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Articles by MEI Yu
Total Records ( 5 ) for MEI Yu
  Sheng Ding , Mei Yu , Fucui Li , Xin Jin , Yang Song and Gangyi Jiang
  In this study, a novel Reduced Reference Image Quality Assessment (RR-IQA) metric is proposed based on energy change in wavelet domain. In the first place, features of Gaussian blur images and their general properties in wavelet domain are analyzed, in terms of the corresponding significance they play on the representation of human visual system. Secondly, in accordance with some authoritative literatures, the change of image energy will evoke the change of human visual perceptual quality. Based on this fact, a series of features from Gaussian blur images which embody the change of image energy are extracted. Finally, we fuse these features based on the principal that we exert different importance in accordance with the different impact each individual sub-band plays on the visual perception. As far as the performance of the proposed metric for the Gaussian blur images is concerned, the proposed metric outperforms the state-of-the-art RR-IQA metrics and even two typical full-reference image quality assessment metrics.
  Byron Zhao , Mei Yu , Martin Neitzel , Jennifer Marugg , Jacek Jagodzinski , Mike Lee , Kang Hu , Dale Schenk , Ted Yednock and Guriqbal Basi
  Production of amyloid β peptides (Aβ), followed by their deposition in the brain as amyloid plaques, contributes to the hallmark pathology of Alzheimer disease. The enzymes responsible for production of Aβ, BACE1 and γ-secretase, are therapeutic targets for treatment of Alzheimer disease. Two presenilin (PS) homologues, referred to as PS1 and PS2, comprise the catalytic core of γ-secretase. In comparing presenilin selectivity of several classes of γ-secretase inhibitors, we observed that sulfonamides in general tend to be more selective for inhibition of PS1-comprising γ-secretase, as exemplified by ELN318463 and BMS299897. We employed a combination of chimeric constructs and point mutants to identify structural determinants for PS1-selective inhibition by ELN318463. Our studies identified amino acid residues Leu172, Thr281, and Leu282 in PS1 as necessary for PS1-selective inhibition by ELN318463. These residues also contributed in part to the PS1-selective inhibition by BMS299897. Alanine scanning mutagenesis of areas flanking Leu172, Thr281, and Leu282 identified additional amino acids that affect inhibitor potency of not only these sulfonamides but also nonsulfonamide inhibitors, without affecting Aβ production and presenilin endoproteolysis. Interestingly, many of these same residues have been identified previously to be important for γ-secretase function. These findings implicate TM3 and a second region near the carboxyl terminus of PS1 aminoterminal fragment in mediating the activity of γ-secretase inhibitors. Our observations demonstrate that PS-selective inhibitors of γ-secretase are feasible, and such inhibitors may allow differential inhibition of Aβ peptide production and Notch signaling.

  Hu Zeng , Yuhong Chen , Mei Yu , Liquan Xue , Xiang Gao , Stephan W. Morris , Demin Wang and Renren Wen
  Previous studies have demonstrated that Bcl10 (B-cell leukemia/lymphoma 10) is essential for T cell receptor-mediated NF- B activation and subsequent proliferation and interleukin 2 (IL2) production. However, here we demonstrate that, contrary to expectations, Bcl10 is differentially required for T cell activation, including for both proliferation and cytokine production. When CD4+ and CD8+ T cells were divided based on expression levels of CD44, which distinguishes naïve cells (CD44lo) versus those that are antigen-experienced (CD44hi), IL2 production by and proliferation of CD4+CD44lo naïve cells and both subpopulations of CD8+ T cells were clearly Bcl10-dependent, whereas these same functional properties of CD4+CD44hi T cells occurred largely independent of Bcl10. As with the other subpopulations of T cells, CD4+CD44hi T cells did not activate the NF- B pathway in the absence of Bcl10; nevertheless, these CD4+CD44hi antigen-experienced T cells efficiently secreted IL2 after T cell receptor stimulation. Strikingly, therefore, T cell receptor-mediated IL2 production in these cells is NF- B-independent. Our studies suggest that antigen-experienced CD4+ T cells differ from their naïve counterparts and from CD8+ T cells in their ability to achieve activation independent of the Bcl10/NF- B pathway.
  Yabing Chen , Xiaohong Wang , Lie Di , Guoping Fu , Yuhong Chen , Li Bai , Jianzhong Liu , Xu Feng , Jay M. McDonald , Sue Michalek , Yinghong He , Mei Yu , Yang-Xin Fu , Renren Wen , Hui Wu and Demin Wang
  Phospholipase Cγ2 (PLCγ2) is an important signaling effector of multiple receptors in the immune system. Here we show that PLCγ2-deficient mice displayed impaired lymph node organogenesis but normal splenic structure and Peyer`s patches. Receptor activator of NF-κB ligand (RANKL) is a tumor necrosis factor family cytokine and is essential for lymph node organogenesis. Importantly, PLCγ2 deficiency severely impaired RANKL signaling, resulting in marked reduction of RANKL-induced activation of MAPKs, p38 and JNK, but not ERK. The lack of PLCγ2 markedly diminished RANKL-induced activation of NF-κB, AP-1, and NFATc1. Moreover, PLCγ2 deficiency impaired RANKL-mediated biological function, leading to failure of the PLCγ2-deficient bone marrow macrophage precursors to differentiate into osteoclasts after RANKL stimulation. Re-introduction of PLCγ2 but not PLCγ1 restores RANKL-mediated osteoclast differentiation of PLCγ2-deficient bone marrow-derived monocyte/macrophage. Taken together, PLCγ2 is essential for RANK signaling, and its deficiency leads to defective lymph node organogenesis and osteoclast differentiation.
  MEI Yu , MA Ming , HU Bao-wen , Dusan Brinkhuizen and Tamas Szekely
  The nest-site selection of White-crowned Penduline Tit Remiz coronatus in Northern Xinjiang was studied from April to July in 2008. It has special nesting behavior. The nest has a pocket pouch size, with a delicate structure. Research of the nest, using the method of total area investigation, included searching for nests carefully, combined with tag plotting method, and drawing the nest distribution map. In total 125 nests were found in the field, nesting on willow, poplar, birch and other hardwood trees near lakes and rivers. 68.80% of nest trees were willows Salix spp. The average height of nests was 5.3±2.5 m. The nests were located in the lower part of arbor (about 1/3), about 70% of nests less than 30 meters from river. Study of the nest-site selection, used a quadrate survey to investigate the parameters of nest-site characteristics. The principal component analysis indicated that there were four factors affecting the nest-site selection of the White-crowned Penduline Tit. They were: 1. canopy (including diameter of nest tree and canopy cover above nest), 2. nest tree species (including species of nest tree and arbor, height of nest tree and nest in the tree), 3. position or site (including distance to river and nest orientation ), 4. food and nest material (including canopy cover under nest).
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