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Articles by M.Z. Asmawi
Total Records ( 5 ) for M.Z. Asmawi
  O.Z. Ameer , I.M. Salman , M.F. Yam , H.H. Abd Allah , M.H. Abdulla , A.M. Shah , A. Sadikun and M.Z. Asmawi
  In the present study, Loranthus ferrugineus was evaluated for blood pressure lowering activity using in vitro and in vivo animal experimental approaches. The fresh aerial parts of the plant were dried, pulverized into powder and successively extracted with petroleum ether, chloroform, ethyl acetate, methanol and water using hot extraction methods. Each of the extracts was dried under reduced pressure using rotary evaporator and subsequently freeze-dried. The effects of three different concentrations (0.5, 1 and 2 mg mL-1 of each extract were examined on isolated rat aortic ring preparations and responses to cumulative doses of noradrenaline (NA) were measured. It was found that the relatively polar methanol extract was the most potent to produce a significant (p<0.05) dose-dependent inhibition in the maximum response and to shift the dose-response curve of NA to the right which suggests that Loranthus ferrugineus methanolic extract (LFME) contains compound(s) with non-competitive inhibitory activity. In another set of experiments, LFME was found to be the most active in blood pressure lowering activity in anesthetized normotensive Sprague Dawley (SD) rat model. Moreover, LFME produced a dose-dependent blood pressure lowering effect. Chemical analysis of LFME showed the presence of significant amounts of polyphenolic and flavonoid constituents. The data suggests that LFME contains some biologically active substances that produce a significant dose-dependent blood pressure lowering effect and vasodilatation is one of the possible mechanisms which may explain its use in the management of hypertension. Furthermore, LFME effects can possibly be attributed to the high polyphenolic contents of this plant.
  H.B. Sahib , A.F. Aisha , M.F. Yam , M.Z. Asmawi , Z. Ismail , S.M. Salhimi , N.H. Othman and A.M.S. Abdul Majid
  Angiogenesis is a process by which new blood vessels are formed from the pre-existing blood vessel. Orthosiphon stamineus Benth. OS has been used as a medicinal herb for many centuries. Due to the presence of high level of anti-oxidants and phenolic content compounds in OS and the effect of anti-oxidants and phenolic compounds being anti-angiogenic, the perturbation of new blood vessels ability of OS was tested. Dry powdered leaves of the OS plant were extracted with Petroleum Ether (PE), chloroform (CE), methanol (ME) and water (WE) by using sequential cold maceration method. The ME of OS has the highest anti-angiogenic activity (93.28±1.24%) in the rat aortic assay followed by CE (85.55±1.64%), PE (51.54±4.12%) and WE (50.22±1.23%) in descending order of reactivity. The methanol extract was also found to have potent anti-oxidant activity in the1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay. The IC50 value was measured to be 0.286 mg mL-1. The total phenolic content of 1 mg mL-1 of methanol extract was equal to 38.27%.
  O.Z. Ameer , I.M. Salman , Md. J.A. Siddiqui , M.F. Yam , R.N. Sriramaneni , A.F. Mutee , A. Sadikun , Z. Ismail and M.Z. Asmawi
  The aim of the current investigation was to examine the vascular responsiveness to different extracts obtained from M. cochinchinensis using isolated Sprague Dawley (SD) rat aortic rings preparations. The fresh aerial parts of the plant were dried, pulverized into powder and sequentially extracted with petroleum ether, chloroform, methanol and water using hot extraction method. The effects of three concentrations (0.5, 1 and 2 mg mL-1) of each extract on rat thoracic aorta were tested using cumulative concentrations of noradrenaline (NA). The data showed that all the extracts had the ability to relax vascular smooth muscle; however, high concentrations of the methanol and water extracts caused the most significant (p<0.05) reduction in NA-induced vasoconstriction as compared to petroleum ether and chloroform extracts. Polyphenolic content, HPLC profiling and IR spectra were indicative of the presence of diterpenoid constituents. The results collectively suggested the presence of some biologically active ingredients of possible diterpenoid nature that have the ability to modulate the action of naturally occurring vasoactive agents such as NA on vascular smooth muscle responses in vitro.
  A.F. Mutee , S.M. Salhimi , M.F. Yam , C.P. Lim , G.Z. Abdullah , O.Z. Ameer , M.F. Abdulkarim and M.Z. Asmawi
  Peperomia pellucida is widely used in the traditional medicine such as in the treatment of inflammation, gout, arthritis and wound healing. The present study was performed to evaluate the anti-inflammatory and antioxidant effects of petroleum ether, chloroform and methanol extracts of P. pellucida. The carrageenan-induced rat hind paw edema method was performed to evaluate the anti-inflammatory effect in vivo and the determination of free radical scavenging activity method was carried out to assess the antioxidant effect in vitro. For the anti-inflammatory activity, 1000 mg kg-1 of petroleum ether extract significantly reduced carrageenan-induced hind paw edema (p<0.05) compared with the control (p<0.01). However, there was no significant anti-inflammatory activity for chloroform and methanol extracts. The antioxidant effect was evaluated by determining the free radical scavenging activity of the three extracts. The total phenol content was determined for the methanol extract (6.93%) that showed the strongest free radical scavenging activity (0.083 mg mL-1 ±0.008). Petroleum ether and chloroform showed low free radical scavenging activity compared to methanol extract. The results obtained from this study suggest that this plant is a good natural source for anti-inflammatory and antioxidant therapy.
  M.Z. Asmawi , O.M. Arafat , S. Amirin and I.M. Eldeen
  Crinum asiaticum is a perennial bulbous herb native to tropical South-eastern Asia. The plant is useful in Asian and African traditional medicine as an analgesic agent. This report aimed to investigate the antinociceptive effects of leaf extracts of Crinum asiaticum on rats and to highlight the major chemical groups of the bioactive fractions. Powdered leaf of Crinum asiaticum was sequentially extracted using petroleum ether, chloroform and methanol. The extracts were investigated for their antinociceptive activity on rats using the carrageenan-induced paw hyperalgesia method. Pain threshold response was measured by applying pressure on the rat's paw using analgesy-meter. Oedema was induced by injection of 0.1 mL 1% (w/v) carrageenan dissolved in normal saline into the footpad of the right hind paw of the rat and allowed to develop. The test samples were administered orally in a dose of 1000, 500 and 250 mg kg-1 (10 mL kg-1). Rats administered orally with vehicle were used as negative group. Indomethacin (1 mg kg-1) was used as positive control. After 4 h, the pain threshold of each rat was measured. The best activity was shown by the chloroform extracts at the dose of 250 mg kg-1 (n = 4-5 in each group; p<0.05), followed by the methanol extracts. No activity was observed with the petroleum ether extract (1000 mg kg-1). Indomethacin was used as positive control (1 mg kg-1). Phytochemical screening of the active fractions indicated the presence of alkaloids, coumarins, glycosides, triterpenes and flavonoids. The results obtained support the reported uses of the plant as traditional analgesic agent.
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