwhile, statistical result of day 7 showed significant difference in SOD activity (p = 0.018) and MDA level (p = 0.011). Post-hoc LSD test showed significant difference between toman fish extract of 16 mL kg–1 rat BW dosage and haruan fish extract of 13.54 mL kg–1 rat BW dosage and group given BR2 feed only. Conclusion: It can be concluded that Channa micropeltes has an antioxidant effect which represented by the increase of SOD activities and the decrease of MDA level in diabetic wound of oral mucosa.
 
 
 
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