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Articles by M.S. Ashawat
Total Records ( 3 ) for M.S. Ashawat
  M.S. Ashawat , Gupta Amit , Saraf Shailendra and Saraf Swarnlata
  Because of increased leisure time, the growing popularity of staying outdoors, it has become more and more imperative to study the molecular photobiological effects due to ultraviolet (UV) radiation on human skin. Information obtained from several studies is being used to constantly improve the quality of sunscreen preparations containing organic and inorganic filters. It also fostering the development of antioxidants and active agents that can be used in combination with or in addition to UV filters to provide better photoprotection for human skin. In this review, the examples are specified to illustrate the role and mechanism of highly specific and complex molecules obtained from natural sources; recognized as enzymes and examples are given to the development in skin care products: the use of topically applied DNA repair enzymes to prevent UVB radiation induced damage and the protective mechanism of superoxide dismutase and peroxidase to reduce UV-induced erythema, which can also be thought of as free radical scavenging ability.
  Gupta Amit , M.S. Ashawat , Saraf Shailendra and Saraf Swarnlata
  Phytosomes are newly introduced structure, which contains the bioactive phytoconstituents of herb surrounds and bound by a lipid. Most of the bioactive constituents of phytomedicines are water-soluble compounds e.g., flavonoids, glycosides etc. Flavonoids are a major class of bioactive compounds possesses broad therapeutic activities. Most of the plant flavonoids i.e., glycyrrhizic acid, silymarin also having cosmetic value apart from their medicinal value, when applied topically. Plant flavonoids have local action on some diseases like inflammation, oedema, pain, fungal infections etc. But their use in topical application is restricted due to poor absorption through skin. Phytosomes are probably a system which can improve absorption of phytoconstituents through skin, to regulate the physiology of skin compositions. The improvement in the functioning of skin suggests the functional cosmetic value of the phytosomes. Generally the passage of the compounds anchored to phospholipids takes place through interaction with cutaneous structure, which influences the release of the phytoconstituents. The rate of absorption from the complex is dramatically enhanced with out damaging the epidermis, which suggesting potential use of phytoconstituent- phospholipids complex for cosmetic value in skin as well as for systemic function via skin.
  M.S. Ashawat , Saraf Shailendra and Saraf Swarnlata
  The present study was to prepare and characterized herbal cosmetic cream comprising extracts of G. glabra, C. longa (roots), seeds of P. corlifolia, C. tora, A. catechu, P. granatum, fruits of E. officinale, leaves of C. asiatica, dried bark of C. zeylanicum and fresh gel of A. vera for the protection of skin against UV induced aging. To investigate the antioxidant activity of cream formulations the UV radiation induced oxidative stress was generated in rats and protective effects were measured after topically applied (2 mg cm-2 day-1) for thirty days. The level of antioxidant enzymes (catalase and superoxidedismutase), non-enzyme components (ascorbic acid level and melanodialdehyde) and ascorbic acid were estimated. The structural changes were observed by using histological techniques. Results showed significant improvement in superoxidedismutase, catalase, total protein and ascorbic acid level with decreased melanodialdehyde level. The treatment with such herbal extracts containing creams could be utilized for the protection of photo induced intrinsic oxidative stress as well as structural alterations in skin.
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