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Articles by M.T.J.A. Catanho
Total Records ( 3 ) for M.T.J.A. Catanho
  M.L. Gomes , E.A.C. Lima , S.M.S. Souza , L.C. Bernardo , M.E. Penas , R.L. Jales , M.T.J.A. Catanho and M. Bernardo Filho
  Natural or synthetic drugs can alter the bioavailability of radiopharmaceuticals used in diagnostic imaging in nuclear medicine. The knowledge of such altered bioavailability is important in making diagnostic of diseases and to try to understand biological effect of drugs in specific organs. The use of natural products has been increasing in the world. Echinacea is a natural product widely used for the treatment of respiratory tract infections. The aim of this study was to evaluate the effect of the echinacea on the bioavailability of the radiopharmaceutical 99mTc-sodium pertechnetate (Na99mTcO4) and on the mass of organs to try to verify possible undesirable actions of the studied natural product. An extract of Echinacea was daily administered by intragastric via into Wistar rats during 10 days. Na99mTcO4 (3.7MBq) was administered by ocular plexus via and 10 minutes after the animals were sacrificed. Blood and various organs were removed, their mass determined, their radioactivity counted in a well counter and the percentages of the injected dose per gram of organ (%ID/g) calculated. The results showed that in the treated animals: (i) the mass of the organs was not modified; (ii) the %ID/g decreased in lungs. The effect of echinacea on the Na99mTcO4 bioavailability in the lung was statistically significant (Student test, p<0.05) and it could be explained by the metabolization or therapeutic action of this herb in this organ.
  Souza, GM.L. , E.B. Carvalho and M.T.J.A. Catanho
  Medicinal plants originate natural products that are biologically active and widely employed as an alternative source in health care. Mulher ativa? is a compound which exhibits estrogen properties in the reproductive tract. Hence, the purposes of this work were to determine the antioxidant properties of natural supplement Mulher ativa? on the labeling of blood cells and plasmatic protein with Tc in vitro. Incubating 99m heparin with blood carried out the experiments. Different concentrations of Mulher ativa? were chosen as (200, 100, 50, 25, 12.5 mg mLG ). A stannous chloride solution was also added and incubation was kept for 60 min. After this, Tc was added and the incubation was continued for 10 min. The mixture was centrifuged, 99m precipitated with thichloroacetic acid 5% and soluble (SF) and insoluble fractions (IF) were separated. The radioactivities in P, BC, IF-P, SF-P, IF- BC, SF-BC were determined in a well counter The analysis of radioactivity in the samples of P and BC isolated from samples of whole blood treated with Mulher ativa?, showed decrease significant (p<0.05) uptake of the radioactivity by blood cells in presence of Mulher ativa?, whereas there was increase in the amount of Tc in the TCA-insoluble fraction of plasma. It is also concluded that presents 99m antioxidant properties.
  G.F. Dire , E.A.C. Lima , M.L. Gomes , S. Moreno , M.V.C. Faria , R.L. Jales , M.T.J.A. Catanho and M. Bernardo Filho
  Natural products have been widely used by human beings. However, sometimes the biological effects of these products are not fully known. It is concerned that many natural medicines may contain potentially toxic ingredients and contaminants such as heavy metals. Red blood cells (RBC) and plasma proteins labeled with technetium-99m (99mTc) have several clinical applications and it has been reported that some natural products are capable of reducing the efficiency of this radio labeling. The aim of this work was to assess the oxidant or antioxidant action of the agents presents in the extract of Sechium edule verifying its effects on the labeling of blood elements with 99mTc and on the inhibition of the activity of acetyl cholinesterase (AchE). A freshly extract of Sechium edule was administered to Wistar rats during 15 and 60 days. After that, samples (0.5ml) of blood were incubated with stannous chloride (SnCl2) and 99mTc. The blood was centrifuged and plasma (P) and RBC were isolated. P and RBC were also precipitated with trichloroacetic acid and soluble (S) and insoluble (I) fraction (F) were determined. The results have shown that the referred extract was able to reduce the radio labeling in BC to 15 days of treatment (from 98.77%± 0.45 to 90.35%± 5.04) to 60 days of treatment (from 98.77%± 0.45 to 53.53%± 0.91), in IF-BC (from 90.36%± 2.34 to 21.20%± 2.36) and in IF-P to 15 days of treatment (77.20%± 2.19 to 53.26%± 6.69) to 60 days of treatment (77.20%± 2.19 to 11.01%±3.22). The analysis of toxicology was performed by the determination of acetyl cholinesterase activity. In the light of the results the referred extract has not shown inhibitory action due to the activity of the enzyme. In the light of the results obtained we suggest that the referred extract may induce the generation of activity metabolites with oxidant properties with direct action on the labeling process.
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