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Articles by M.Y. Sugun
Total Records ( 3 ) for M.Y. Sugun
  A.A. Masdooq , A.E. Salihu , A. Muazu , A.K. Habu , J. Ngbede , G. Haruna and M.Y. Sugun
  In this study, lung samples of chickens slaugtered at abattoir in Jos South, Nigeria were tested for the presence of Pasteurella multocida and other aerobic bacteria. The identity of P. multocida was proved by mouse pathogenicity test. A total of 3000 chickens were examined at post-mortem and 500 samples with pneumonia were collected. All lungs and heart blood from 15 different commercially reared chicken flocks showed respiratory disorders. Blood agar supplemented with 10% sheep blood was used for isolation of the agents.32 (6.5%) P. multocida were isolated and identified. In addition, mouse pathogenicity test was carried out on P. multocida suspected isolates. Twelve (75%) of Isolates were all positive. This study showed that P. multocida is not the most prevalent bacterial infection among chicken population in Jos south.
  Y.D. Dashe , M.A. Raji , P.A. Abdu , B.S. Oladele and M.Y. Sugun
  Antibiotic resistance is often encountered despite multiple antibiotics being used for the treatment of fowl cholera in Jos. This study was conducted to determine the antibiotic resistant profile of Pasteurella multocida isolated from chickens in Jos. A total of 2000 samples consisting of bone marrow, heart, liver, lung and spleen (400 each) were collected from 400 clinically sick chickens between November, 2010 and October, 2011 for the isolation of P. multocida. Swab from each sample was cultured on 7% defibrinated sheep blood, MacConkey and casein sucrose yeast agar. Presumptive colonies of P. multocida were subjected to biochemical characterization. Isolates identified by biochemical tests were further subjected to Microbact GNB 24E test. Disk diffusion method was employed to test the sensitivity of all the twelve P. multocida isolates confirmed by biochemical and Microbact GNB 24E test. The twelve pure isolates of P. multocida were tested for their sensitivity against fifteen different antibiotics. Drug sensitivity test conducted on P. multocida isolates showed that some of the isolates were resistant to penicillin 11 (73%), microlides 9 (60%), sulfanomides 8 (53.3%), cephalosporins 3 (20%) and other new groups of antibiotics 4 (27%). High resistance of P. multocida was recorded for ampicillin (91.7%) followed by amoxicillin/clavulanic acid (83.3%), trimethoprim/sulfamethoxazole (66.7%), erythromycin and anicillin (58.3%) each, while tylosin was (33.3%). This study revealed that there is an emergence of multidrug resistance in some P. multocida strains among chickens in Jos, Nigeria. It is therefore recommended that antibiotic sensitivity test should be incorporated on a routine bases as part of measure to control fowl cholera and minimize the emergence of P. multocida resistance.
  E.A. Ogunsan , A.A. Seawright , D.O. Ehizibolo , H.M. Tukur , M.S. Ahmed , Y.G. Dashe and M.Y. Sugun
  It has become apparent that inflammation provoked by injury to renal epithelial cells serves to amplify kidney injury and dysfunction in vivo Compounds including the sesquiterpene ketones generally believed to cause kidney injury by direct tubular toxicity or crystal nephropathy have been considered in different renal studies. The aim of this study was to highlight the histotoxicity of Deisopropylngaione (DIN) in mice. Ninety male quackenbush mice weighing between 30 and 35 g b.wt. were divided into five groups of fifteen mice per group and received 70, 98, 137, 192 and 268 mg kg-1 DIN intraperitoneally, respectively. Haematoxylin erosin (H and E) and Von Kossa stained histology slides showed proximal tubular necrosis and hyaline cast formation. Deposition of calcium salt in residual necrotic tubular epithelium was on the increase with increase in dose rate. Besides the pulmonary lesions seen in mice following intoxication by DIN, the kidney lesions were consistent with previous studies of these compounds in mice and similar to mercuric chloride poisoning in sheep.
 
 
 
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