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Articles by M.S. Auwal
Total Records ( 2 ) for M.S. Auwal
  M.S. Auwal , K.A. Sanda , I.A. Mairiga , F.A. Lawan , A.A. Mutah , A.N. Tijjani , A. Shuaibu , A. Ibrahim , A.B. Njobdi and A.B. Thaluvwa
  The phytochemical, elemental and hematologic effect of the crude mesocarp extract of Hyphaene thebaica (doumpalm) in wistar albino rats to ascertain the claims by herbalists and traditionalists in the management of anemia was evaluated. The Phytochemistry revealed the presence of tannins, saponins, steroids, carbohydrates, cardiac glycosides, flavonoids, terpenes and terpinoids in low and moderate concentrations. Alkaloids, phlobatannins and anthraquinones were absent. The elemental analysis of the extract revealed the presence of calcium, magnesium, potassium, iron and sodium in moderate concentration when compared to WHO concentration in ppm. The amount of manganese, zinc and silicon is low, whereas the amount of nickel, cobalt, molybdenum, arsenic and lead is negligible. There is significant (p<0.05) increase in red blood and white blood cells production at 1-4 weeks of extract administration, while parked cell volume and hemoglobin concentration increased at the second and third week of oral administration of 400, 600 and 800 mg kg-1 for four weeks of the extract respectively. This research have therefore supported the folkloric claims by traditionalists and herbalists in application of the crude mesocarp extract of Hyphaene thebaica (doumpalm) in the management of anemia in Askira/Uba, Maiduguri and other Local Government areas in Borno State, Nigeria.
  K.A. Sanda , U.K. Sandabe , M.S. Auwal , I. Bulama , T.M. Bashir , F.A. Sanda and I.A. Mairiga
  This study was designed to evaluate the antidiabetic profile and the hypoglycaemic activity of aqueous root extracts of L. hastata in normal and alloxan-induced diabetic rats model. Eighty five albino rats were used for this study out of this thirty five were used subjected to experimental diabetes by the use of alloxan at a dose of 160 mg kg-1 body weight. Seven experimental groups of five rats per group (A-G) were used for this study. A standard antidiabetic drug (insulin) group (B) and normal saline group (G) serves as positive control. The blood glucose lowering activity of the extract, insulin and normal saline groups were monitored at 0, 1, 3, 6, 12 and 18 h post extract administration. On the other hand the remaining fifty albino rats were used to determine the acute toxicity and the hypoglycemic activity of the extract. The blood glucose levels of the rats were monitored at 0, 7, 14, 21 and 28 days post extract administration. Oral administration of aqueous root extract at 600 and 800 mg kg-1 b.wt have significantly (p<0.05) decreased the blood glucose in diabetic albino rats. On the other hand the hypoglycemic activity of the aqueous root extract on normal rats at dose of 1000 mg kg-1 b.wt have significantly (p<0.05) decreases blood glucose level in normal albino rats. The results of the current study have demonstrated the antidiabetic and hypoglycaemic effects of L. hastata aqueous root extracts and underscore its potentials in the management of diabetes mellitus especially following prolonged use in days.
 
 
 
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