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Articles by M.U. Eteng
Total Records ( 4 ) for M.U. Eteng
  F.E. Uboh , E.N. Asuquo , M.U. Eteng and E.O. Akpanyung
  Endosulfan is known to be one of the highly toxic agricultural pesticides commonly used in our societies. With the widespread use of endosulfan in agriculture, human beings are most likely to be exposed to it, either orally by eating endosulfan-contaminated foods or by nose and whole body inhalation in the farms during its application. In this study, we assessed the route-of-exposure-dependent effect of endosulfan on renal functions in male rats, using serum creatinine, urea, Blood Urea Nitrogen (BUN), uric acid, Na+, Cl¯ and K+, as well as histopathological assay. Eighteen mature male albino Wistar rats (200±20 g), divided into three groups of six rats each, were used in this study. The 20 mg kg-1 body weight of endosulfan was daily administered orally to one group of rats while another group was exposed to ungraded concentration of endosulfan by nose and whole body inhalation exposure method, (4 h daily, 6 days per week), for 30 days. It was observed from the results of this study that exposure to endosulfan by both oral and inhalation routes produced a significant increase (p<0.05) in serum creatinine, urea, BUN, uric acid and K+ and a significant decrease (p<0.05) in serum Na+ and Cl¯ levels, compared, respectively to the control. Also, microscopic examinations showed that both routes of exposure to endosulfan exhibited severe a histopathological damage to the renal tissues. These observations indicated that exposure to endosulfan may be a risk factor for nephrotoxicity in rats, independent of the route of exposure.
  M.U. Eteng , B.J. Bassey , I.J. Atangwho , G.E. Egbung , E.U. Eyong , P.E. Ebong and A.O. Abolaji
  Hypoglycemic and biochemical effects of herbal extracts of Vernonia amygdalina Del. (Compositae), Catharantus roseus (L.) G. Don (Apocynaceace) and chlorpropamide were compared and status of macrovascular complications evaluated using biochemical indices in normal and diabetic rats. The phytochemistry of the herbs was also assessed. Hypoglycemic activity of the herbs and chlorpropamide was evaluated on diabetic and non-diabetic rats but biochemical effects of the treatments was evaluated only on diabetic rats, assigned into four study groups (n = 8). Group I (control) received placebo (30% ethanol), treatment group II was gavaged with chlorpropamide in dose 14.28 mg kg-1 body weight, while groups III and IV were administered extracts of V. amygdalina (400 mg kg-1 body weight) and C. roseus (400 mg kg-1 body weight), respectively in 30% ethanol vehicle for 21 days. Results of the phytochemistry assessment identified alkaloids, cardiac glycosides, saponins, flavonoids, tannins in V. amygdalina and C. roseus. Triterpenes were identified only in V. amygdalina and anthroquinones only in C. roseus. All three treatments produced hypoglycaemic activity in normal and diabetic rats and significantly (p<0.05 to <0.01) reduced triglyceride and total Cholesterol relative to controls. C. roseus alone significantly (p<0.01) elevated HDL-Cholesterol. Serum protein significantly (p<0.05) increased in all treatments compared with controls. Urea levels decreased in all the treatments but more dramatic with chlorpropamide. Aminotransferase activity was not altered except serum ALT which was reduced in treated rats. Electrolyte profile showed dilutional hyponatremia with chlorpropamide treatment, which was absent in C. roseus treatment but mild in V. amygdalina. These changes in biochemical indices of toxicity and macrovascular complications are discussed with respect to the comparative therapeutic benefits of the three treatments.
  I.J. Atangwho , P.E. Ebong , M.U. Eteng , E.U. Eyong and A.U. Obi
  This research assessed the hypoglycemic action of ethanolic extract of Vernonia amygdalina del and its impact on selected indices of kidney function in experimental diabetic rat models. Twenty-one Wistar rats (120-160 g) assigned to 3 groups of seven rats each were used. Groups 1 and 3, constituting the diabetic (DC) and normal controls (NC), respectively were both given placebo treatment, whereas group 2 was the test group of animals administered the extract (400 mg kg-1 body weight) by gastric-intubation for 14 days. Results of analyses of serum electrolytes and biochemical indices showed: significant reductions (p<0.05) in glucose, urea and sodium concentrations of the V. amygdalina ethanolic extract treated group (144.14±25.83, 81.60±16.52 and 65.00±6.24, respectively) relative to their respective controls (247.25±4.83, 122.08±10.60 and 116.62±12.00). Serum chloride levels of the test group also reduced, whereas, that of potassium and creatinine were elevated with respect to their normal control values. However, these later changes were non-significant (p>0.05). Histological changes in the kidney tissues such as necrosis of tubules, degeneration of cells of glomerular capsule and partial obliteration of glomerular tuft observed in diabetic animals were reversed in extract treated diabetic group. Vernonia amygdalina extract besides its hypoglycemic action, can protect against kidney impairments due to diabetes, but may induce dilutional hyponatraemia.
  M.A. Agiang , I.B. Umoh , A.I. Essien and M.U. Eteng
  Evaluations of the effect of prolong cooking on the nutrient and antinutrient composition of beniseed and beniseed soup were carried out in this study. Proximate, mineral, vitamin A and C and antinutrient compositions of raw beniseed (BS-R), beniseed boiled (BSB) for 15, 30, 45 and 60 min and beniseed soup (BSS) cooked for the same intervals of time were assessed. Results of the proximate composition analyses showed that raw and boiled beniseed had lower moisture content (5.39-5.51%) than beniseed soups (10.06-15.20%). Nitrogen-free extract (total carbohydrates), fats and phosphorus contents were improved in both the boiled beniseed and beniseed soup while calcium and potassium were increased in the boiled seeds and soup samples respectively. Moisture (in the raw and boiled beniseed), ash, magnesium, zinc, iron contents in both the seed and soup were unchanged in all the samples. Vitamins A and C levels of both boiled beniseed and beniseed soup samples were reduced with increase in cooking time. Beniseed soup had higher protein contents than both the raw and boiled beniseed which decreased with increase in cooking time. Beniseed samples provided good sources of energy (572.97-666.05 kcal/100 g). Except for phytate, the levels of antinutrients tested were lower in the raw and boiled beniseed than in the soup samples which decreased with increase in cooking time. The results are discussed with reference to the effect of prolonged cooking on the nutrient requirements of consumers.
 
 
 
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