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Articles by Madiha Mahmoud
Total Records ( 2 ) for Madiha Mahmoud
  Saedia A. Sayed El-Ahl , Mai A. Hegazi , Madiha Mahmoud , Fatma El. Zahraa , M. Awadallah and Mona A. Abd Rabo
  The study explores the direct effect of somatostatin (SOM) on some stages of Schistosoma mansoni. Experimentally infected mice with Schistosoma mansoni were investigated following administration of either SOM, artemether (ART) or their combination. Each regimen was administered at 2, 5 and 13 weeks Post-infection (PI) to separate groups. The most presented period of worm reduction was in mice group received SOM at 5 weeks PI (44.28%), 2 weeks PI in ART administration (79.90%) and 2 weeks PI in combined treated group (84.16%). A significant reduction in mature ova (p<0.05) was recorded in ART and combined treated groups at administration 2 weeks PI in addition to an increase in immature and dead ova in all treated groups than controls. The highest percentage reduction of total egg load was recorded in combined treated groups at 2, 5 and 13 weeks PI (88.4, 85.74 and 56.93%), respectively compared to other regimens. The morphological changes of the adult worms in SOM treated groups were elongation, erraticism, agitation and fragility. Male worms showed poorly developed suckers and tuberculations. Both male and female worms showed empty intestines. In ART treated group the male worms showed stunted growth and deformity of suckers. In female worms beside stuntedness, they showed moderately developed ovary, empty intestine and absence of vitelline glands. These observations were highly pronounced in worms recovered from combined treated groups. The study concluded that SOM has an inhibitory role on the parasite of Schistosoma mansoni itself regarding physiological development, worm reduction, egg production and maturity.
  Mai A. Hegazi and Madiha Mahmoud
  The study aimed to examine the effect of combined therapy of artemether (ART) and somatostatin (SOM) on liver fibrosis in experimentally infected mice with Schistosoma mansoni. Infected mice were investigated following administration of either SOM, ART or their combination. Each regimen was administered at 2, 5 and 13 weeks post-infection (PI) to separate groups which were respectively sacrificed at 5, 8 and 16 weeks PI. Liver fibrosis was assessed by chemical measurement of heptic hydroxyproline as a marker of collagen content in liver. The extent of infection was monitored by liver egg load. The results were interpreted in comparison with corresponding ones in untreated S. mansoni-infected mice and age-matched normal control mice. Combined treated group showed the highest significant lower mean of hepatic hydroxyproline content than the infected control in 2, 5 and 13 weeks PI (793.41±64.91, 1010.87±75.67 and 1021.42±135.60) respectively in comparison to control group. ART administration group attained nearby significant lower measures as that of combined therapy group in the three successive periods of the experiment (893.57±31.83, 1035.91±42.24, 1228.34±26.52) in comparison to control group. SOM treated group attained significant lower hydroxyproline content in only 5 weeks PI (1145.30±80.91) and 13 weeks PI (1154.53±60.84). The study concluded that the combined therapy seemed not to be more effective than ART alone. By implication SOM therapy does not appear to have an additive effect on ART treatment.
 
 
 
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