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Articles by M.T. Yakubu
Total Records ( 2 ) for M.T. Yakubu
  O.O. Odeyemi , M.T. Yakubu , P.J. Masika and A.J. Afolayan
  The effects of the essential oil from Tagetes minuta leaves at 125, 250, 375 and 500 μL kg-1 b.wt. on some biochemical parameters of Wistar rats were studied. There was no significant difference in packed cell volume, mean corpuscular hemoglobin concentration, monocytes, lymphocytes, eosinophils, basophils, serum alanine transaminase, liver and kidney body weight ratios. However, the 125 μL kg-1 b.wt. resulted in significant decrease in red blood cell and hemoglobin, whereas the same dose produced increase in mean corpuscular volume, mean corpuscular hemoglobin, neutrophils and large unstained cell. Sodium, inorganic phosphorus, conjugated bilirubin, albumin, globulin and total protein at all the doses were not affected while potassium, chloride, urea, creatinine and total bilirubin concentration were increased at certain doses. Whereas the activity of serum gamma glutamyl transferase was significantly increased at all the doses, those of serum aspartate transaminase were increased only at 125 and 500 μL kg-1 b.wt. The kidney-body weight ratio was increased only at 375 and 500 μL kg-1 b.wt. The result showed that the oil of T. minuta had a mild effect on the parameters investigated at certain doses. This dose and parameter specific effects may influence the use of the essential oil from T. minuta as an insecticide against Sitophilus zeamais in maize grains meant for human and animal consumption.
  M.A. Akanji , M.T. Yakubu and M.I. Kazeem
  The aim of this study was to investigate the hypolipidemic potential of aqueous extract of Rauvolfia vomitoria root and assess its toxicological effect in selected tissues of rats. Aqueous extract of Rauvolfia vomitoria root was administered to wistar rats daily at 24 h interval at a dosage of 200 mg kg-1 b.wt. following which the rats were sacrificed after receiving 1, 3, 5, 10, 20 and 30 daily oral doses. Administration of the extract produced significant reduction (p<0.05) in the concentration of the Low-density Lipoprotein Cholesterol (LDL-C), triglyceride and atherogenic indices while a dose-dependent significant increase (p<0.05) occurred in the High-density Lipoprotein Cholesterol (HDL-C) concentration. Significant changes were also observed (p<0.05) in the activities of alkaline phosphatase (ALP) and acid phosphatase (ACP) in all the tissues studied except small intestine. There were significant fluctuations (p<0.05) in the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the tissues except in the kidney. The results suggest that aqueous extract of Rauvolfia vomitoria root possesses hypolipidemic potential but caused alterations in the concentration of the enzymes studied and so may not be completely safe at the dose used in this study.
 
 
 
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